Results 21 to 30 of about 29,455 (242)

Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes

eLife, 2018
The sarcomere is the contractile unit within cardiomyocytes driving heart muscle contraction. We sought to test the mechanisms regulating actin and myosin filament assembly during sarcomere formation.
Aidan M Fenix, Abigail C Neininger, Nilay Taneja, Karren Hyde, Mike R Visetsouk, Ryan J Garde, Baohong Liu, Benjamin R Nixon, Annabelle E Manalo, Jason R Becker, Scott W Crawley, David M Bader, Matthew J Tyska, Qi Liu, Jennifer H Gutzman, Dylan T Burnette   +15 more
doaj   +1 more source

Study of the Warner-Bratzler Shear Force, Sensory Analysis and Sarcomere Length as Indicators of the Tenderness of Sun-Dried Beef

Molecules, 2013
Sun-dried beef is a frequently consumed and valued product in Brazil, however, there have been no scientific studies on its texture. To assess the tenderness of sun-dried beef, an instrumental analysis (Warner-Bratzler Shear Force; WBSF), a sensory ...
Marta Madruga, Geany de Souza, Ricardo Moreira, Yuri Ishihara, Alanne Salviano   +4 more
doaj   +1 more source

Mutations in PDLIM5 are rare in dilated cardiomyopathy but are emerging as potential disease modifiers

Molecular Genetics & Genomic Medicine, 2020
Background A causal genetic mutation is found in 40% of families with dilated cardiomyopathy (DCM), leaving a large percentage of families genetically unsolved. This prevents adequate counseling and clear recommendations in these families.
Job A. J. Verdonschot, Emma L. Robinson, Kiely N. James, Mohamed W. Mohamed, Godelieve R. F. Claes, Kari Casas, Els K. Vanhoutte, Mark R. Hazebroek, Gabriel Kringlen, Michele M. Pasierb, Arthur van denWijngaard, Jan F. C. Glatz, Stephane R. B. Heymans, Ingrid P. C. Krapels, Shareef Nahas, Han G. Brunner, Radek Szklarczyk   +16 more
doaj   +1 more source

Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

Cell Reports, 2021
Summary: Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using ...
Anthony M. Pettinato, Dasom Yoo, Jennifer VanOudenhove, Yu-Sheng Chen, Rachel Cohn, Feria A. Ladha, Xiulan Yang, Ketan Thakar, Robert Romano, Nicolas Legere, Emily Meredith, Paul Robson, Michael Regnier, Justin L. Cotney, Charles E. Murry, J. Travis Hinson   +15 more
doaj   +1 more source

Overexpression of Lifeact-GFP Disrupts F-Actin Organization in Cardiomyocytes and Impairs Cardiac Function

Frontiers in Cell and Developmental Biology, 2021
Lifeact-GFP is a frequently used molecular probe to study F-actin structure and dynamic assembly in living cells. In this study, we generated transgenic zebrafish models expressing Lifeact-GFP specifically in cardiac muscles to investigate the effect of ...
Rui Xu, Shaojun Du
doaj   +1 more source

An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish

eLife, 2015
Truncating mutations in the giant sarcomeric protein Titin result in dilated cardiomyopathy and skeletal myopathy. The most severely affected dilated cardiomyopathy patients harbor Titin truncations in the C-terminal two-thirds of the protein, suggesting
Jun Zou, Diana Tran, Mai Baalbaki, Ling Fung Tang, Annie Poon, Angelo Pelonero, Erron W Titus, Christiana Yuan, Chenxu Shi, Shruthi Patchava, Elizabeth Halper, Jasmine Garg, Irina Movsesyan, Chaoying Yin, Roland Wu, Lisa D Wilsbacher, Jiandong Liu, Ronald L Hager, Shaun R Coughlin, Martin Jinek, Clive R Pullinger, John P Kane, Daniel O Hart, Pui-Yan Kwok, Rahul C Deo   +24 more
doaj   +1 more source

Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review

Cells, 2020
The maintenance of skeletal muscle mass plays a critical role in health and quality of life. One of the most potent regulators of skeletal muscle mass is mechanical loading, and numerous studies have led to a reasonably clear understanding of the ...
Kent W. Jorgenson, Stuart M. Phillips, Troy A. Hornberger   +2 more
doaj   +1 more source

Disruption of a GATA4/Ankrd1 signaling axis in cardiomyocytes leads to sarcomere disarray: implications for anthracycline cardiomyopathy. [PDF]

PLoS ONE, 2012
Doxorubicin (Adriamycin) is an effective anti-cancer drug, but its clinical usage is limited by a dose-dependent cardiotoxicity characterized by widespread sarcomere disarray and loss of myofilaments.
Billy Chen, Lin Zhong, Sarah F Roush, Laura Pentassuglia, Xuyang Peng, Susan Samaras, Jeffrey M Davidson, Douglas B Sawyer, Chee Chew Lim   +8 more
doaj   +1 more source

Biomechanical Properties of Paraspinal Muscles Influence Spinal Loading—A Musculoskeletal Simulation Study

Frontiers in Bioengineering and Biotechnology, 2022
Paraspinal muscles are vital to the functioning of the spine. Changes in muscle physiological cross-sectional area significantly affect spinal loading, but the importance of other muscle biomechanical properties remains unclear.
Masoud Malakoutian, Masoud Malakoutian, C. Antonio Sanchez, Stephen H. M. Brown, John Street, John Street, Sidney Fels, Thomas R. Oxland, Thomas R. Oxland, Thomas R. Oxland   +9 more
doaj   +1 more source

Metformin Protects against Diabetic Cardiomyopathy: An Association between Desmin–Sarcomere Injury and the iNOS/mTOR/TIMP-1 Fibrosis Axis

Biomedicines, 2022
The intermediate filament protein desmin is essential for maintaining the structural integrity of sarcomeres, the fundamental unit of cardiac muscle. Diabetes mellitus (DM) can cause desmin to become dysregulated, following episodes of nitrosative stress,
Amal F. Dawood, Norah M. Alzamil, Peter W. Hewett, Maha A. Momenah, Mohammad Dallak, Samaa S. Kamar, Dina H. Abdel Kader, Hanaa Yassin, Mohamed A. Haidara, Amro Maarouf, Bahjat Al-Ani   +10 more
doaj   +1 more source