Gene-Set Enrichment Analysis for Identifying Genes and Biological Activities Associated with Growth Traits in Dromedaries [PDF]
Animals, 2022 Growth is an important heritable economic trait for dromedaries and necessary for planning a successful breeding program. Until now, genome-wide association studies (GWAS) and QTL-mapping have identified significant single nucleotide polymorphisms (SNPs)
Morteza Bitaraf Sani +8 more
doaj +9 more sources
The Effects of Mild Intermittent Hypoxia Exposure on the Abdominal Subcutaneous Adipose Tissue Proteome in Overweight and Obese Men: A First-in-Human Randomized, Single-Blind, and Cross-Over Study [PDF]
Frontiers in Physiology, 2022 Adipose tissue (AT) oxygen tension (pO2) has been implicated in AT dysfunction and metabolic perturbations in both rodents and humans. Compelling evidence suggests that hypoxia exposure alters metabolism, at least partly through effects on AT.
Rens L. J. Van Meijel +5 more
doaj +4 more sources
Intra-amniotic delivery of tropomodulin 3 rescues cell apoptosis induced by miR-200b-3p upregulation via non-canonical nuclear factor kappa B pathways in ethylene thiourea induced anorectal malformations fetal rat [PDF]
Ecotoxicology and Environmental SafetyEthylene thiourea (ETU), a metabolite of the fungicide ethylene bisdithiocarbamate (EBDC), has received great concern because of its harmful effects. ETU-induced anorectal malformations (ARMs) in rat models have been reported and widely used in the study
Peiqi Liu +7 more
doaj +2 more sources
Tropomodulin’s Actin-Binding Abilities Are Required to Modulate Dendrite Development [PDF]
Frontiers in Molecular Neuroscience, 2018 There are many unanswered questions about the roles of the actin pointed end capping and actin nucleation by tropomodulins (Tmod) in regulating neural morphology.
Kevin T. Gray +13 more
doaj +6 more sources
Tmod3 participates in platelet formation and sizing in mouse fetal liver (278.9)
FASEB Journal, 2014 Tropomodulins (Tmod) bind tropomyosin and cap the pointed ends of actin filaments. Tmod3 is the only Tmod isoform detected in human and mouse platelets. To study its function in platelets we have examined platelets from Tmod3 ‐/‐
Stephanie Halene, Diane S Krause
exaly +2 more sources
Role of Tropomodulins in brain physiology and pathology [PDF]
Neurobiology of DiseaseActin dynamics are crucial for the morphogenesis and function of neurons in the brain. Tropomodulins (Tmods) belong to a family of actin-binding proteins that cap the pointed-end of actin filaments. There are four Tmod isoforms, and three of which, Tmod1,
Chuan Hong +6 more
doaj +2 more sources
Oviductal Transcriptome Is Modified after Insemination during Spontaneous Ovulation in the Sow. [PDF]
PLoS ONE, 2015 Gene Expression Microarray technology was used to compare oviduct transcriptome between inseminated and non-inseminated pigs during spontaneous oestrus.
Rebeca López-Úbeda +6 more
doaj +2 more sources
Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia. [PDF]
Hum Mol Genet, 2022 The molecular mechanisms leading to high-altitude pulmonary hypertension (HAPH) remains poorly understood. We previously analyzed the whole genome sequence of Kyrgyz highland population and identified eight genomic intervals having a potential role in ...
Stobdan T +5 more
europepmc +3 more sources