Results 71 to 80 of about 2,672 (202)
Journal of Food Science, Volume 90, Issue 10, October 2025.ABSTRACT Dry‐aged beef is valued for its tenderness, complex aroma, and concentrated flavor. However, variability in aging protocols and limited understanding of underlying biological and technological processes can compromise consistent quality and safety.
Ana J. Ribeiro +3 more
wiley +1 more source
Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle
, 2020 Regulating the thin-filament length in muscle is crucial for controlling the number of myosin motors that generate power. The giant protein nebulin forms a long slender filament that associates along the length of the thin filament in skeletal muscle ...
Gregorio, Carol +10 more
core +1 more source
Deciphering the Functional Properties of Nebulin: It is a Stabilizer! [PDF]
Biophysical Journal, 2011 Striated muscle cells display one of the most extreme examples of molecular organization found in nature. Efficient muscle contraction requires precise regulation of actin (thin) filament lengths. In one highly cited model, the giant protein nebulin (∼750-900 kDa) has been proposed to function as a “molecular ruler” specifying filament lengths.
Pappas, Chris T. +2 more
openaire +1 more source
Different Lower Limb Muscle MRI Patterns in Autosomal Dominant Titinopathies
European Journal of Neurology, Volume 32, Issue 10, October 2025.ABSTRACT Background and Purpose Titin is critical for sarcomere structure and function, and mutations in this gene cause titinopathies, a group of neuromuscular disorders. Muscle MRI is a key tool for diagnosing and understanding these conditions.
David Gómez‐Andrés +8 more
wiley +1 more source
Cytoskeleton, Volume 82, Issue 9, Page 571-591, September 2025.ABSTRACT Actin filaments are dynamic polymers whose length depends on regulated monomer association and dissociation at their ends. Actin barbed‐end dynamics are relatively better understood, primarily due to the approximately tenfold faster subunit on/off rates at barbed versus pointed ends.
Sawako Yamashiro +5 more
wiley +1 more source
A six-module human nebulin fragment bundles actin filaments and induces actin polymerization
, 1998 Gonsior SM, Gautel M, Hinssen H. A six-module human nebulin fragment bundles actin filaments and induces actin polymerization. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 1998;19(3):225-235.We have investigated the interaction of a 6-repeat recombinant
Gautel, M, Hinssen, Horst, Gonsior, SM
core +1 more source
New Insights into the Structural Roles of Nebulin in Skeletal Muscle [PDF]
, 2010 One important feature of muscle structure and function that has remained relatively obscure is the mechanism that regulates thin filament length. Filament length is an important aspect of muscle function as force production is proportional to the amount ...
Granzier, H. +3 more
core +1 more source
Nebulin doesn't measure up [PDF]
Journal of Cell Biology, 2010 ![Figure][1] Nebulin (red) stabilizes actin filaments (green) to protect them from latrunculin A. In the protein’s absence (right), the depolymerizing drug causes filament disassembly.
openaire +1 more source
Two alternatively-spliced human nebulin isoforms with either exon 143 or exon 144 and their developmental regulation [PDF]
, 2018 Nebulin is a very large protein required for assembly of the contractile machinery in muscle. Mutations in the nebulin gene NEB are a common cause of nemaline myopathy.
Le, Thanh Lam +7 more
core +3 more sources
Acta Neuropathologica Communications, 2020 Nemaline myopathy (NM) caused by mutations in the gene encoding nebulin (NEB) accounts for at least 50% of all NM cases worldwide, representing a significant disease burden.
Jenni M. Laitila +19 more
doaj +1 more source