Results 51 to 60 of about 2,192 (170)
PLoS Genetics, 2014 During muscle development, myosin and actin containing filaments assemble into the highly organized sarcomeric structure critical for muscle function.
Imre Molnár +14 more
doaj +1 more source
Mechanism of actin filament pointed-end capping by tropomodulin [PDF]
Science, 2014 Making tropomodulin find the right point Actin filaments are a key component of the cell's cytoskeleton. Actin filaments have a characteristic polarized architecture with a so-called barbed end and a pointed end—so described because of how the filaments look under the electron microscope when they are coated with tropomyosin. Rao
Jampani Nageswara, Rao +2 more
openaire +2 more sources
Effect of the Structure of the N Terminus of Tropomyosin on Tropomodulin Function [PDF]
Journal of Biological Chemistry, 2004 Tropomodulins (Tmod) bind to the N terminus of tropomyosin and cap the pointed end of actin filaments. Tropomyosin alone also inhibits the rate of actin depolymerization at the pointed end of filaments. Here we have defined 1) the structural requirements of the N terminus of tropomyosin important for regulating the pointed end alone and with ...
Kostyukova, Alla S +1 more
openaire +3 more sources
Molecular characterisation of a tropomodulin- homologue from E. multilocularis
, 2002 Zusammenfassend konnte im Rahmen dieser Arbeit erstmals ein Tropomodulin- homologer Faktor aus einem Plathelminthen auf molekularer Ebene charakterisiert werden. Zudem wurde die Interaktion des kodierten Faktors mit einem kürzlich isolierten Tropomyosin-
Beland, Heidi
core +2 more sources
The erythrocyte skeletons of β-adducin deficient mice have altered levels of tropomyosin, tropomodulin and EcapZ [PDF]
, 2004 The erythrocyte membrane cytoskeleton is organized as a polygonal spectrin network linked to short actin filaments that are capped by adducin at the barbed ends. We have constructed a mouse strain deficient in β-adducin having abnormal erythrocytes.
Baralle, Francisco E. +4 more
core +1 more source
Disease Models & Mechanisms, 2014 Nemaline myopathy is an inherited muscle disease that is mainly diagnosed by the presence of nemaline rods in muscle biopsies. Of the nine genes associated with the disease, five encode components of striated muscle sarcomeres.
Joachim Berger +6 more
doaj +1 more source
Actin Filament Pointed Ends: Assays for Regulation of Assembly and Disassembly by Tropomodulin and Tropomyosin. [PDF]
Cytoskeleton (Hoboken)ABSTRACT Actin filaments are dynamic polymers whose length depends on regulated monomer association and dissociation at their ends. Actin barbed‐end dynamics are relatively better understood, primarily due to the approximately tenfold faster subunit on/off rates at barbed versus pointed ends.
Yamashiro S +5 more
europepmc +2 more sources
Assembly and Maintenance of Myofibrils in the Heart
Cytoskeleton, EarlyView.ABSTRACT The assembly of actin and myosin to the paracrystalline arrangement of myofibrils in striated muscle, that is, heart and skeletal, has puzzled many a cell biologist. Different models, based on cultured cardiomyocytes, were proposed for the last 30 years to explain the sequence of events.
Elisabeth Ehler
wiley +1 more source
Cytoplasmic Nuclear Transfer of the Actin-capping Protein Tropomodulin [PDF]
Journal of Biological Chemistry, 2004 Tropomodulin (Tmod) is a cytoskeletal actin-capping protein that interacts with tropomyosin at the pointed end of actin filaments. E-Tmod is an isoform that expresses predominantly in cardiac cells and slow skeletal muscle fibers. We unexpectedly discovered significant levels of Tmod in nuclei and then defined peptide domains in Tmod responsible for ...
Kimi Y, Kong, Larry, Kedes
openaire +2 more sources