Results 61 to 70 of about 845 (125)

Alteration of Tropomyosin-binding Properties of Tropomodulin-1 Affects Its Capping Ability and Localization in Skeletal Myocytes

, 2013
Tropomodulin (Tmod) is an actin-capping protein that binds to the two tropomyosins (TM) at the pointed end of the actin filament to prevent further actin polymerization and depolymerization.
Moroz, Natalia A., Azevedo, Ricardo, Kostyukova, Alla S., Gregorio, Carol C., Uversky, Vladimir N, Moroz, Natalia A, Novak, Stefanie M., Kostyukova, Alla S, Azevedo, Richardo, Uversky, Vladimir N., Novak, Stefanie M, Gregorio, Carol C, Colpan, Mert   +12 more
core   +1 more source

Role of Tropomodulin’s Leucine Rich Repeat Domain in the Formation of Neurite-like Processes [PDF]

, 2014
Actin dynamics is fundamental for neurite development; monomer depolymerization from pointed ends is rate-limiting in actin treadmilling. Tropomodulins (Tmod) make up a family of actin pointed end-capping proteins. Of the four known isoforms, Tmod1–Tmod3
Kostyukova, Alla S, Gray, Kevin T, Moroz, Natalia, Pate, Edward, Pantazis, Caroline, Guillaud, Laurent   +5 more
core   +1 more source

Molecular Pathogenesis of Pancreatic Ductal Adenocarcinoma: Impact of miR-30c-5p and miR-30c-2-3p Regulation on Oncogenic Genes

, 2020
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of cancer, and its prognosis is abysmal; only 25% of patients survive one year, and 5% live for five years. MicroRNA (miRNA) signature analysis of PDAC revealed that both strands
Masumi Wada, Tetsuya Idichi, Takako Tanaka, Hiroshi Kurahara, Takao Ohtsuka, Naohiko Seki, Reona Okada, Yuto Hozaka, Shogo Moriya, Souichi Satake   +9 more
core   +1 more source

Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders [PDF]

, 2019
The Central Asian Kyrgyz highland population provides a unique opportunity to address genetic diversity and understand the genetic mechanisms underlying high-altitude pulmonary hypertension (HAPH).
Kirkness, Ewen F, Ewen F. Kirkness, Arya Iranmehr, Venter, J Craig, Orit Poulsen, Haddad, Gabriel G, Kingman P. Strohl, Emily H. M. Wong, Gabriel G. Haddad, Strohl, Kingman P, Telenti, Amalio, J. Craig Venter, Tsering Stobdan, Amalio Telenti, Aldashev, Almaz, Dan Zhou, Iranmehr, Arya, Bafna, Vineet, Vineet Bafna, Poulsen, Orit, Zhou, Dan, Wong, Emily HM, Almaz Aldashev, Stobdan, Tsering   +23 more
core   +1 more source

Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers

, 2014
In skeletal muscle, thick and thin filaments are arranged in a myofibrillar lattice. Tropomodulin 1 (Tmod1) is a pointed-end capping and tropomyosin-binding protein that controls thin-filament assembly, stability, and lengths.
Ochala, Julien; id_orcid, Iwamoto, Hiroyuki, Fowler, Velia M, Gokhin, David S   +3 more
core   +1 more source

Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle [PDF]

, 2020
Duchenne muscular dystrophy (DMD) induces sarcolemmal mechanical instability and rupture, hyperactivity of intracellular calpains, and proteolytic breakdown of muscle structural proteins.
Velia M Fowler, Matthew T Tierney, Zhenhua Sui, David S Gokhin, Alessandra Sacco   +4 more
core  

Image_5_Tropomodulin’s Actin-Binding Abilities Are Required to Modulate Dendrite Development.TIF

, 2018
There are many unanswered questions about the roles of the actin pointed end capping and actin nucleation by tropomodulins (Tmod) in regulating neural morphology.
Holly Stefen (4598191), Christopher J. Keller (5830580), Gary A. Wayman (359360), Mert Colpan (2618668), Thu N. A. Ly (5830577), Thomas Fath (739764), Kevin T. Gray (5830574), Alla S. Kostyukova (240631), Edward Pate (2901038)   +8 more
core   +1 more source

Pathway-based analyses of common differentially expressed genes in BE vs NE and BE vs NC comparisons.

, 2014
Two hundred and five overlapping genes were identified between BE vs. NE and BE vs.
Paula L. Hyland (447513), Nan Hu (4067), Christian C. Abnet (190748), Patrick E. Young (548862), Kathryn M. Johnson (548860), Barbara Gherman (548858), Carol Giffen (14953), Chaoyu Wang (14952), Brooks D. Cash (548863), Sanford M. Dawsey (190745), Ruth M. Pfeiffer (106774), Melissa Rotunno (263804), Lemin Wang (414472), Hua Su (22590), Ruben D. Acosta (548861), Cathy Dykes (548859), Philip R. Taylor (132020)   +16 more
core   +1 more source

Image_1_Tropomodulin’s Actin-Binding Abilities Are Required to Modulate Dendrite Development.TIF

, 2018
There are many unanswered questions about the roles of the actin pointed end capping and actin nucleation by tropomodulins (Tmod) in regulating neural morphology.
Holly Stefen (4598191), Christopher J. Keller (5830580), Gary A. Wayman (359360), Mert Colpan (2618668), Thu N. A. Ly (5830577), Thomas Fath (739764), Kevin T. Gray (5830574), Alla S. Kostyukova (240631), Edward Pate (2901038)   +8 more
core   +1 more source

Image_4_Tropomodulin’s Actin-Binding Abilities Are Required to Modulate Dendrite Development.TIF

, 2018
There are many unanswered questions about the roles of the actin pointed end capping and actin nucleation by tropomodulins (Tmod) in regulating neural morphology.
Holly Stefen (4598191), Christopher J. Keller (5830580), Gary A. Wayman (359360), Mert Colpan (2618668), Thu N. A. Ly (5830577), Thomas Fath (739764), Kevin T. Gray (5830574), Alla S. Kostyukova (240631), Edward Pate (2901038)   +8 more
core   +1 more source