Results 21 to 30 of about 845 (125)
Actin Filament Pointed Ends: Assays for Regulation of Assembly and Disassembly by Tropomodulin and Tropomyosin. [PDF]
Cytoskeleton (Hoboken)ABSTRACT Actin filaments are dynamic polymers whose length depends on regulated monomer association and dissociation at their ends. Actin barbed‐end dynamics are relatively better understood, primarily due to the approximately tenfold faster subunit on/off rates at barbed versus pointed ends.
Yamashiro S +5 more
europepmc +2 more sources
Molecular Cancer, 2021 Background Although mRNA vaccines have been effective against multiple cancers, their efficacy against pancreatic adenocarcinoma (PAAD) remains undefined.
Xing Huang +3 more
doaj +1 more source
Frontiers in Physiology, 2022 Adipose tissue (AT) oxygen tension (pO2) has been implicated in AT dysfunction and metabolic perturbations in both rodents and humans. Compelling evidence suggests that hypoxia exposure alters metabolism, at least partly through effects on AT.
Rens L. J. Van Meijel +5 more
doaj +1 more source
Omics-derived biological modules reflect tau positron emission tomography in Alzheimer's disease. [PDF]
Alzheimers Dement (N Y)Abstract BACKGROUND Tau neurofibrillary pathology is a hallmark of Alzheimer's disease (AD) and can be quantified in vivo using tau‐selective positron emission tomography (tau PET). Tau PET signal closely correlates with cognitive decline and disease stage, yet the molecular networks underpinning tau accumulation remain incompletely defined. METHODS We
Gu SC +6 more
europepmc +2 more sources
, 2022 Additional file 2: Fig. S2. AEP binds to Tmod3 and specifically cleaves Tmod3 at N157. (A) Immunoblots of Flag-tagged Tmod3, AEP and GAPDH in HEK293 cells co-transfected with AEP and panels of Tmod3 point mutants.
Keman Liao (11611105) +13 more
core +1 more source
, 2022 Additional file 5: Fig. S5. AEP produced Tmod3 truncations exist in many types of solid tumors. (A, B) Immunoblots of Tmod3, AEP and GAPDH in HGG tissues.(C) Immunoblots of Tmod3, AEP and GAPDH in LGG tissues.
Keman Liao (11611105) +13 more
core +1 more source
, 2022 Additional file 10: Fig. S10.Correlation analysis of Tmod3 and SND1/RhoA signaling. (A) The relative expression of LGMN, TMOD3, ACTB, SND1, RHOA and CDK1 in GBM compared to normal brain tissues by GEPIA analysis.
Keman Liao (11611105) +13 more
core +1 more source
Animal Genetics, Volume 54, Issue 6, Page 709-720, December 2023., 2023 AbstractAs a major source of protein in human diets, pig meat plays a crucial role in ensuring global food security. Key determinants of meat production refer to the chemical and physical compositions or characteristics of muscle fibers, such as the number, hypertrophy potential, fiber‐type conversion and intramuscular fat deposition.
Qingjie Zeng, Zhi‐Qiang Du
wiley +1 more source
PSMC4 promotes prostate carcinoma progression by regulating the CBX3–EGFR‐PI3K‐AKT‐mTOR pathway
Journal of Cellular and Molecular Medicine, Volume 27, Issue 16, Page 2437-2447, August 2023., 2023 Abstract Proteasome 26S subunit ATPase 4 (PSMC4) could regulate cancer progression. However, the function of PSMC4 in prostate carcinoma (PCa) progression requires further clarification. In the study, PSMC4 and chromobox 3 (CBX3) levels were verified by TCGA data and tissue microarrays.
Kaifeng Liu +5 more
wiley +1 more source
, 2022 Additional file 4: Fig. S4. Suppression of Tmod3 inhibits tumor progression. (A) Representative images showing lysosomal status of U87-MG and A172 cells with or without Tmod3 KD (left panel) with quantification (right panel). Scale bar, 100 μm.
Keman Liao (11611105) +13 more
core +1 more source