Results 31 to 40 of about 2,192 (170)

Leiomodin creates a leaky cap at the pointed end of actin-thin filaments.

PLoS Biology, 2020
Improper lengths of actin-thin filaments are associated with altered contractile activity and lethal myopathies. Leiomodin, a member of the tropomodulin family of proteins, is critical in thin filament assembly and maintenance; however, its role is under
Dmitri Tolkatchev, Garry E Smith, Lauren E Schultz, Mert Colpan, Gregory L Helms, John R Cort, Carol C Gregorio, Alla S Kostyukova   +7 more
doaj   +1 more source

Tropomodulin binds to filensin intermediate filaments [PDF]

FEBS Letters, 2003
Tropomodulin (Tmod) is an actin filament pointed end capping protein found in the membrane skeleton of lens fiber cells. We demonstrate that Tmod4 is able to bind the lens‐specific intermediate filament protein, filensin, in either co‐sedimentation or solid phase binding assays in a saturable fashion, but with low affinity and stoichiometry ...
Fischer, R.S., Quinlan, R.A., Fowler, V.M.   +2 more
openaire   +2 more sources

Tropomodulin 3 Binds to Actin Monomers [PDF]

Journal of Biological Chemistry, 2006
Regulation of the actin cytoskeleton by filament capping proteins is critical to myriad dynamic cellular functions. The ability of these proteins to bind both filaments as well as monomers is often central to their cellular functions. The ubiquitous pointed end capping protein Tmod3 (tropomodulin 3) acts as a negative regulator of cell migration, yet ...
Robert S, Fischer, Elena G, Yarmola, Kari L, Weber, Kaye D, Speicher, David W, Speicher, Michael R, Bubb, Velia M, Fowler   +6 more
openaire   +2 more sources

Tropomodulins are negative regulators of neurite outgrowth [PDF]

European Journal of Cell Biology, 2011
Regulation of the actin cytoskeleton is critical for neurite formation. Tropomodulins (Tmods) regulate polymerization at actin filament pointed ends. Previous experiments using a mouse model deficient for the neuron specific isoform Tmod2 suggested a role for Tmods in neuronal function by impacting processes underlying learning and memory. However, the
Fath, T., Fischer, R., Dehmelt, L., Halpain, S., Fowler, V.   +4 more
openaire   +3 more sources

Tropomodulin binding to tropomyosins [PDF]

European Journal of Biochemistry, 1992
Tropomodulin is a human erythrocyte membrane cytoskeletal protein that binds to one end of tropomyosin molecules and inhibits tropomyosin binding to actin filaments [Fowler, V. M. (1990) J. Cell Biol. 111, 471–482]. We have characterized the interaction of erythroid and non‐erythroid tropomyosins with tropomodulin by non‐denaturing gel electrophoresis ...
M A, Sussman, V M, Fowler
openaire   +2 more sources

Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling

Journal of Experimental & Clinical Cancer Research, 2022
Background Abnormal proliferation and migration of cells are hallmarks of cancer initiation and malignancy. Asparagine endopeptidase (AEP) has specific substrate cleavage ability and plays a pro-cancer role in a variety of cancers.
Binghong Chen, Mengying Wang, Junjun Qiu, Keman Liao, Wenrui Zhang, Qi Lv, Chunhui Ma, Zhongrun Qian, Zhonggang Shi, Rong Liang, Yan Lin, Jiazhou Ye, Yongming Qiu, Yingying Lin   +13 more
doaj   +1 more source

Titin Isoform Size is Not Correlated with Thin Filament Length in Rat Skeletal Muscle

Frontiers in Physiology, 2014
The mechanisms controlling thin filament length in muscle remain controversial. It was recently reported that thin filament length was related to titin size, and that the latter might be involved in thin filament length determination.
Marion Lewis Greaser, Jonathan M Pleitner   +1 more
doaj   +1 more source

Cerebrospinal fluid proteins in relation to longitudinal cognitive trajectories. [PDF]

Alzheimers Dement
Abstract INTRODUCTION We investigated longitudinal cognitive trajectories in relation to cerebrospinal fluid (CSF) proteomics in Alzheimer's disease (AD). METHODS Differential protein abundance analysis of proteomics (SomaScan 7K) data was performed for composite scores for domain‐specific cognitive functions (memory [MEM], executive function [EF], and
Kim BH, Seo SW, Kim J, Nho K, Alzheimer's Disease Neuroimaging Initiative#.   +4 more
europepmc   +2 more sources

Fluid Shear Stress Upregulates E-Tmod41 via miR-23b-3p and Contributes to F-Actin Cytoskeleton Remodeling during Erythropoiesis. [PDF]

PLoS ONE, 2015
The membrane skeleton of mature erythrocyte is formed during erythroid differentiation. Fluid shear stress is one of the main factors that promote embryonic hematopoiesis, however, its effects on erythroid differentiation and cytoskeleton remodeling are ...
Weiyun Mu, Xifu Wang, Xiaolan Zhang, Sida Zhu, Dagong Sun, Weibo Ka, Lanping Amy Sung, Weijuan Yao   +7 more
doaj   +1 more source

unc-94 Encodes a Tropomodulin in Caenorhabditis elegans [PDF]

Journal of Molecular Biology, 2007
unc-94 is one of about 40 genes in Caenorhabditis elegans that, when mutant, displays an abnormal muscle phenotype. Two mutant alleles of unc-94, su177 and sf20, show reduced motility and brood size and disorganization of muscle structure. In unc-94 mutants, immunofluorescence microscopy shows that a number of known sarcomeric proteins are abnormal ...
Tesheka O, Stevenson, Kristina B, Mercer, Elisabeth A, Cox, Nathaniel J, Szewczyk, Catharine A, Conley, Jeffrey D, Hardin, Guy M, Benian   +6 more
openaire   +2 more sources