Results 41 to 50 of about 845 (125)

Additional file 7 of Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling

, 2022
Additional file 7: Fig. S7. AEP promotes GBM progression by cleaving Tmod3 in vitro and in vivo. (A) CCK-8 assays of U87-MG and A172 cells with NC, AEP KD, AEP KD/tTmod3-N res, AEP KD/tTmod3-C res and AEP KD/tTmod3-N res/tTmod3-C res.
Keman Liao (11611105), Yongming Qiu (171424), Yingying Lin (1790404), Binghong Chen (11080383), Zhonggang Shi (12972190), Qi Lv (169217), Yan Lin (285018), Wenrui Zhang (1486636), Chunhui Ma (668361), Junjun Qiu (10462250), Jiazhou Ye (5712152), Zhongrun Qian (11645269), Rong Liang (587636), Mengying Wang (4443901)   +13 more
core   +1 more source

Additional file 9 of Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling

, 2022
Additional file 9: Fig. S9.Rescue of truncations of Tmod3 has limited effects on lysosomes in GBM cells.Representative images showing lysosomal status of indicated U87-MG and A172 cells (left panel) with quantification (right panel).
Keman Liao (11611105), Yongming Qiu (171424), Yingying Lin (1790404), Binghong Chen (11080383), Zhonggang Shi (12972190), Qi Lv (169217), Yan Lin (285018), Wenrui Zhang (1486636), Chunhui Ma (668361), Junjun Qiu (10462250), Jiazhou Ye (5712152), Zhongrun Qian (11645269), Rong Liang (587636), Mengying Wang (4443901)   +13 more
core   +1 more source

Proteomic Screening for Cellular Targets of the Duck Enteritis Virus Protein VP26 Reveals That the Host Actin-Myosin II Network Regulates the Proliferation of the Virus. [PDF]

Int J Mol Sci
Duck enteritis virus (DEV) is responsible for duck viral enteritis, a contagious and lethal disease in waterfowls. The host proteins targeted by DEV are unknown.
Chen L, Zhu YC, Yun T, Ye WC, Ni Z, Hua JG, Zhang C.   +6 more
europepmc   +2 more sources

Oviductal Transcriptome Is Modified after Insemination during Spontaneous Ovulation in the Sow.

PLoS ONE, 2015
Gene Expression Microarray technology was used to compare oviduct transcriptome between inseminated and non-inseminated pigs during spontaneous oestrus.
Rebeca López-Úbeda, Francisco A García-Vázquez, Raquel Romar, Joaquín Gadea, Marta Muñoz, Ronald H F Hunter, Pilar Coy   +6 more
doaj   +1 more source

HTLV‐1 Tax Reshapes the DNA‐Binding Pattern of Transcription Factor IRF4 and Disrupts Host Gene Regulation

Cancer Science, Volume 117, Issue 5, Page 1497-1509, May 2026.
Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Shu Tosaka, Jun Mizuike, Motomu Yano, Kaoru Uchimaru, Makoto Yamagishi   +4 more
wiley   +1 more source

Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton.

, 2010
The short actin filaments in the red blood cell (RBC) membrane skeleton are capped at their pointed ends by tropomodulin 1 (Tmod1) and coated with tropomyosin (TM) along their length.
Kuypers, F A, Sandra K. Larkin, Nowak, R B, Hartwig, J, Fowler, V M, John Hartwig, Kim, N E, Luanne L. Peters, Peters, L L, Roberta B. Nowak, Jeannette D. Moyer, Velia M. Fowler, Larkin, S K, Frans A. Kuypers, Moyer, J D, Nancy E. Kim   +15 more
core   +2 more sources

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

Tropomodulins Control the Balance between Protrusive and Contractile Structures by Stabilizing Actin-Tropomyosin Filaments [PDF]

, 2020
Eukaryotic cells have diverse protrusive and contractile actin filament structures, which compete with one another for a limited pool of actin monomers.
Kumari, Reena, Jiu, Yaming, Varjosalo, Markku, Lappalainen, Pekka, Tojkander, Sari, Dominguez, Roberto, Carman, Peter J., Gunning, Peter W., Kogan, Konstantin   +8 more
core   +1 more source

Risk of Alzheimer's disease in Down syndrome: Insights gained by multi‐omics

Alzheimer's &Dementia, Volume 21, Issue 4, April 2025.
Abstract Individuals with Down syndrome (DS) are highly susceptible to Alzheimer's disease (AD). The integration of genomics, transcriptomics, epigenomics, proteomics, and metabolomics enables unprecedented understanding of DS‐AD, offering a detailed picture of this complex issue. The vast ‐omics data also present challenges that reflect the complexity
Hui‐Qi Qu, Yichuan Liu, John J. Connolly, Frank D. Mentch, Charlly Kao, Hakon Hakonarson   +5 more
wiley   +1 more source

Cytoplasmic γ-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers

, 2011
The sarcoplasmic reticulum (SR) serves as the Ca2+ reservoir for muscle contraction. Tropomodulins (Tmods) cap filamentous actin (F-actin) pointed ends, bind tropomyosins (Tms), and regulate F-actin organization. In this paper, we use a genetic targeting
Velia M. Fowler, David S. Gokhin
core   +1 more source