Results 21 to 30 of about 50 (46)
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The Sarcomere and Sarcomerogenesis
2008Striated muscle owes its name to the microscopic appearance, caused by the longitudinal alignment of thousands of highly ordered contractile units, the sarcomeres. The assembly (and disassembly) of these multiprotein complexes (sarcomere assembly or sarcomerogenesis) follows ordered pathways, which are regulated on the transcriptional, translational ...
Ehler, E, Gautel, M
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On the isometric equation of the sarcomere
Basic Research in Cardiology, 1974A model of the sarcomere is described, which is based upon (a) the sliding filament theory ofHuxley, (b) the ultrastructure of the sarcomere, (c) the biochemical mechanisms responsible for mechanical coupling and uncoupling of myosin and actin, (d) the constancy of the volume of the sarcomere and (e) a statistical analysis of random forces acting on ...
P J, Lewi, W K, Schaper, L M, Gijpen
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The Cardiac Sarcomere and Cell Cycle
Current Cardiology Reports, 2022The lack of adult human cardiomyocyte proliferative capacity impairs cardiac regeneration such as after myocardial injury. The sarcomere, a specialized actin cytoskeletal structure that is essential for twitch contraction in cardiomyocytes, has been considered a critical factor limiting adult human cardiomyocyte proliferation through incompletely ...
Anthony M. Pettinato +2 more
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Dysfunctional sarcomeric relaxation in the heart
Current Opinion in Physiology, 2022Since cardiac relaxation is commonly impaired in heart failure caused by many different etiologies, identifying druggable targets is a common goal. While many factors contribute to cardiac relaxation, this review focuses on sarcomeric relaxation and dysfunction.
Walter E, Knight, Kathleen C, Woulfe
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Targeting the sarcomere in inherited cardiomyopathies
Nature Reviews Cardiology, 2022Variants in >12 genes encoding sarcomeric proteins can cause various cardiomyopathies. The two most common are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Current therapeutics do not target the root causes of these diseases, but attempt to prevent disease progression and/or to manage symptoms.
Sarah J. Lehman +2 more
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Atomistic Simulations of Sarcomere Proteins
2023Concerted atomic motions are requisite for sarcomere protein function and may become disrupted in HCM pathologies. Computational approaches such as molecular dynamics simulation can resolve such dynamics with unrivalled spatial and temporal resolution.
Matthew Carter, Childers +1 more
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Force produced by isolated sarcomeres and half-sarcomeres after an imposed stretch
American Journal of Physiology-Cell Physiology, 2012When a stretch is imposed to activated muscles, there is a residual force enhancement that persists after the stretch; the force is higher than that produced during an isometric contraction in the corresponding length. The mechanisms behind the force enhancement remain elusive, and there is disagreement if it represents a sarcomeric property, or if it
Dilson E, Rassier, Ivan, Pavlov
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Myofilaments: Movers and Rulers of the Sarcomere
Comprehensive Physiology, 2017ABSTRACT Striated cardiac and skeletal muscles play very different roles in the body, but they are similar at the molecular level. In particular, contraction, regardless of the type of muscle, is a precise and complex process involving the integral protein myofilaments and their associated regulatory components ...
Brian Leei, Lin +2 more
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2010
Skeletal muscle cells, more commonly called muscle fibres, are multinucleated syncytia formed during development by fusion of mononucleated precursor cells, the myoblasts. They measure 10–100 μm in diameter and can have lengths from a few millimeters up to almost a meter.
Margit Pavelka, Jürgen Roth
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Skeletal muscle cells, more commonly called muscle fibres, are multinucleated syncytia formed during development by fusion of mononucleated precursor cells, the myoblasts. They measure 10–100 μm in diameter and can have lengths from a few millimeters up to almost a meter.
Margit Pavelka, Jürgen Roth
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1989
Studies on the mechanics of sarcomeres at the level of single myofibrils or single myocytes revealed properties not predicted by the cross-bridge theory of muscle contraction. This paper summarizes four major aspects: 1. Passive compression of the sarcomere showed two inflections in the force length curve; one was at the length where opposing ...
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Studies on the mechanics of sarcomeres at the level of single myofibrils or single myocytes revealed properties not predicted by the cross-bridge theory of muscle contraction. This paper summarizes four major aspects: 1. Passive compression of the sarcomere showed two inflections in the force length curve; one was at the length where opposing ...
openaire +1 more source