Additional file 2 of Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling [PDF]
, 2022 Additional file 2: Fig. S2. AEP binds to Tmod3 and specifically cleaves Tmod3 at N157. (A) Immunoblots of Flag-tagged Tmod3, AEP and GAPDH in HEK293 cells co-transfected with AEP and panels of Tmod3 point mutants.
Keman Liao (11611105) +13 more
core +1 more source
Additional file 5 of Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling [PDF]
, 2022 Additional file 5: Fig. S5. AEP produced Tmod3 truncations exist in many types of solid tumors. (A, B) Immunoblots of Tmod3, AEP and GAPDH in HGG tissues.(C) Immunoblots of Tmod3, AEP and GAPDH in LGG tissues.
Keman Liao (11611105) +13 more
core +1 more source
Additional file 10 of Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling [PDF]
, 2022 Additional file 10: Fig. S10.Correlation analysis of Tmod3 and SND1/RhoA signaling. (A) The relative expression of LGMN, TMOD3, ACTB, SND1, RHOA and CDK1 in GBM compared to normal brain tissues by GEPIA analysis.
Keman Liao (11611105) +13 more
core +1 more source
Additional file 4 of Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling [PDF]
, 2022 Additional file 4: Fig. S4. Suppression of Tmod3 inhibits tumor progression. (A) Representative images showing lysosomal status of U87-MG and A172 cells with or without Tmod3 KD (left panel) with quantification (right panel). Scale bar, 100 μm.
Keman Liao (11611105) +13 more
core +1 more source
Advances in Cancer Biology - Metastasis, 2021 Background: Oral cancer is one of the highly aggravated conditions of oral pathologies. The commonly diagnosed form of oral cancer is oral squamous cell carcinoma (OSCC).
Sapna Khowal +4 more
doaj +1 more source
Actin Filament Pointed Ends: Assays for Regulation of Assembly and Disassembly by Tropomodulin and Tropomyosin. [PDF]
Cytoskeleton (Hoboken)ABSTRACT Actin filaments are dynamic polymers whose length depends on regulated monomer association and dissociation at their ends. Actin barbed‐end dynamics are relatively better understood, primarily due to the approximately tenfold faster subunit on/off rates at barbed versus pointed ends.
Yamashiro S +5 more
europepmc +2 more sources
Additional file 3 of Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling [PDF]
, 2022 Additional file 3: Fig. S3. Tmod3 is highly expressed in many solid tumors and associated with poor prognosis. (A) The relative expression of TMOD3 in cholangiocarcinoma(CHOL), pancreatic adenocarcinoma (PAAD)and stomach adenocarcinoma(STAD) compared to ...
Keman Liao (11611105) +13 more
core +1 more source
Omics-derived biological modules reflect tau positron emission tomography in Alzheimer's disease. [PDF]
Alzheimers Dement (N Y)Abstract BACKGROUND Tau neurofibrillary pathology is a hallmark of Alzheimer's disease (AD) and can be quantified in vivo using tau‐selective positron emission tomography (tau PET). Tau PET signal closely correlates with cognitive decline and disease stage, yet the molecular networks underpinning tau accumulation remain incompletely defined. METHODS We
Gu SC +6 more
europepmc +2 more sources
Additional file 6 of Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling [PDF]
, 2022 Additional file 6: Fig. S6. The truncated Tmod3 produced by AEP promote GBM proliferation and invasion. (A) CCK-8 assays of U87-MG and A172 cells with or without truncations of Tmod3 overexpression. (B) Representative images showing IHC staining of Tmod3,
Keman Liao (11611105) +13 more
core +1 more source
MiR-145 modulates the radiosensitivity of non-small cell lung cancer cells by suppression of TMOD3
Carcinogenesis, 2021 AbstractRadioresistance is a major problem encountered in the treatment of non-small cell lung cancer (NSCLC). Aberrant microRNA (miRNA) expression contributes to multiple cancer-associated signaling pathways and profoundly influences effects of radiotherapy (RT) in cancers.
Hang Li +5 more
openaire +2 more sources