Interaction of cardiac leiomodin with the native cardiac thin filament. [PDF]
PLoS BiologyEvery heartbeat depends on cyclical contraction-relaxation produced by the interactions between myosin-containing thick and actin-based thin filaments (TFs) arranged into a crystalline-like lattice in the cardiac sarcomere.
Madison Little +9 more
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Thin filament cardiomyopathies: A review of genetics, disease mechanisms, and emerging therapeutics [PDF]
Frontiers in Cardiovascular Medicine, 2022 All muscle contraction occurs due to the cyclical interaction between sarcomeric thin and thick filament proteins within the myocyte. The thin filament consists of the proteins actin, tropomyosin, Troponin C, Troponin I, and Troponin T.
Lucas K. Keyt +7 more
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The force of the myosin motor sets cooperativity in thin filament activation of skeletal muscles [PDF]
Communications Biology, 2022 Sarcomeres of Ca2 + -activated demembranated fibres of rabbit soleus muscles show that the stress exerted by each motor protein on the thin filament determines the cooperativity in thin filament activation.
Marco Caremani +9 more
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Natural history and clinical outcomes of patients with hypertrophic cardiomyopathy from thin filament mutations [PDF]
ESC Heart FailureHypertrophic cardiomyopathy (HCM) due to thick filament variants is more common; however, HCM due to thin filament variants (HCM‐Thin) may be associated with a more malignant phenotype with an increased risk of sudden cardiac death. The aim of this study
Tatiana Saul +5 more
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Mutation‐specific effects on thin filament length in thin filament myopathy [PDF]
Annals of Neurology, 2016 ObjectiveThin filament myopathies are among the most common nondystrophic congenital muscular disorders, and are caused by mutations in genes encoding proteins that are associated with the skeletal muscle thin filament. Mechanisms underlying muscle weakness are poorly understood, but might involve the length of the thin filament, an important ...
Winter, J.M. +22 more
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Modeling Human Cardiac Thin Filament Structures [PDF]
Frontiers in Physiology, 2022 Striated muscle contraction is regulated in a calcium-dependent manner through dynamic motions of the tropomyosin/troponin polymer, a multicomponent complex wrapped around actin-containing thin filaments.
Michael J. Rynkiewicz +2 more
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The mechanism of thin filament regulation: Models in conflict? [PDF]
J Gen Physiol, 2019 In a recent JGP article, Heeley et al. (2019. J. Gen. Physiol. https://doi.org/10.1085/jgp.201812198) reopened the debate about two- versus three-state models of thin filament regulation. The authors review their work, which measures the rate constant of Pi release from myosin.ADP.Pi activated by actin or thin filaments under a variety of conditions ...
Geeves MA, Lehrer SS, Lehman W.
europepmc +4 more sources
The Mechanisms of Thin Filament Assembly and Length Regulation in Muscles [PDF]
International Journal of Molecular Sciences, 2022 Szilárd Szikora +2 more
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Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy [PDF]
Journal of Molecular BiologyCristina M Risi +2 more
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Modeling Thin Filament Cooperativity [PDF]
Biophysical Journal, 2002 We were very interested in the paper by Chen et al. (2001) on the modeling of the kinetic and equilibrium binding of myosin S1 to regulated actin filaments, containing actin, tropomyosin, and troponin (ATmTn). This is a formidable task, and the authors of the paper are to be commended on their considerable achievement.
Geeves, M.A., Lehrer, S.S.
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