Actin Filament Pointed Ends: Assays for Regulation of Assembly and Disassembly by Tropomodulin and Tropomyosin. [PDF]
Cytoskeleton (Hoboken)ABSTRACT Actin filaments are dynamic polymers whose length depends on regulated monomer association and dissociation at their ends. Actin barbed‐end dynamics are relatively better understood, primarily due to the approximately tenfold faster subunit on/off rates at barbed versus pointed ends.
Yamashiro S +5 more
europepmc +2 more sources
Hematopoietic protein-1 regulates the actin membrane skeleton and membrane stability in murine erythrocytes. [PDF]
PLoS ONE, 2013 Hematopoietic protein-1 (Hem-1) is a hematopoietic cell specific member of the WAVE (Wiskott-Aldrich syndrome verprolin-homologous protein) complex, which regulates filamentous actin (F-actin) polymerization in many cell types including immune cells ...
Maia M Chan +10 more
doaj +1 more source
unc-94 Encodes a Tropomodulin in Caenorhabditis elegans [PDF]
Journal of Molecular Biology, 2007 unc-94 is one of about 40 genes in Caenorhabditis elegans that, when mutant, displays an abnormal muscle phenotype. Two mutant alleles of unc-94, su177 and sf20, show reduced motility and brood size and disorganization of muscle structure. In unc-94 mutants, immunofluorescence microscopy shows that a number of known sarcomeric proteins are abnormal ...
Tesheka O, Stevenson +6 more
openaire +2 more sources
Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle. [PDF]
Journal of Biological Chemistry, 1999 Tropomodulin (E-Tmod) is an actin filament pointed end capping protein that maintains the length of the sarcomeric actin filaments in striated muscle. Here, we describe the identification and characterization of a novel tropomodulin isoform, skeletal tropomodulin (Sk-Tmod) from chickens. Sk-Tmod is 62% identical in amino acid sequence to the previously
A, Almenar-Queralt +4 more
openaire +2 more sources
Alterations in thin filament length during postnatal skeletal muscle development and aging in mice
Frontiers in Physiology, 2014 The lengths of the sarcomeric thin filaments vary in a skeletal muscle-specific manner and help specify the physiological properties of skeletal muscle.
David S Gokhin +4 more
doaj +1 more source
Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia [PDF]
, 2021 The molecular mechanisms leading to high-altitude pulmonary hypertension (HAPH) remains poorly understood. We previously analyzed the whole genome sequence of Kyrgyz highland population and identified eight genomic intervals having a potential role in ...
Haddad, Gabriel G +5 more
core +1 more source
Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens. [PDF]
PLoS ONE, 2012 The basis for mammalian lens fiber cell organization, transparency, and biomechanical properties has contributions from two specialized cytoskeletal systems: the spectrin-actin membrane skeleton and beaded filament cytoskeleton.
David S Gokhin +7 more
doaj +1 more source
Surgical treatment and muscle protein analysis of V-pattern exotropia in craniosynostosis
Scientific Reports, 2022 The purpose of this study was to compare the differences of V-pattern exotropia in craniosynostosis and normal children. 39 children were included in this study, 19 craniosynostosis and 20 children in control group.
Qingyu Liu +6 more
doaj +1 more source
PLoS Genetics, 2014 During muscle development, myosin and actin containing filaments assemble into the highly organized sarcomeric structure critical for muscle function.
Imre Molnár +14 more
doaj +1 more source