Results 1 to 10 of about 34,865 (227)

Tropomyosin-based cross-reactivity and asymptomatic shellfish sensitization in patients with perennial allergy [PDF]

Frontiers in Allergy
BackgroundMite, cockroach, and shellfish (crab, clam, and shrimp) proteins share allergenic epitopes. The determination of specific IgE (sIgE) against cockroach (Blattella germanica, relevant in asthma) and shellfish allergens (relevant in food allergy ...
Moritz Maximilian Hollstein, Marie Charlotte Schuppe, Katharina Klara Hahn, Prasad Dasari, Susann Forkel, Caroline Beutner, Timo Buhl, Timo Buhl   +7 more
doaj   +2 more sources

Role of Tpm Isoforms Produced by the TPM4 Gene in the Regulation of Actin Filament Dynamics by Cofilin [PDF]

Biomolecules
The actin cytoskeleton determines a huge number of intracellular processes, as well as maintaining the cell shape, transport, formation of intercellular contacts, etc.
Svetlana G. Roman, Victoria V. Nefedova, Alexander M. Matyushenko   +2 more
doaj   +2 more sources

Mutual dependence between tropomodulin and tropomyosin in the regulation of sarcomeric actin assembly in Caenorhabditis elegans striated muscle

European Journal of Cell Biology, 2022
Tropomodulin and tropomyosin are important components of sarcomeric thin filaments in striated muscles. Tropomyosin decorates the side of actin filaments and enhances tropomodulin capping at the pointed ends of the filaments.
Shoichiro Ono, Mario Lewis, Kanako Ono
doaj   +1 more source

Alternative splicing of a single exon causes a major impact on the affinity of Caenorhabditis elegans tropomyosin isoforms for actin filaments

Frontiers in Cell and Developmental Biology, 2023
Tropomyosin is generally known as an actin-binding protein that regulates actomyosin interaction and actin filament stability. In metazoans, multiple tropomyosin isoforms are expressed, and some of them are involved in generating subpopulations of actin ...
Shoichiro Ono, Shoichiro Ono, Eichi Watabe, Keita Morisaki, Kanako Ono, Kanako Ono, Hidehito Kuroyanagi, Hidehito Kuroyanagi   +7 more
doaj   +1 more source

Distinct actin–tropomyosin cofilament populations drive the functional diversification of cytoskeletal myosin motor complexes

iScience, 2022
Summary: The effects of N-terminal acetylation of the high molecular weight tropomyosin isoforms Tpm1.6 and Tpm2.1 and the low molecular weight isoforms Tpm1.12, Tpm3.1, and Tpm4.2 on the actin affinity and the thermal stability of actin-tropomyosin ...
Theresia Reindl, Sven Giese, Johannes N. Greve, Patrick Y. Reinke, Igor Chizhov, Sharissa L. Latham, Daniel P. Mulvihill, Manuel H. Taft, Dietmar J. Manstein   +8 more
doaj   +1 more source

Mutations changing tropomodulin affinity for tropomyosin alter neurite formation and extension [PDF]

PeerJ, 2013
Assembly of the actin cytoskeleton is an important part of formation of neurites in developing neurons. Tropomodulin, a tropomyosin-dependent capping protein for the pointed end of the actin filament, is one of the key players in this process ...
Natalia Moroz, Laurent Guillaud, Brinda Desai, Alla S. Kostyukova   +3 more
doaj   +2 more sources

Changing the IgE Binding Capacity of Tropomyosin in Shrimp through Structural Modification Induced by Cold Plasma and Glycation Treatment

Foods, 2023
Tropomyosin (TM) is the major allergen of shrimp (Penaeus chinensis). Previous studies showed that separate cold plasma or glycation have their drawback in reducing allergenicity of TM, including effectiveness and reliability. In the current study, a new
Feng-Qi Wang, Jun-Hu Cheng, Kevin M. Keener   +2 more
doaj   +1 more source

Co-Immunization Efficacy of Recombinant Antigens against Rhipicephalus microplus and Hyalomma anatolicumTick Infestations

Pathogens, 2023
The immunoprophylactic management of ticks is the most effective option to control tick infestations and counter spread the acaricide resistance problem worldwide.
Balasamudram Chandrasekhar Parthasarathi, Binod Kumar, S. K. Bhure, Anil Kumar Sharma, Manisha, Gaurav Nagar, Sachin Kumar, Abhijit Nandi, Haranahally Vasanthachar Manjunathachar, Gajanan M. Chigure, Mukesh Shakya, Muthu Sankar, José de la Fuente, Srikant Ghosh   +13 more
doaj   +1 more source

cGMP interacts with tropomyosin and downregulates actin-tropomyosin-myosin complex interaction

Respiratory Research, 2018
Background The nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway, plays a critical role in the pathogenesis of pulmonary arterial hypertension (PAH); however, its exact molecular mechanism remains ...
Lihui Zou, Junhua Zhang, Jingli Han, Wenqing Li, Fei Su, Xiaomao Xu, Zhenguo Zhai, Fei Xiao   +7 more
doaj   +1 more source

Tropomyosin diffusion over actin subunits facilitates thin filament assembly

Structural Dynamics, 2016
Coiled-coil tropomyosin binds to consecutive actin-subunits along actin-containing thin filaments. Tropomyosin molecules then polymerize head-to-tail to form cables that wrap helically around the filaments. Little is known about the assembly process that
Stefan Fischer, Michael J. Rynkiewicz, Jeffrey R. Moore, William Lehman   +3 more
doaj   +1 more source