Results 51 to 60 of about 807 (128)

Molecular Pathogenesis of Pancreatic Ductal Adenocarcinoma: Impact of miR-30c-5p and miR-30c-2-3p Regulation on Oncogenic Genes [PDF]

, 2020
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of cancer, and its prognosis is abysmal; only 25% of patients survive one year, and 5% live for five years. MicroRNA (miRNA) signature analysis of PDAC revealed that both strands
Masumi Wada, Tetsuya Idichi, Takako Tanaka, Hiroshi Kurahara, Takao Ohtsuka, Naohiko Seki, Reona Okada, Yuto Hozaka, Shogo Moriya, Souichi Satake   +9 more
core   +1 more source

HTLV‐1 Tax Reshapes the DNA‐Binding Pattern of Transcription Factor IRF4 and Disrupts Host Gene Regulation

Cancer Science, Volume 117, Issue 5, Page 1497-1509, May 2026.
Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Shu Tosaka, Jun Mizuike, Motomu Yano, Kaoru Uchimaru, Makoto Yamagishi   +4 more
wiley   +1 more source

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

Risk of Alzheimer's disease in Down syndrome: Insights gained by multi‐omics

Alzheimer's &Dementia, Volume 21, Issue 4, April 2025.
Abstract Individuals with Down syndrome (DS) are highly susceptible to Alzheimer's disease (AD). The integration of genomics, transcriptomics, epigenomics, proteomics, and metabolomics enables unprecedented understanding of DS‐AD, offering a detailed picture of this complex issue. The vast ‐omics data also present challenges that reflect the complexity
Hui‐Qi Qu, Yichuan Liu, John J. Connolly, Frank D. Mentch, Charlly Kao, Hakon Hakonarson   +5 more
wiley   +1 more source

Tissue‐specific methylomic responses to a lifestyle intervention in older adults associate with metabolic and physiological health improvements

Aging Cell, Volume 24, Issue 4, April 2025.
Diet and physical activity influence immunometabolic health across the lifespan, and DNA methylation may mediate a part of these effects. The Growing Old Together (GOTO) study, a 13‐week lifestyle intervention in older adults, revealed epigenetic changes in muscle, adipose, and blood at hundreds of CpGs, linking these to differential gene expression ...
Lucy Sinke, Marian Beekman, Yotam Raz, Thies Gehrmann, Ioannis Moustakas, Alexis Boulinguiez, Nico Lakenberg, Eka Suchiman, Fatih A. Bogaards, Daniele Bizzarri, Erik B. van den Akker, Melanie Waldenberger, Gillian Butler‐Browne, Capucine Trollet, C. P. G. M. de Groot, Bastiaan T. Heijmans, P. Eline Slagboom   +16 more
wiley   +1 more source

Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers [PDF]

, 2014
In skeletal muscle, thick and thin filaments are arranged in a myofibrillar lattice. Tropomodulin 1 (Tmod1) is a pointed-end capping and tropomyosin-binding protein that controls thin-filament assembly, stability, and lengths.
Ochala, Julien; id_orcid, Iwamoto, Hiroyuki, Fowler, Velia M, Gokhin, David S   +3 more
core   +1 more source

Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 1, February 2025.
ABSTRACT Background Recent studies provide strong evidence for a key role of skeletal muscle pathophysiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In a 2021 review article on the pathophysiology of ME/CFS, we postulated that hypoperfusion and ischemia can result in excessive sodium and calcium overload in skeletal muscles of ...
Carmen Scheibenbogen, Klaus J. Wirth
wiley   +1 more source

Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers

Alzheimer's &Dementia, Volume 20, Issue 11, Page 7698-7714, November 2024.
Abstract INTRODUCTION MicroRNAs (miRNAs) play important roles in gene expression regulation and Alzheimer's disease (AD) pathogenesis. METHODS We investigated the association between baseline plasma miRNAs and central AD biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 803): amyloid, tau, and neurodegeneration (A/T/N ...
Shiwei Liu, Tamina Park, Dennis M. Krüger, Tonatiuh Pena‐Centeno, Susanne Burkhardt, Anna‐Lena Schutz, Yen‐Ning Huang, Thea Rosewood, Soumilee Chaudhuri, MinYoung Cho, Shannon L. Risacher, Yang Wan, Leslie M. Shaw, Farahnaz Sananbenesi, Alexander S. Brodsky, Honghuang Lin, Andre Krunic, Jan Krzysztof Blusztajn, Andrew J. Saykin, Ivana Delalle, Andre Fischer, Kwangsik Nho, for the Alzheimer's Disease Neuroimaging Initiative   +22 more
wiley   +1 more source

Image_4_Tropomodulin’s Actin-Binding Abilities Are Required to Modulate Dendrite Development.TIF [PDF]

, 2018
There are many unanswered questions about the roles of the actin pointed end capping and actin nucleation by tropomodulins (Tmod) in regulating neural morphology.
Holly Stefen (4598191), Christopher J. Keller (5830580), Gary A. Wayman (359360), Mert Colpan (2618668), Thu N. A. Ly (5830577), Thomas Fath (739764), Kevin T. Gray (5830574), Alla S. Kostyukova (240631), Edward Pate (2901038)   +8 more
core   +1 more source

From sweat to hope: The role of exercise‐induced extracellular vesicles in cancer prevention and treatment

Journal of Extracellular Vesicles, Volume 13, Issue 8, August 2024.
Abstract The benefits of regular physical exercise on cancer prevention, as well as reducing fatigue, treatment side effects and recurrence, and improving quality of life and overall survival of cancer patients, are increasingly recognised. Initial studies showed that the concentration of extracellular vesicles (EVs) increases during physical activity ...
Alicia Llorente, Agnese Brokāne, Agata Mlynska, Marju Puurand, Krizia Sagini, Signe Folkmane, Marit Hjorth, Beatriz Martin‐Gracia, Silvana Romero, Diana Skorinkina, Mārtiņš Čampa, Rūdolfs Cešeiko, Nadezhda Romanchikova, Aija Kļaviņa, Tuuli Käämbre, Aija Linē   +15 more
wiley   +1 more source