Results 1 to 10 of about 2,101 (172)

Effects of Tropomodulin 2 on Dendritic Spine Reorganization and Dynamics [PDF]

Biomolecules, 2023
Dendritic spines are actin-rich protrusions that receive a signal from the axon at the synapse. Remodeling of cytoskeletal actin is tightly connected to dendritic spine morphology-mediated synaptic plasticity of the neuron.
Balaganesh Kuruba, Nickolas Starks, Mary Rose Josten, Ori Naveh, Gary Wayman, Marina Mikhaylova, Alla S. Kostyukova   +6 more
doaj   +8 more sources

Novel secreted STPKLRR from Vibrio splendidus AJ01 promotes pathogen internalization via mediating tropomodulin phosphorylation dependent cytoskeleton rearrangement. [PDF]

PLoS Pathogens, 2023
We previously demonstrated that the flagellin of intracellular Vibrio splendidus AJ01 could be specifically identified by tropomodulin (Tmod) and further mediate p53-dependent coelomocyte apoptosis in the sea cucumber Apostichopus japonicus.
Fa Dai, Ming Guo, Yina Shao, Chenghua Li
doaj   +3 more sources

Tropomodulin–Tropomyosin Interplay Modulates Interaction Between Cardiac Myosin and Thin Filaments [PDF]

Biomolecules
Tropomodulin (Tmod) is an actin-binding protein that interacts with tropomyosin and the actin filament at the pointed end. The influence of Tmod on the thin filament activation in the myocardium is not clear.
Galina V. Kopylova, Anastasia M. Kochurova, Evgeniia A. Beldiia, Andrey V. Slushchev, Victoria V. Nefedova, Natalia S. Ryabkova, Ivan A. Katrukha, Daria S. Yampolskaya, Alexander M. Matyushenko, Daniil V. Shchepkin   +9 more
doaj   +3 more sources

Nodding syndrome is unlikely to be an autoimmune reaction to leiomodin-1 after infection by Onchocerca volvulus [PDF]

Biochemistry and Biophysics Reports, 2023
Nodding syndrome is a neurological disease of children in northern Uganda. Infection with the nematode parasite Onchocerca volvulus has been epidemiologically implicated as the cause of the disease.
Kenneth G. Kodja, Sylvester Onzivua, David L. Kitara, Amanda Fong, Patrick Kim, Michael S. Pollanen   +5 more
doaj   +2 more sources

Mutual dependence between tropomodulin and tropomyosin in the regulation of sarcomeric actin assembly in Caenorhabditis elegans striated muscle [PDF]

European Journal of Cell Biology, 2022
Tropomodulin and tropomyosin are important components of sarcomeric thin filaments in striated muscles. Tropomyosin decorates the side of actin filaments and enhances tropomodulin capping at the pointed ends of the filaments.
Shoichiro Ono, Mario Lewis, Kanako Ono
doaj   +2 more sources

SH3BGRL proteins are thioredoxin fold–containing actin filament pointed end capping proteins (TPECs) [PDF]

Scientific Reports
Cellular actin dynamics are tightly regulated by actin-binding proteins with specialized domains. Here, we identify SH3BGRL proteins as modulators of actin dynamics, characterized by their thioredoxin (Trx) fold and the absence of the canonical enzymatic
Robin S. Heiringhoff, Daniel Marke, Ute Curth, Johannes N. Greve   +3 more
doaj   +2 more sources

An Integrated Structural Model of the Palladin-Actin Complex Using XL-MS, SAXS, NMR, and Docking Approaches [PDF]

Structural Dynamics
Palladin is an actin-binding protein that accelerates actin polymerization and is implicated in the metastasis of multiple cancer types. Although three key lysine residues in an immunoglobulin-like domain of palladin have been identified as essential for
Moriah R Beck, Rachel A Sargent, David H Liu, Rahul Yadav   +3 more
doaj   +2 more sources

Interaction of cardiac leiomodin with the native cardiac thin filament. [PDF]

PLoS Biology
Every heartbeat depends on cyclical contraction-relaxation produced by the interactions between myosin-containing thick and actin-based thin filaments (TFs) arranged into a crystalline-like lattice in the cardiac sarcomere.
Madison Little, Cristina M Risi, Tania M Larrinaga, Mason D Summers, Tyler Nguyen, Garry E Smith, Jennifer Atherton, Carol C Gregorio, Alla S Kostyukova, Vitold E Galkin   +9 more
doaj   +2 more sources

Interaction between CDC6 and Tmod3 accelerates resistance to paclitaxel through focal adhesion assembly [PDF]

Signal Transduction and Targeted Therapy
The widespread clinical application of paclitaxel (PTX) in cancer treatment has been significantly limited by the emergence of drug resistance and the presence of drug-tolerant persister cells. To systematically identify key regulators of this resistance,
Yue Liu, Huirui Wang, Jie Zhan, Jiabo Sun, Yan Sun, Xiaojie Fu, Dongxue Lv, Xiuyun Li, Ting Dong, Hongxiang Lou   +9 more
doaj   +2 more sources

M6A-modified BFSP1 induces aerobic glycolysis to promote liver cancer growth and metastasis through upregulating tropomodulin 4 [PDF]

Molecular Biomedicine
RNA N6-methyladenosine (m6A) is a common RNA modification in eukaryotes, and its abnormal regulation is closely related to cancer progression. Aerobic glycolysis is a main way for cancer cells to obtain energy.
Rong Li, Shunle Li, Lin Shen, Junhui Li, Di Zhang, Jinmin Yu, Lanxuan Huang, Na Liu, Hongwei Lu, Meng Xu   +9 more
doaj   +2 more sources