Results 61 to 70 of about 807 (128)

Data_Sheet_1_The Effects of Mild Intermittent Hypoxia Exposure on the Abdominal Subcutaneous Adipose Tissue Proteome in Overweight and Obese Men: A First-in-Human Randomized, Single-Blind, and Cross-Over Study.pdf [PDF]

, 2022
Adipose tissue (AT) oxygen tension (pO2) has been implicated in AT dysfunction and metabolic perturbations in both rodents and humans. Compelling evidence suggests that hypoxia exposure alters metabolism, at least partly through effects on AT.
Edwin C. M. Mariman (7460948), Rens L. J. Van Meijel (11898266), Ping Wang (42415), Gijs H. Goossens (11050371), Freek Bouwman (3512495), Ellen E. Blaak (10510529)   +5 more
core   +1 more source

Optimization of ultracentrifugation‐based method to enhance the purity and proteomic profiling depth of plasma‐derived extracellular vesicles and particles

Journal of Extracellular Biology, Volume 3, Issue 7, July 2024.
Abstract Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasma has posed a challenge of in‐depth analysis of the EVP proteome. Here, we compared the effectiveness of
Zurong Wan, Jinghua Gu, Uthra Balaji, Linda Bojmar, Henrik Molina, Søren Heissel, Alexandra E. Pagano, Christopher Peralta, Lee Shaashua, Dorina Ismailgeci, Hope K. Narozniak, Yi Song, William R. Jarnagin, David P. Kelsen, Jaqueline Bromberg, Virginia Pascual, Haiying Zhang   +16 more
wiley   +1 more source

Differential effects of physiological agonists on the proteome of platelet‐derived extracellular vesicles

PROTEOMICS, Volume 24, Issue 11, June 2024.
Abstract Arterial thrombosis manifesting as heart attack and stroke is the leading cause of death worldwide. Platelets are central mediators of thrombosis that can be activated through multiple activation pathways. Platelet‐derived extracellular vesicles (pEVs), also known as platelet‐derived microparticles, are granular mixtures of membrane structures
Mitchell J. Moon, Alin Rai, Prerna Sharma, Haoyun Fang, James D. McFadyen, David W. Greening, Karlheinz Peter   +6 more
wiley   +1 more source

RETRACTED: Exploration of the causality of frailty index on psoriasis: A Mendelian randomization study

Skin Research and Technology, Volume 30, Issue 3, March 2024.
Abstract Background Frailty is associated with a variety of diseases, but the relationship between frailty and psoriasis remains unclear. Methods First, we conducted a two‐sample Mendelian randomization based on genome‐wide association studies (GWAS) to investigate genetic causality between frailty index and common diseases in dermatology.
Hao Lei, Zixuan Xing, Xin Chen, Yilin Dai, Baochen Cheng, Shengbang Wang, Tong Kang, Qian Wang, Jing Zhang, Jinjing Jia, Yan Zheng   +10 more
wiley   +1 more source

Pathway-based analyses of common differentially expressed genes in BE vs NE and BE vs NC comparisons. [PDF]

, 2014
Two hundred and five overlapping genes were identified between BE vs. NE and BE vs.
Paula L. Hyland (447513), Nan Hu (4067), Christian C. Abnet (190748), Patrick E. Young (548862), Kathryn M. Johnson (548860), Barbara Gherman (548858), Carol Giffen (14953), Chaoyu Wang (14952), Brooks D. Cash (548863), Sanford M. Dawsey (190745), Ruth M. Pfeiffer (106774), Melissa Rotunno (263804), Lemin Wang (414472), Hua Su (22590), Ruben D. Acosta (548861), Cathy Dykes (548859), Philip R. Taylor (132020)   +16 more
core   +1 more source

Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise

Journal of Extracellular Vesicles, Volume 13, Issue 1, January 2024.
Abstract In healthy individuals, physical exercise improves cardiovascular health and muscle strength, alleviates fatigue and reduces the risk of chronic diseases. Although exercise is suggested as a lifestyle intervention to manage various chronic illnesses, it negatively affects people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS),
Ludovic Giloteaux, Katherine A. Glass, Arnaud Germain, Carl J. Franconi, Sheng Zhang, Maureen R. Hanson   +5 more
wiley   +1 more source

Image_5_Tropomodulin’s Actin-Binding Abilities Are Required to Modulate Dendrite Development.TIF [PDF]

, 2018
There are many unanswered questions about the roles of the actin pointed end capping and actin nucleation by tropomodulins (Tmod) in regulating neural morphology.
Holly Stefen (4598191), Christopher J. Keller (5830580), Gary A. Wayman (359360), Mert Colpan (2618668), Thu N. A. Ly (5830577), Thomas Fath (739764), Kevin T. Gray (5830574), Alla S. Kostyukova (240631), Edward Pate (2901038)   +8 more
core   +1 more source

Tropomodulin isoforms utilize specific binding functions to modulate dendrite development [PDF]

, 2016
Tropomodulins (Tmods) cap F-actin pointed ends and have altered expression in the brain in neurological diseases. The function of Tmods in neurons has been poorly studied and their role in neurological diseases is entirely unknown.
Thomas Fath, Wayman, Gary, Alexandra K. Suchowerska, Alla S. Kostyukova, Fath, Thomas, Tyler Bland, Colpan, Mert, Kostyukova, Alla S, Gray, Kevin T, Mert Colpan, Kevin T. Gray, Bland, Tyler, Gary Wayman, Suchowerska, Alexandra K   +13 more
core   +1 more source

Role of Tropomodulin’s Leucine Rich Repeat Domain in the Formation of Neurite-like Processes [PDF]

, 2014
Actin dynamics is fundamental for neurite development; monomer depolymerization from pointed ends is rate-limiting in actin treadmilling. Tropomodulins (Tmod) make up a family of actin pointed end-capping proteins. Of the four known isoforms, Tmod1–Tmod3
Kostyukova, Alla S, Gray, Kevin T, Moroz, Natalia, Pate, Edward, Pantazis, Caroline, Guillaud, Laurent   +5 more
core   +1 more source

Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders [PDF]

, 2019
The Central Asian Kyrgyz highland population provides a unique opportunity to address genetic diversity and understand the genetic mechanisms underlying high-altitude pulmonary hypertension (HAPH).
Kirkness, Ewen F, Ewen F. Kirkness, Arya Iranmehr, Venter, J Craig, Orit Poulsen, Haddad, Gabriel G, Kingman P. Strohl, Emily H. M. Wong, Gabriel G. Haddad, Strohl, Kingman P, Telenti, Amalio, J. Craig Venter, Tsering Stobdan, Amalio Telenti, Aldashev, Almaz, Dan Zhou, Iranmehr, Arya, Bafna, Vineet, Vineet Bafna, Poulsen, Orit, Zhou, Dan, Wong, Emily HM, Almaz Aldashev, Stobdan, Tsering   +23 more
core   +1 more source