Results 71 to 80 of about 2,101 (172)

Structure and Tropomyosin Binding Properties of the N-Terminal Capping Domain of Tropomodulin 1

, 2005
Two families of actin regulatory proteins are the tropomodulins and tropomyosins. Tropomodulin binds to tropomyosin (TM) and to the pointed end of actin filaments and “caps” the pointed end (i.e., inhibits its polymerization and depolymerization ...
Kostyukova, Alla S, Kostyukova, Alla S., Greenfield, Norma J, Hitchcock-DeGregori, Sarah E., Hitchcock-DeGregori, Sarah E, Greenfield, Norma J.   +5 more
core   +1 more source

Tropomodulins and Leiomodins: Actin Pointed End Caps and Nucleators in Muscles [PDF]

Biophysical Journal, 2017
Cytoskeletal structures characterized by actin filaments with uniform lengths, including the thin filaments of striated muscles and the spectrin-based membrane skeleton, use barbed and pointed-end capping proteins to control subunit addition/dissociation at filament ends.
Velia M, Fowler, Roberto, Dominguez
openaire   +2 more sources

The transcriptional profile of iron deficiency in patients with heart failure: Heme‐sparing and reduced immune processes

European Journal of Heart Failure, Volume 27, Issue 11, Page 2313-2324, November 2025.
The analysis workflow, findings and potential clinical consequences of iron deficiency in heart failure (HF). From 881 patients with worsening HF, whole blood transcriptome was analysed using the Affymetrix Human Transcriptome Array (HTA) 2.0. Subjects were stratified according to their transferrin saturation (TSAT) levels as iron‐deficient (TSAT <20%)
Niels Grote Beverborg, Ridha I.S. Alnuwaysir, George Markousis‐Mavrogenis, Martijn F. Hoes, Haye H. van der Wal, Simon P.R. Romaine, Mintu Nath, Andrea Koekoemoer, John G.F. Cleland, Chim C. Lang, Stefan D. Anker, Kenneth Dickstein, Marco Metra, Leong L. Ng, Dirk J. van Veldhuisen, Adriaan A. Voors, Nilesh J. Samani, Peter van der Meer   +17 more
wiley   +1 more source

Super‐Resolution Microscopy in Tissue Engineering

Advanced Materials Interfaces, Volume 12, Issue 19, October 6, 2025.
Super‐resolution microscopy (SRM) has advanced tissue engineering by providing nanoscale insights into cellular interactions. It reveals detailed cell membrane structures, tracks vesicle and virus entry, and visualizes the cytoskeleton. SRM also improves understanding of cell migration, facilitating tissue regeneration, vascularization, immune ...
Navid Rabiee, Mohammad Akrami‐Hasan‐Kohal, Sidi A. Bencherif   +2 more
wiley   +1 more source

Tropomodulin caps the pointed ends of actin filaments. [PDF]

The Journal of cell biology, 1994
Many proteins have been shown to cap the fast growing (barbed) ends of actin filaments, but none have been shown to block elongation and depolymerization at the slow growing (pointed) filament ends. Tropomodulin is a tropomyosin-binding protein originally isolated from red blood cells that has been localized by immunofluorescence staining to a site at ...
A, Weber, C R, Pennise, G G, Babcock, V M, Fowler   +3 more
openaire   +2 more sources

Cardiac-Specific IGF-1 Expression Attenuates Dilated Cardiomyopathy in Tropomodulin-Overexpressing Transgenic Mice

, 2002
To test the hypothesis that early interventional treatment with insulin-like growth factor-1 (IGF-1) alleviates subsequent development of dilated cardiomyopathy, cardiac-specific IGF-1 expression was introduced by selective cross-breeding into a ...
Sandra Witt, Anna Maria Andreoli, Annarosa Leri, Sara Welch, Betty Glascock, Piero Anversa, Jan Kajstura, David Plank, Federica Limana, Erik Schaefer, Mark A. Sussman, Stefano Chimenti   +11 more
core   +1 more source

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang, Yujie Shan, Shihong Xu, Jing Wang, Meng Luo, Jiaojiao Zhou, Qishan Chen   +6 more
wiley   +1 more source

Role of Tropomodulins in brain physiology and pathology

Neurobiology of Disease
Actin dynamics are crucial for the morphogenesis and function of neurons in the brain. Tropomodulins (Tmods) belong to a family of actin-binding proteins that cap the pointed-end of actin filaments. There are four Tmod isoforms, and three of which, Tmod1, Tmod2 and Tmod3, are expressed in the brain, with Tmod2 exhibiting neuronal specific expression ...
Chuan Hong, Xiaopeng Liu, Zhou Zhou, Yuan Xing, Zixuan Cao, Yan-Zhong Chang, Guofen Gao   +6 more
openaire   +3 more sources

Myofibrillogenesis in the developing chicken heart: role of actin isoforms and of the pointed end actin capping protein tropomodulin during thin filament assembly

, 2004
Recently, important differences between myofibrillogenesis in cultured cardiomyocytes vs. the three-dimensional setting in situ could be determined. We investigated thin filament assembly in situ by confocal microscopy of whole-mount preparations of ...
Ehler, E, Perriard, J C, Fowler, V M
core   +1 more source

The erythrocyte skeletons of β-adducin deficient mice have altered levels of tropomyosin, tropomodulin and EcapZ

, 2004
The erythrocyte membrane cytoskeleton is organized as a polygonal spectrin network linked to short actin filaments that are capped by adducin at the barbed ends. We have constructed a mouse strain deficient in β-adducin having abnormal erythrocytes.
Baralle, Francisco E., Muro, Andrés F., Marro, Martı́n L., Porro, Fabiola, Costessi, Luisa   +4 more
core   +1 more source