Results 21 to 30 of about 51,464 (286)

Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia

Cell Reports, 2019
Summary: Precise assembly of the sarcomere, a force-generating unit in striated muscles, is critical for muscle contraction. Defective sarcomere organization is linked to myopathies and cachexia. The molecular mechanisms concerning sarcomere assembly are
Arnab Nayak, Alfredo J. Lopez-Davila, Ekaterini Kefalakes, Tim Holler, Theresia Kraft, Mamta Amrute-Nayak   +5 more
doaj   +1 more source

Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

eLife, 2023
Palladin (PALLD) belongs to the PALLD/myopalladin (MYPN)/myotilin family of actin-associated immunoglobulin-containing proteins in the sarcomeric Z-line.
Giuseppina Mastrototaro, Pierluigi Carullo, Jianlin Zhang, Beatrice Scellini, Nicoletta Piroddi, Simona Nemska, Maria Carmela Filomena, Simone Serio, Carol A Otey, Chiara Tesi, Fabian Emrich, Wolfgang A Linke, Corrado Poggesi, Simona Boncompagni, Marie-Louise Bang   +14 more
doaj   +1 more source

Myomesin is part of an integrity pathway that responds to sarcomere damage and disease.

PLoS ONE, 2019
The structure and function of the sarcomere of striated muscle is well studied but the steps of sarcomere assembly and maintenance remain under-characterized.
Kendal Prill, Casey Carlisle, Megan Stannard, Pamela J Windsor Reid, David B Pilgrim   +4 more
doaj   +1 more source

Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes

eLife, 2018
The sarcomere is the contractile unit within cardiomyocytes driving heart muscle contraction. We sought to test the mechanisms regulating actin and myosin filament assembly during sarcomere formation.
Aidan M Fenix, Abigail C Neininger, Nilay Taneja, Karren Hyde, Mike R Visetsouk, Ryan J Garde, Baohong Liu, Benjamin R Nixon, Annabelle E Manalo, Jason R Becker, Scott W Crawley, David M Bader, Matthew J Tyska, Qi Liu, Jennifer H Gutzman, Dylan T Burnette   +15 more
doaj   +1 more source

Fluid flow in the sarcomere [PDF]

Archives of Biochemistry and Biophysics, 2021
A highly organized and densely packed lattice of molecular machinery within the sarcomeres of muscle cells powers contraction. Although many of the proteins that drive contraction have been studied extensively, the mechanical impact of fluid shearing within the lattice of molecular machinery has received minimal attention. It was recently proposed that
Sage A. Malingen, Kaitlyn Hood, Eric Lauga, Anette Hosoi, Thomas L. Daniel   +4 more
openaire   +3 more sources

Compensated right ventricular function of the onset of pulmonary hypertension in a rat model depends on chamber remodeling and contractile augmentation. [PDF]

, 2018
Right-ventricular function is a good indicator of pulmonary arterial hypertension (PAH) prognosis; however, how the right ventricle (RV) adapts to the pressure overload is not well understood.
Abe K, Alencar A, Arts T, Bellofiore A, Benoist D, Benoist D, Blaudszun G, Cheng DC, Correia-Pinto J, de Man FS, Ewalenko P, Gomez-Arroyo JG, Guccione JM, Handoko ML, Handoko ML, Hardy MEL, Hessel MHM, Hoeper MM, Langer SFJ, Lee LC, Pacher P, Provencher S, Rain S, Schermuly RT, Shintani H, ter Keurs HE, Trip P, Umar S, Vaillancourt M, Vanderpool RR, Vinnakota KC, Wang Z, Werchan PM, White RJ, Yin X, Zhang X   +35 more
core   +1 more source

Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers [PDF]

, 2015
Aims: Nebulette is a 109 kDa modular protein localized in the sarcomeric Z-line of the heart. In vitro studies have suggested a role of nebulette in stabilizing the thin filament, and missense mutations in the nebulette gene were recently shown to be ...
Bang, Marie-Louise, Carullo, Pierluigi, Chen, Ju, Dalton, Nancy D., Gu, Yusu, Li, Xiaodong, Liang, Xingqun, Mastrototaro, Giuseppina, Peterson, Kirk L., Piroddi, Nicoletta, Poggesi, Corrado, Sheikh, Farah, Tesi, Chiara   +12 more
core   +2 more sources

Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

Cell Reports, 2021
Summary: Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using ...
Anthony M. Pettinato, Dasom Yoo, Jennifer VanOudenhove, Yu-Sheng Chen, Rachel Cohn, Feria A. Ladha, Xiulan Yang, Ketan Thakar, Robert Romano, Nicolas Legere, Emily Meredith, Paul Robson, Michael Regnier, Justin L. Cotney, Charles E. Murry, J. Travis Hinson   +15 more
doaj   +1 more source

Distorting the sarcomere [PDF]

Journal of General Physiology, 2010
One of the goals of cardiovascular science is to create a mathematical model of the heart that can predict ventricular function in healthy and diseased states, and that can be used to help improve treatment options for patients with heart disease. To be clinically useful, the model will have to include structural information about the shapes of the ...
openaire   +2 more sources

Overexpression of Lifeact-GFP Disrupts F-Actin Organization in Cardiomyocytes and Impairs Cardiac Function

Frontiers in Cell and Developmental Biology, 2021
Lifeact-GFP is a frequently used molecular probe to study F-actin structure and dynamic assembly in living cells. In this study, we generated transgenic zebrafish models expressing Lifeact-GFP specifically in cardiac muscles to investigate the effect of ...
Rui Xu, Shaojun Du
doaj   +1 more source