Effects of Tropomodulin 2 on Dendritic Spine Reorganization and Dynamics [PDF]
Biomolecules, 2023 Dendritic spines are actin-rich protrusions that receive a signal from the axon at the synapse. Remodeling of cytoskeletal actin is tightly connected to dendritic spine morphology-mediated synaptic plasticity of the neuron.
Marina Mikhaylova +2 more
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Nodding syndrome is unlikely to be an autoimmune reaction to leiomodin-1 after infection by Onchocerca volvulus [PDF]
Biochemistry and Biophysics Reports, 2023 Nodding syndrome is a neurological disease of children in northern Uganda. Infection with the nematode parasite Onchocerca volvulus has been epidemiologically implicated as the cause of the disease.
Kenneth G. Kodja +5 more
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Mutual dependence between tropomodulin and tropomyosin in the regulation of sarcomeric actin assembly in Caenorhabditis elegans striated muscle [PDF]
European Journal of Cell Biology, 2022 Tropomodulin and tropomyosin are important components of sarcomeric thin filaments in striated muscles. Tropomyosin decorates the side of actin filaments and enhances tropomodulin capping at the pointed ends of the filaments.
Shoichiro Ono, Mario Lewis, Kanako Ono
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Tropomodulin–Tropomyosin Interplay Modulates Interaction Between Cardiac Myosin and Thin Filaments [PDF]
BiomoleculesTropomodulin (Tmod) is an actin-binding protein that interacts with tropomyosin and the actin filament at the pointed end. The influence of Tmod on the thin filament activation in the myocardium is not clear.
Galina V. Kopylova +9 more
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Novel secreted STPKLRR from Vibrio splendidus AJ01 promotes pathogen internalization via mediating tropomodulin phosphorylation dependent cytoskeleton rearrangement. [PDF]
PLoS Pathogens, 2023 We previously demonstrated that the flagellin of intracellular Vibrio splendidus AJ01 could be specifically identified by tropomodulin (Tmod) and further mediate p53-dependent coelomocyte apoptosis in the sea cucumber Apostichopus japonicus.
Fa Dai, Ming Guo, Yina Shao, Chenghua Li
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SH3BGRL proteins are thioredoxin fold–containing actin filament pointed end capping proteins (TPECs) [PDF]
Scientific ReportsCellular actin dynamics are tightly regulated by actin-binding proteins with specialized domains. Here, we identify SH3BGRL proteins as modulators of actin dynamics, characterized by their thioredoxin (Trx) fold and the absence of the canonical enzymatic
Robin S. Heiringhoff +3 more
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Tropomodulin’s Actin-Binding Abilities Are Required to Modulate Dendrite Development
Frontiers in Molecular Neuroscience, 2018 There are many unanswered questions about the roles of the actin pointed end capping and actin nucleation by tropomodulins (Tmod) in regulating neural morphology.
Alla Kostyukova +2 more
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Mechanism of actin thin filament pointed-end elongation by leiomodin [PDF]
Nature CommunicationsIn non-muscle cells, actin filaments exhibit variable lengths and rapid turnover, with subunits adding primarily at the barbed end. The situation is strikingly different in striated muscle sarcomeres, where despite rapid turnover, actin thin filaments ...
Shayna B. Brotzman +3 more
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An Integrated Structural Model of the Palladin-Actin Complex Using XL-MS, SAXS, NMR, and Docking Approaches [PDF]
Structural DynamicsPalladin is an actin-binding protein that accelerates actin polymerization and is implicated in the metastasis of multiple cancer types. Although three key lysine residues in an immunoglobulin-like domain of palladin have been identified as essential for
Moriah R Beck +3 more
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Interaction of cardiac leiomodin with the native cardiac thin filament. [PDF]
PLoS BiologyEvery heartbeat depends on cyclical contraction-relaxation produced by the interactions between myosin-containing thick and actin-based thin filaments (TFs) arranged into a crystalline-like lattice in the cardiac sarcomere.
Madison Little +9 more
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