Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts [PDF]
Frontiers in Endocrinology, 2021 Insulin and muscle contractions mediate glucose transporter 4 (GLUT4) translocation and insertion into the plasma membrane (PM) for glucose uptake in skeletal muscles.
Man Mohan Shrestha +2 more
exaly +7 more sources
Interaction between CDC6 and Tmod3 accelerates resistance to paclitaxel through focal adhesion assembly [PDF]
Signal Transduction and Targeted TherapyThe widespread clinical application of paclitaxel (PTX) in cancer treatment has been significantly limited by the emergence of drug resistance and the presence of drug-tolerant persister cells. To systematically identify key regulators of this resistance,
Ting Dong, Hong-Xiang Lou, Dong Ting
exaly +6 more sources
YWHAG promotes bladder cancer metastasis by regulating TMOD3 to activate ERK1/2 and JNK phosphorylation in the MAPK pathway [PDF]
Journal of Translational MedicineObjective This study aims to investigate the molecular mechanisms by which YWHAG (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma) promotes metastasis in bladder cancer.
Tai Tian, Wenzhi Gao, Aixiang Wang
exaly +5 more sources
MicroRNA-145 Regulates Pathological Retinal Angiogenesis by Suppression of TMOD3 [PDF]
Molecular Therapy - Nucleic Acids, 2019 Pathological angiogenesis is a hallmark of various vascular diseases, including vascular eye disorders. Dysregulation of microRNAs (miRNAs), a group of small regulatory RNAs, has been implicated in the regulation of ocular neovascularization.
Chi-Hsiu Liu +2 more
exaly +5 more sources
MicroRNA‑490‑3p suppresses the proliferation and invasion of hepatocellular carcinoma cells via targeting TMOD3 [PDF]
Oncology Letters, 2020 Hepatocellular carcinoma (HCC) is a primary malignancy of the liver. It has been reported that microRNAs (miRs) play important roles in the progression and development of HCC. The expression of miR-490-3p has been shown to be downregulated in HCC tissues.
Honghua Wang
exaly +5 more sources
Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling [PDF]
Journal of Experimental & Clinical Cancer Research, 2022 Background Abnormal proliferation and migration of cells are hallmarks of cancer initiation and malignancy. Asparagine endopeptidase (AEP) has specific substrate cleavage ability and plays a pro-cancer role in a variety of cancers.
Binghong Chen +13 more
doaj +2 more sources
Tmod3 regulates polarized epithelial cell morphology [PDF]
Journal of Cell Science, 2007 Although the role of the actin cytoskeleton in morphogenesis of polarized epithelial sheets is generally accepted as centrally important, the regulation of actin dynamics in this process remains unclear. Here, we show that the pointed-end capping protein Tmod3 contributes to epithelial cell shape within confluent monolayers of polarized epithelial ...
Robert S Fischer +2 more
exaly +3 more sources
Evaluation of translational potential of mRNA vaccine candidate antigens for pancreatic cancer: a systematic review based on clinical evidence and stratified prioritization strategies [PDF]
Frontiers in ImmunologyPancreatic cancer is a highly aggressive malignancy with a 5-year relative survival rate of only 13%. Current treatment options have limited efficacy, and mRNA vaccines offer a new direction for its treatment.
Yuzhe Xue +11 more
doaj +2 more sources
APOE ε4 allele drives female-specific Alzheimer’s disease progression via vascular dysfunction and tau spreading [PDF]
Frontiers in NeuroscienceBackgroundApolipoprotein E (APOE) epsilon4 (ε4) is a major genetic risk factor for late-onset Alzheimer’s disease (AD), with women exhibiting heightened vulnerability to APOE ε4-associated cognitive impairment.
Shuai Huang, Jiawei Wu, Ling He
doaj +2 more sources
Genome-Wide Association Study of Conformation Traits in Brazilian Holstein Cattle [PDF]
AnimalsThe linear conformation of animals exerts an influence on health, reproduction, production, and welfare, in addition to longevity, which directly affects the profitability of milk-producing farms.
Emanueli F. P. Silva +6 more
doaj +2 more sources