Results 31 to 40 of about 2,101 (172)

Cerebrospinal fluid proteins in relation to longitudinal cognitive trajectories. [PDF]

Alzheimers Dement
Abstract INTRODUCTION We investigated longitudinal cognitive trajectories in relation to cerebrospinal fluid (CSF) proteomics in Alzheimer's disease (AD). METHODS Differential protein abundance analysis of proteomics (SomaScan 7K) data was performed for composite scores for domain‐specific cognitive functions (memory [MEM], executive function [EF], and
Kim BH, Seo SW, Kim J, Nho K, Alzheimer's Disease Neuroimaging Initiative#.   +4 more
europepmc   +2 more sources

Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts

Frontiers in Endocrinology, 2021
Insulin and muscle contractions mediate glucose transporter 4 (GLUT4) translocation and insertion into the plasma membrane (PM) for glucose uptake in skeletal muscles.
Man Mohan Shrestha, Chun-Yan Lim, Xuezhi Bi, Robert C. Robinson, Weiping Han, Weiping Han   +5 more
doaj   +1 more source

Effect of Chitosan Composite Preservative on Proteome Changes of Grass Carp Muscle during Cold Storage [PDF]

Shipin Kexue, 2023
To explore the effect of a chitosan-based preservative solution (10 mg/mL chitosan + 5 mg/mL tea polyphenol + 2 000 U/mL lysozyme) on the change in the muscle proteome of grass carp during cold storage, differential proteomic analysis of fresh fish and ...
LI Jialei, CHEN Sai, TIAN Mingli, YU Jian, LIU Yongle, WANG Faxiang
doaj   +1 more source

Tropomodulin 3 Binds to Actin Monomers [PDF]

Journal of Biological Chemistry, 2006
Regulation of the actin cytoskeleton by filament capping proteins is critical to myriad dynamic cellular functions. The ability of these proteins to bind both filaments as well as monomers is often central to their cellular functions. The ubiquitous pointed end capping protein Tmod3 (tropomodulin 3) acts as a negative regulator of cell migration, yet ...
Robert S, Fischer, Elena G, Yarmola, Kari L, Weber, Kaye D, Speicher, David W, Speicher, Michael R, Bubb, Velia M, Fowler   +6 more
openaire   +2 more sources

Favorable prognostic role of tropomodulins in neuroblastoma [PDF]

Oncotarget, 2018
Neuroblastoma is a pediatric tumor of the sympatoadrenal lineage of the neural crest characterized by high molecular and clinical heterogeneity, which are the main causes of the poor response to standard multimodal therapy. The identification of new and selective biomarkers is important to improve our knowledge on the mechanisms of neuroblastoma ...
Bettinsoli P, Ferrari-Toninelli G, Bonini SA, Guarienti M, Cangelosi D, Varesio L, Memo M   +6 more
openaire   +3 more sources

Tropomodulin binding to tropomyosins [PDF]

European Journal of Biochemistry, 1992
Tropomodulin is a human erythrocyte membrane cytoskeletal protein that binds to one end of tropomyosin molecules and inhibits tropomyosin binding to actin filaments [Fowler, V. M. (1990) J. Cell Biol. 111, 471–482]. We have characterized the interaction of erythroid and non‐erythroid tropomyosins with tropomodulin by non‐denaturing gel electrophoresis ...
M A, Sussman, V M, Fowler
openaire   +2 more sources

Tropomodulins are negative regulators of neurite outgrowth [PDF]

European Journal of Cell Biology, 2011
Regulation of the actin cytoskeleton is critical for neurite formation. Tropomodulins (Tmods) regulate polymerization at actin filament pointed ends. Previous experiments using a mouse model deficient for the neuron specific isoform Tmod2 suggested a role for Tmods in neuronal function by impacting processes underlying learning and memory. However, the
Fath, T., Fischer, R., Dehmelt, L., Halpain, S., Fowler, V.   +4 more
openaire   +3 more sources

1H1815 Tropomodulin domain structure

Seibutsu Butsuri, 2000
Kostyukova, Alla, Tiktopulo, Elizaveta, Krieger, Inna, Maeda, K., Maeda, Y.   +4 more
openaire   +3 more sources

Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling

Journal of Experimental & Clinical Cancer Research, 2022
Background Abnormal proliferation and migration of cells are hallmarks of cancer initiation and malignancy. Asparagine endopeptidase (AEP) has specific substrate cleavage ability and plays a pro-cancer role in a variety of cancers.
Binghong Chen, Mengying Wang, Junjun Qiu, Keman Liao, Wenrui Zhang, Qi Lv, Chunhui Ma, Zhongrun Qian, Zhonggang Shi, Rong Liang, Yan Lin, Jiazhou Ye, Yongming Qiu, Yingying Lin   +13 more
doaj   +1 more source

Fluid Shear Stress Upregulates E-Tmod41 via miR-23b-3p and Contributes to F-Actin Cytoskeleton Remodeling during Erythropoiesis. [PDF]

PLoS ONE, 2015
The membrane skeleton of mature erythrocyte is formed during erythroid differentiation. Fluid shear stress is one of the main factors that promote embryonic hematopoiesis, however, its effects on erythroid differentiation and cytoskeleton remodeling are ...
Weiyun Mu, Xifu Wang, Xiaolan Zhang, Sida Zhu, Dagong Sun, Weibo Ka, Lanping Amy Sung, Weijuan Yao   +7 more
doaj   +1 more source