Crystal Structure of the C-Terminal Half of Tropomodulin and Structural Basis of Actin Filament Pointed-End Capping [PDF]
, 2002 Tropomodulin is the unique pointed-end capping protein of the actin-tropomyosin filament. By blocking elongation and depolymerization, tropomodulin regulates the architecture and the dynamics of the filament.
Yamashita, Atsuko +4 more
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Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle. [PDF]
Journal of Biological Chemistry, 1999 Tropomodulin (E-Tmod) is an actin filament pointed end capping protein that maintains the length of the sarcomeric actin filaments in striated muscle. Here, we describe the identification and characterization of a novel tropomodulin isoform, skeletal tropomodulin (Sk-Tmod) from chickens. Sk-Tmod is 62% identical in amino acid sequence to the previously
A, Almenar-Queralt +4 more
openaire +2 more sources
Hematopoietic protein-1 regulates the actin membrane skeleton and membrane stability in murine erythrocytes. [PDF]
PLoS ONE, 2013 Hematopoietic protein-1 (Hem-1) is a hematopoietic cell specific member of the WAVE (Wiskott-Aldrich syndrome verprolin-homologous protein) complex, which regulates filamentous actin (F-actin) polymerization in many cell types including immune cells ...
Maia M Chan +10 more
doaj +1 more source
Alterations in thin filament length during postnatal skeletal muscle development and aging in mice
Frontiers in Physiology, 2014 The lengths of the sarcomeric thin filaments vary in a skeletal muscle-specific manner and help specify the physiological properties of skeletal muscle.
David S Gokhin +4 more
doaj +1 more source
The shapes and sizes of two domains of tropomodulin, the P-end-capping protein of actin-tropomyosin [PDF]
, 2001 Tropomodulin, the P-end (slow-growing end)-capping protein of the actin-tropomyosin filament, and its fragment (C20) of the C-terminal half were studied by synchrotron small-angle X-ray scattering, restoring low-resolution shapes using an ab initio shape-
Tetsuro Fujisawa +5 more
core +1 more source
Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens. [PDF]
PLoS ONE, 2012 The basis for mammalian lens fiber cell organization, transparency, and biomechanical properties has contributions from two specialized cytoskeletal systems: the spectrin-actin membrane skeleton and beaded filament cytoskeleton.
David S Gokhin +7 more
doaj +1 more source
Multifunctional roles of tropomodulin-3 in regulating actin dynamics [PDF]
Biophysical Reviews, 2018 Tropomodulins (Tmods) are proteins that cap the slow growing (pointed) ends of actin filaments (F-actin). The basis for our current understanding of Tmod function comes from studies in cells with relatively stable and highly organized F-actin networks, leading to the view that Tmod capping functions principally to preserve F-actin stability.
Parreno, Justin, Fowler, Velia M
openaire +2 more sources
Surgical treatment and muscle protein analysis of V-pattern exotropia in craniosynostosis
Scientific Reports, 2022 The purpose of this study was to compare the differences of V-pattern exotropia in craniosynostosis and normal children. 39 children were included in this study, 19 craniosynostosis and 20 children in control group.
Qingyu Liu +6 more
doaj +1 more source
Structure and Tropomyosin Binding Properties of the N-Terminal Capping Domain of Tropomodulin 1 [PDF]
, 2005 Two families of actin regulatory proteins are the tropomodulins and tropomyosins. Tropomodulin binds to tropomyosin (TM) and to the pointed end of actin filaments and “caps” the pointed end (i.e., inhibits its polymerization and depolymerization ...
Kostyukova, Alla S +5 more
core +1 more source
Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia [PDF]
, 2021 The molecular mechanisms leading to high-altitude pulmonary hypertension (HAPH) remains poorly understood. We previously analyzed the whole genome sequence of Kyrgyz highland population and identified eight genomic intervals having a potential role in ...
Haddad, Gabriel G +5 more
core +1 more source