Results 21 to 30 of about 2,192 (170)
Pharmacological ResearchEvidence shows that tropomodulin 1 (TMOD1) is a powerful diagnostic marker in the progression of several cancer types. However, the regulatory mechanism of TMOD1 in tumor progression is still unclear.
Yuan Xia +16 more
doaj +2 more sources
Interaction between CDC6 and Tmod3 accelerates resistance to paclitaxel through focal adhesion assembly [PDF]
Signal Transduction and Targeted TherapyThe widespread clinical application of paclitaxel (PTX) in cancer treatment has been significantly limited by the emergence of drug resistance and the presence of drug-tolerant persister cells. To systematically identify key regulators of this resistance,
Yue Liu +9 more
doaj +2 more sources
YWHAG promotes bladder cancer metastasis by regulating TMOD3 to activate ERK1/2 and JNK phosphorylation in the MAPK pathway [PDF]
Journal of Translational MedicineObjective This study aims to investigate the molecular mechanisms by which YWHAG (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma) promotes metastasis in bladder cancer.
Tai Tian +12 more
doaj +2 more sources
Cardiac CapZ Regulation During Acute Exercise in Female Mice. [PDF]
FASEB JCapZ regulates actin addition at the barbed ends of sarcomeric actin. At rest, phosphorylated CapZIP slows addition, and dephosphorylated CapZIP promotes a wobble state to allow actin cycling. During exercise, CapZIP is dephosphorylated to permit increased actin addition at the barbed ends. Increased leiomodin binding to cardiac myofilaments stabilizes
Townsend LK, Wright D, Pyle WG.
europepmc +2 more sources
Biogeography and Climate Drive Population Divergence and Genomic Vulnerability in High Altitude Endemic Bird. [PDF]
Mol EcolABSTRACT High‐elevation systems support species adapted to extreme conditions, and their rugged terrain and variable microclimates strongly shape evolution and persistence. Yet few studies have evaluated how geography and climate jointly shape genetic diversity, local adaptation and vulnerability to environmental change.
Wang N +8 more
europepmc +2 more sources
Tropomodulins and tropomyosins: working as a team [PDF]
Journal of Muscle Research and Cell Motility, 2013 Actin filaments are major components of the cytoskeleton in eukaryotic cells and are involved in vital cellular functions such as cell motility and muscle contraction. Tmod and TM are crucial constituents of the actin filament network, making their presence indispensable in living cells.
Colpan, Mert +2 more
openaire +3 more sources
Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts
Frontiers in Endocrinology, 2021 Insulin and muscle contractions mediate glucose transporter 4 (GLUT4) translocation and insertion into the plasma membrane (PM) for glucose uptake in skeletal muscles.
Man Mohan Shrestha +5 more
doaj +1 more source
Effect of Chitosan Composite Preservative on Proteome Changes of Grass Carp Muscle during Cold Storage [PDF]
Shipin Kexue, 2023 To explore the effect of a chitosan-based preservative solution (10 mg/mL chitosan + 5 mg/mL tea polyphenol + 2 000 U/mL lysozyme) on the change in the muscle proteome of grass carp during cold storage, differential proteomic analysis of fresh fish and ...
LI Jialei, CHEN Sai, TIAN Mingli, YU Jian, LIU Yongle, WANG Faxiang
doaj +1 more source
Favorable prognostic role of tropomodulins in neuroblastoma [PDF]
Oncotarget, 2018 Neuroblastoma is a pediatric tumor of the sympatoadrenal lineage of the neural crest characterized by high molecular and clinical heterogeneity, which are the main causes of the poor response to standard multimodal therapy. The identification of new and selective biomarkers is important to improve our knowledge on the mechanisms of neuroblastoma ...
Bettinsoli P +6 more
openaire +3 more sources