Results 51 to 60 of about 845 (125)

Tissue‐specific methylomic responses to a lifestyle intervention in older adults associate with metabolic and physiological health improvements

Aging Cell, Volume 24, Issue 4, April 2025.
Diet and physical activity influence immunometabolic health across the lifespan, and DNA methylation may mediate a part of these effects. The Growing Old Together (GOTO) study, a 13‐week lifestyle intervention in older adults, revealed epigenetic changes in muscle, adipose, and blood at hundreds of CpGs, linking these to differential gene expression ...
Lucy Sinke, Marian Beekman, Yotam Raz, Thies Gehrmann, Ioannis Moustakas, Alexis Boulinguiez, Nico Lakenberg, Eka Suchiman, Fatih A. Bogaards, Daniele Bizzarri, Erik B. van den Akker, Melanie Waldenberger, Gillian Butler‐Browne, Capucine Trollet, C. P. G. M. de Groot, Bastiaan T. Heijmans, P. Eline Slagboom   +16 more
wiley   +1 more source

Additional file 8 of Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling

, 2022
Additional file 8: Fig. S8. AEP promotes GBM progression by cleaving Tmod3. (A)Immunoblots of Tmod3, AEP, p53 and GAPDH in U87-MG and A172 cells with indicated treatments.
Keman Liao (11611105), Yongming Qiu (171424), Yingying Lin (1790404), Binghong Chen (11080383), Zhonggang Shi (12972190), Qi Lv (169217), Yan Lin (285018), Wenrui Zhang (1486636), Chunhui Ma (668361), Junjun Qiu (10462250), Jiazhou Ye (5712152), Zhongrun Qian (11645269), Rong Liang (587636), Mengying Wang (4443901)   +13 more
core   +1 more source

Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 1, February 2025.
ABSTRACT Background Recent studies provide strong evidence for a key role of skeletal muscle pathophysiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In a 2021 review article on the pathophysiology of ME/CFS, we postulated that hypoperfusion and ischemia can result in excessive sodium and calcium overload in skeletal muscles of ...
Carmen Scheibenbogen, Klaus J. Wirth
wiley   +1 more source

Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers

Alzheimer's &Dementia, Volume 20, Issue 11, Page 7698-7714, November 2024.
Abstract INTRODUCTION MicroRNAs (miRNAs) play important roles in gene expression regulation and Alzheimer's disease (AD) pathogenesis. METHODS We investigated the association between baseline plasma miRNAs and central AD biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 803): amyloid, tau, and neurodegeneration (A/T/N ...
Shiwei Liu, Tamina Park, Dennis M. Krüger, Tonatiuh Pena‐Centeno, Susanne Burkhardt, Anna‐Lena Schutz, Yen‐Ning Huang, Thea Rosewood, Soumilee Chaudhuri, MinYoung Cho, Shannon L. Risacher, Yang Wan, Leslie M. Shaw, Farahnaz Sananbenesi, Alexander S. Brodsky, Honghuang Lin, Andre Krunic, Jan Krzysztof Blusztajn, Andrew J. Saykin, Ivana Delalle, Andre Fischer, Kwangsik Nho, for the Alzheimer's Disease Neuroimaging Initiative   +22 more
wiley   +1 more source

From sweat to hope: The role of exercise‐induced extracellular vesicles in cancer prevention and treatment

Journal of Extracellular Vesicles, Volume 13, Issue 8, August 2024.
Abstract The benefits of regular physical exercise on cancer prevention, as well as reducing fatigue, treatment side effects and recurrence, and improving quality of life and overall survival of cancer patients, are increasingly recognised. Initial studies showed that the concentration of extracellular vesicles (EVs) increases during physical activity ...
Alicia Llorente, Agnese Brokāne, Agata Mlynska, Marju Puurand, Krizia Sagini, Signe Folkmane, Marit Hjorth, Beatriz Martin‐Gracia, Silvana Romero, Diana Skorinkina, Mārtiņš Čampa, Rūdolfs Cešeiko, Nadezhda Romanchikova, Aija Kļaviņa, Tuuli Käämbre, Aija Linē   +15 more
wiley   +1 more source

Optimization of ultracentrifugation‐based method to enhance the purity and proteomic profiling depth of plasma‐derived extracellular vesicles and particles

Journal of Extracellular Biology, Volume 3, Issue 7, July 2024.
Abstract Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasma has posed a challenge of in‐depth analysis of the EVP proteome. Here, we compared the effectiveness of
Zurong Wan, Jinghua Gu, Uthra Balaji, Linda Bojmar, Henrik Molina, Søren Heissel, Alexandra E. Pagano, Christopher Peralta, Lee Shaashua, Dorina Ismailgeci, Hope K. Narozniak, Yi Song, William R. Jarnagin, David P. Kelsen, Jaqueline Bromberg, Virginia Pascual, Haiying Zhang   +16 more
wiley   +1 more source

Differential effects of physiological agonists on the proteome of platelet‐derived extracellular vesicles

PROTEOMICS, Volume 24, Issue 11, June 2024.
Abstract Arterial thrombosis manifesting as heart attack and stroke is the leading cause of death worldwide. Platelets are central mediators of thrombosis that can be activated through multiple activation pathways. Platelet‐derived extracellular vesicles (pEVs), also known as platelet‐derived microparticles, are granular mixtures of membrane structures
Mitchell J. Moon, Alin Rai, Prerna Sharma, Haoyun Fang, James D. McFadyen, David W. Greening, Karlheinz Peter   +6 more
wiley   +1 more source

RETRACTED: Exploration of the causality of frailty index on psoriasis: A Mendelian randomization study

Skin Research and Technology, Volume 30, Issue 3, March 2024.
Abstract Background Frailty is associated with a variety of diseases, but the relationship between frailty and psoriasis remains unclear. Methods First, we conducted a two‐sample Mendelian randomization based on genome‐wide association studies (GWAS) to investigate genetic causality between frailty index and common diseases in dermatology.
Hao Lei, Zixuan Xing, Xin Chen, Yilin Dai, Baochen Cheng, Shengbang Wang, Tong Kang, Qian Wang, Jing Zhang, Jinjing Jia, Yan Zheng   +10 more
wiley   +1 more source

Supplementary Figures from LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion

, 2019
Supplementary Figure S1-S9. Figure S1. Specificity of antibody directed against the L2Δ13 splice form of LOXL2 in histological analysis. Figure S2. LOXL2 and L2Δ13 promote ESCC cell migration and invasion. Figure S3.
Li-Yan Xu (216067), Shao-Hong Wang (621143), Run-Liu Li (14934534), En-Min Li (621149), Jian-Yi Wu (621144), Jian-Zhong He (4831422), Lian-Di Liao (730524), Hai-Feng Zhang (3059928), Yin-Wei Cheng (7462262), Hai-Ying Zou (11714183), Zhi-Yong Wu (621148), Xiu-E Xu (621146), Kai Zhang (102844), Juan-Juan Wang (1468963), Gera Neufeld (14934537), Xiu-Hui Zhan (608361), Ji-Wei Jiao (608360)   +16 more
core   +1 more source

Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise

Journal of Extracellular Vesicles, Volume 13, Issue 1, January 2024.
Abstract In healthy individuals, physical exercise improves cardiovascular health and muscle strength, alleviates fatigue and reduces the risk of chronic diseases. Although exercise is suggested as a lifestyle intervention to manage various chronic illnesses, it negatively affects people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS),
Ludovic Giloteaux, Katherine A. Glass, Arnaud Germain, Carl J. Franconi, Sheng Zhang, Maureen R. Hanson   +5 more
wiley   +1 more source