Results 41 to 50 of about 807 (128)

Additional file 8 of Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling [PDF]

, 2022
Additional file 8: Fig. S8. AEP promotes GBM progression by cleaving Tmod3. (A)Immunoblots of Tmod3, AEP, p53 and GAPDH in U87-MG and A172 cells with indicated treatments.
Keman Liao (11611105), Yongming Qiu (171424), Yingying Lin (1790404), Binghong Chen (11080383), Zhonggang Shi (12972190), Qi Lv (169217), Yan Lin (285018), Wenrui Zhang (1486636), Chunhui Ma (668361), Junjun Qiu (10462250), Jiazhou Ye (5712152), Zhongrun Qian (11645269), Rong Liang (587636), Mengying Wang (4443901)   +13 more
core   +1 more source

Proteomic Profiling of Pre- and Post-Surgery Saliva of Glioblastoma Patients: A Pilot Investigation. [PDF]

Int J Mol Sci
Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor characterized by a high infiltration capability and recurrence rate. Early diagnosis is crucial to improve the prognosis and to personalize the therapeutic approach.
Muntiu A, Moresi F, Vincenzoni F, Rossetti DV, Iavarone F, Messana I, Castagnola M, La Rocca G, Mazzucchi E, Olivi A, Urbani A, Sabatino G, Desiderio C.   +12 more
europepmc   +5 more sources

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

A gene network of uterine luminal epithelium organizes mouse blastocyst implantation

Reproductive Medicine and Biology, Volume 21, Issue 1, January/December 2022., 2022
Abstract Purpose The receptive endometrium is critical for blastocyst implantation. In mice, after blastocysts enter the uterine cavities on day 4 of pregnancy (day 1 = vaginal plug), blastocyst attachment is completed within 24 h, accompanied by dynamic interactions between the uterine luminal epithelium and the blastocysts.
Shizu Aikawa, Yasushi Hirota, Yamato Fukui, Chihiro Ishizawa, Rei IIda, Tetsuaki Kaku, Tomoyuki Hirata, Shun Akaeda, Takehiro Hiraoka, Mitsunori Matsuo, Yutaka Osuga   +10 more
wiley   +1 more source

Tropomyosin-binding properties modulate competition between tropomodulin isoforms [PDF]

, 2016
The formation and fine-tuning of cytoskeleton in cells are governed by proteins that influence actin filament dynamics. Tropomodulin (Tmod) regulates the length of actin filaments by capping the pointed ends in a tropomyosin (TM)-dependent manner. Tmod1,
Colpan, Mert, Kostyukova, Alla S, Gray, Kevin T, Diaz, Christian A, Moroz, Natalia A, Cooper, Dillon A   +5 more
core   +1 more source

Cytoplasmic γ-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers [PDF]

, 2011
The sarcoplasmic reticulum (SR) serves as the Ca2+ reservoir for muscle contraction. Tropomodulins (Tmods) cap filamentous actin (F-actin) pointed ends, bind tropomyosins (Tms), and regulate F-actin organization. In this paper, we use a genetic targeting
Velia M. Fowler, David S. Gokhin
core   +1 more source

Tropomodulins Control the Balance between Protrusive and Contractile Structures by Stabilizing Actin-Tropomyosin Filaments [PDF]

, 2020
Eukaryotic cells have diverse protrusive and contractile actin filament structures, which compete with one another for a limited pool of actin monomers.
Kumari, Reena, Jiu, Yaming, Varjosalo, Markku, Lappalainen, Pekka, Tojkander, Sari, Dominguez, Roberto, Carman, Peter J., Gunning, Peter W., Kogan, Konstantin   +8 more
core   +1 more source

Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton. [PDF]

, 2010
The short actin filaments in the red blood cell (RBC) membrane skeleton are capped at their pointed ends by tropomodulin 1 (Tmod1) and coated with tropomyosin (TM) along their length.
Kuypers, F A, Sandra K. Larkin, Nowak, R B, Hartwig, J, Fowler, V M, John Hartwig, Kim, N E, Luanne L. Peters, Peters, L L, Roberta B. Nowak, Jeannette D. Moyer, Velia M. Fowler, Larkin, S K, Frans A. Kuypers, Moyer, J D, Nancy E. Kim   +15 more
core   +1 more source

Supplementary Figures from LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion [PDF]

, 2019
Supplementary Figure S1-S9. Figure S1. Specificity of antibody directed against the L2Δ13 splice form of LOXL2 in histological analysis. Figure S2. LOXL2 and L2Δ13 promote ESCC cell migration and invasion. Figure S3.
Li-Yan Xu (216067), Shao-Hong Wang (621143), Run-Liu Li (14934534), En-Min Li (621149), Jian-Yi Wu (621144), Jian-Zhong He (4831422), Lian-Di Liao (730524), Hai-Feng Zhang (3059928), Yin-Wei Cheng (7462262), Hai-Ying Zou (11714183), Zhi-Yong Wu (621148), Xiu-E Xu (621146), Kai Zhang (102844), Juan-Juan Wang (1468963), Gera Neufeld (14934537), Xiu-Hui Zhan (608361), Ji-Wei Jiao (608360)   +16 more
core   +1 more source

Alteration of Tropomyosin-binding Properties of Tropomodulin-1 Affects Its Capping Ability and Localization in Skeletal Myocytes [PDF]

, 2013
Tropomodulin (Tmod) is an actin-capping protein that binds to the two tropomyosins (TM) at the pointed end of the actin filament to prevent further actin polymerization and depolymerization.
Moroz, Natalia A., Azevedo, Ricardo, Kostyukova, Alla S., Gregorio, Carol C., Uversky, Vladimir N, Moroz, Natalia A, Novak, Stefanie M., Kostyukova, Alla S, Azevedo, Richardo, Uversky, Vladimir N., Novak, Stefanie M, Gregorio, Carol C, Colpan, Mert   +12 more
core   +1 more source