Results 21 to 30 of about 2,101 (172)

Titin Isoform Size is Not Correlated with Thin Filament Length in Rat Skeletal Muscle

Frontiers in Physiology, 2014
The mechanisms controlling thin filament length in muscle remain controversial. It was recently reported that thin filament length was related to titin size, and that the latter might be involved in thin filament length determination.
Marion Lewis Greaser, Jonathan M Pleitner   +1 more
doaj   +2 more sources

Tropomyosin isoform 5b is expressed in human erythrocytes: implications of tropomodulin-TM5 or tropomodulin-TM5b complexes in the protofilament and hexagonal organization of membrane skeletons

Blood, 2000
The human erythrocyte membrane skeleton consists of hexagonal lattices with junctional complexes containing F-actin protofilaments of approximately 33-37 nm in length. We hypothesize that complexes formed by tropomodulin, a globular capping protein at the pointed end of actin filaments, and tropomyosin (TM), a rod-like molecule of approximately 33-35 ...
Sung, LA Sung, Lanping Amy, Gao, KM Gao, Ke-Ming, Yee, LJ Yee, Leland J., Temm-Grove, CJ Temm-Grove, Constance J., Helfman, DM Helfman, David M, Lin, JJC Lin, Jim J.-C., Mehrpouryan, M Mehrpouryan, Majid   +6 more
core   +4 more sources

Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of Tropomodulin 3 in red blood cells and disruption of the membrane skeleton [PDF]

Blood, 2010
AbstractThe short actin filaments in the red blood cell (RBC) membrane skeleton are capped at their pointed ends by tropomodulin 1 (Tmod1) and coated with tropomyosin (TM) along their length. Tmod1-TM control of actin filament length is hypothesized to regulate spectrin-actin lattice organization and membrane stability.
Moyer, J D, Nowak, R B, Kim, N E, Larkin, S K, Peters, L L, Hartwig, J, Kuypers, F A, Fowler, V M   +7 more
openaire   +3 more sources

Silencing of tropomodulin 1 inhibits acute myeloid leukemia cell proliferation and tumor growth by elevating karyopherin alpha 2–mediated autophagy

Pharmacological Research
Evidence shows that tropomodulin 1 (TMOD1) is a powerful diagnostic marker in the progression of several cancer types. However, the regulatory mechanism of TMOD1 in tumor progression is still unclear.
Yuan Xia, Dan Wang, Huijie Zhao, Tingyi Meng, Qingling Jiang, Zhaohai Pan, Guoli Wang, Tianyue An, Bohan Li, Sixue Bi, Huikai Wang, Jun Lu, Hongfu Liu, Haiyan Lin, Chunhua Lin, Qiusheng Zheng, Defang Li   +16 more
doaj   +2 more sources

YWHAG promotes bladder cancer metastasis by regulating TMOD3 to activate ERK1/2 and JNK phosphorylation in the MAPK pathway [PDF]

Journal of Translational Medicine
Objective This study aims to investigate the molecular mechanisms by which YWHAG (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma) promotes metastasis in bladder cancer.
Tai Tian, Shiming He, Han Hao, Bao Guan, Yanqing Gong, Jian Fan, Zhenpeng Zhu, Wenzhi Gao, Yucai Wu, Ninghan Feng, Aixiang Wang, Yuexian Guo, Xuesong Li   +12 more
doaj   +2 more sources

Cardiac CapZ Regulation During Acute Exercise in Female Mice. [PDF]

FASEB J
CapZ regulates actin addition at the barbed ends of sarcomeric actin. At rest, phosphorylated CapZIP slows addition, and dephosphorylated CapZIP promotes a wobble state to allow actin cycling. During exercise, CapZIP is dephosphorylated to permit increased actin addition at the barbed ends. Increased leiomodin binding to cardiac myofilaments stabilizes
Townsend LK, Wright D, Pyle WG.
europepmc   +2 more sources

An end in sight: tropomodulin. [PDF]

The Journal of cell biology, 1994
L M Coluccio
openaire   +3 more sources

Biogeography and Climate Drive Population Divergence and Genomic Vulnerability in High Altitude Endemic Bird. [PDF]

Mol Ecol
ABSTRACT High‐elevation systems support species adapted to extreme conditions, and their rugged terrain and variable microclimates strongly shape evolution and persistence. Yet few studies have evaluated how geography and climate jointly shape genetic diversity, local adaptation and vulnerability to environmental change.
Wang N, Ghimire P, Chhetri P, Dahal N, Yi C, Zhang T, Zhuoga S, Jiangyong Z, Lamichhaney S.   +8 more
europepmc   +2 more sources

Tropomodulin-3 [PDF]

, 2020
openaire   +2 more sources

Tropomodulins and tropomyosins: working as a team [PDF]

Journal of Muscle Research and Cell Motility, 2013
Actin filaments are major components of the cytoskeleton in eukaryotic cells and are involved in vital cellular functions such as cell motility and muscle contraction. Tmod and TM are crucial constituents of the actin filament network, making their presence indispensable in living cells.
Colpan, Mert, Moroz, Natalia, Kostyukova, Alla   +2 more
openaire   +3 more sources