Results 21 to 30 of about 35,307 (294)

Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities

Scientific Reports, 2020
When a muscle is stretched during a contraction, the resulting steady-state force is higher than the isometric force produced at a comparable sarcomere length.
Ricarda M. Haeger, Dilson E. Rassier
doaj   +1 more source

Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2

Cell Reports, 2021
Summary: Actinins are strain-sensing actin cross-linkers that are ubiquitously expressed and harbor mutations in human diseases. We utilize CRISPR, pluripotent stem cells, and BioID to study actinin interactomes in human cardiomyocytes.
Feria A. Ladha, Ketan Thakar, Anthony M. Pettinato, Nicholas Legere, Shahnaz Ghahremani, Rachel Cohn, Robert Romano, Emily Meredith, Yu-Sheng Chen, J. Travis Hinson   +9 more
doaj   +1 more source

Myomesin is part of an integrity pathway that responds to sarcomere damage and disease.

PLoS ONE, 2019
The structure and function of the sarcomere of striated muscle is well studied but the steps of sarcomere assembly and maintenance remain under-characterized.
Kendal Prill, Casey Carlisle, Megan Stannard, Pamela J Windsor Reid, David B Pilgrim   +4 more
doaj   +1 more source

Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

eLife, 2023
Palladin (PALLD) belongs to the PALLD/myopalladin (MYPN)/myotilin family of actin-associated immunoglobulin-containing proteins in the sarcomeric Z-line.
Giuseppina Mastrototaro, Pierluigi Carullo, Jianlin Zhang, Beatrice Scellini, Nicoletta Piroddi, Simona Nemska, Maria Carmela Filomena, Simone Serio, Carol A Otey, Chiara Tesi, Fabian Emrich, Wolfgang A Linke, Corrado Poggesi, Simona Boncompagni, Marie-Louise Bang   +14 more
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Half-sarcomere model.

, 2021
The half-sarcomere model describes the total force Fm produced by an active contractile element of length L (A). The crossbridges kinetic cycle is described with a 5-state model (B). The states highlighted in red correspond to attached crossbridges.
Sarah Kosta (417791), Pierre C. Dauby (11547497)   +1 more
core   +1 more source

Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes

eLife, 2018
The sarcomere is the contractile unit within cardiomyocytes driving heart muscle contraction. We sought to test the mechanisms regulating actin and myosin filament assembly during sarcomere formation.
Aidan M Fenix, Abigail C Neininger, Nilay Taneja, Karren Hyde, Mike R Visetsouk, Ryan J Garde, Baohong Liu, Benjamin R Nixon, Annabelle E Manalo, Jason R Becker, Scott W Crawley, David M Bader, Matthew J Tyska, Qi Liu, Jennifer H Gutzman, Dylan T Burnette   +15 more
doaj   +1 more source

Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

Cell Reports, 2021
Summary: Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using ...
Anthony M. Pettinato, Dasom Yoo, Jennifer VanOudenhove, Yu-Sheng Chen, Rachel Cohn, Feria A. Ladha, Xiulan Yang, Ketan Thakar, Robert Romano, Nicolas Legere, Emily Meredith, Paul Robson, Michael Regnier, Justin L. Cotney, Charles E. Murry, J. Travis Hinson   +15 more
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Overexpression of Lifeact-GFP Disrupts F-Actin Organization in Cardiomyocytes and Impairs Cardiac Function

Frontiers in Cell and Developmental Biology, 2021
Lifeact-GFP is a frequently used molecular probe to study F-actin structure and dynamic assembly in living cells. In this study, we generated transgenic zebrafish models expressing Lifeact-GFP specifically in cardiac muscles to investigate the effect of ...
Rui Xu, Shaojun Du
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Study of the Warner-Bratzler Shear Force, Sensory Analysis and Sarcomere Length as Indicators of the Tenderness of Sun-Dried Beef

Molecules, 2013
Sun-dried beef is a frequently consumed and valued product in Brazil, however, there have been no scientific studies on its texture. To assess the tenderness of sun-dried beef, an instrumental analysis (Warner-Bratzler Shear Force; WBSF), a sensory ...
Marta Madruga, Geany de Souza, Ricardo Moreira, Yuri Ishihara, Alanne Salviano   +4 more
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Mutations in PDLIM5 are rare in dilated cardiomyopathy but are emerging as potential disease modifiers

Molecular Genetics & Genomic Medicine, 2020
Background A causal genetic mutation is found in 40% of families with dilated cardiomyopathy (DCM), leaving a large percentage of families genetically unsolved. This prevents adequate counseling and clear recommendations in these families.
Job A. J. Verdonschot, Emma L. Robinson, Kiely N. James, Mohamed W. Mohamed, Godelieve R. F. Claes, Kari Casas, Els K. Vanhoutte, Mark R. Hazebroek, Gabriel Kringlen, Michele M. Pasierb, Arthur van denWijngaard, Jan F. C. Glatz, Stephane R. B. Heymans, Ingrid P. C. Krapels, Shareef Nahas, Han G. Brunner, Radek Szklarczyk   +16 more
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