Results 91 to 100 of about 2,192 (170)

The Actin‐Binding Prolyl‐Isomerase Par17 Sustains Its Substrate Selectivity by Interdomain Allostery

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 9, Page 1481-1497, September 2025.
ABSTRACT The human peptidyl‐prolyl‐cis/trans isomerases (PPIases), Parvulin 14 and Parvulin 17, accelerate the cis/trans isomerization of Xaa‐Pro moieties within protein sequences. By modulating the respective binding interfaces of their target proteins, they play a crucial role in determining the fate of their substrates within the cell. Although both
Anna Sternberg, Jennifer Lynne Borger, Mathilda Thies, Anja Matena, Mike Blueggel, Bianca E. Kamba, Christine Beuck, Farnusch Kaschani, Markus Kaiser, Peter Bayer   +9 more
wiley   +1 more source

Recessive TMOD1 mutation causes childhood cardiomyopathy

Communications Biology
Familial cardiomyopathy in pediatric stages is a poorly understood presentation of heart disease in children that is attributed to pathogenic mutations. Through exome sequencing, we report a homozygous variant in tropomodulin 1 (TMOD1; c.565C>T, p.R189W)
Catalina Vasilescu, Mert Colpan, Tiina H. Ojala, Tuula Manninen, Aino Mutka, Kaisa Ylänen, Otto Rahkonen, Tuija Poutanen, Laura Martelius, Reena Kumari, Helena Hinterding, Virginia Brilhante, Simo Ojanen, Pekka Lappalainen, Juha Koskenvuo, Christopher J. Carroll, Velia M. Fowler, Carol C. Gregorio, Anu Suomalainen   +18 more
doaj   +1 more source

Leiomodins: Larger Members of the Tropomodulin (Tmod) Gene Family

Genomics, 2001
The 64-kDa autoantigen D1 or 1D, first identified as a potential autoantigen in Graves' disease, is similar to the tropomodulin (Tmod) family of actin filament pointed end-capping proteins. A novel gene with significant similarity to the 64-kDa human autoantigen D1 has been cloned from both humans and mice, and the genomic sequences of both genes have ...
C A, Conley, K L, Fritz-Six, A, Almenar-Queralt, V M, Fowler   +3 more
openaire   +2 more sources

Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers

, 2014
In skeletal muscle, thick and thin filaments are arranged in a myofibrillar lattice. Tropomodulin 1 (Tmod1) is a pointed-end capping and tropomyosin-binding protein that controls thin-filament assembly, stability, and lengths.
Ochala, Julien; id_orcid, Iwamoto, Hiroyuki, Fowler, Velia M, Gokhin, David S   +3 more
core   +1 more source

M6A-modified BFSP1 induces aerobic glycolysis to promote liver cancer growth and metastasis through upregulating tropomodulin 4

Molecular Biomedicine
RNA N6-methyladenosine (m6A) is a common RNA modification in eukaryotes, and its abnormal regulation is closely related to cancer progression. Aerobic glycolysis is a main way for cancer cells to obtain energy.
Rong Li, Shunle Li, Lin Shen, Junhui Li, Di Zhang, Jinmin Yu, Lanxuan Huang, Na Liu, Hongwei Lu, Meng Xu   +9 more
doaj   +1 more source

Different Localizations and Cellular Behaviors of Leiomodin and Tropomodulin in Mature Cardiomyocyte Sarcomeres

, 2010
Leiomodin (Lmod) is a muscle-specific F-actin–nucleating protein that is related to the F-actin pointed-end–capping protein tropomodulin (Tmod). However, Lmod contains a unique ∼150-residue C-terminal extension that is required for its strong nucleating
Malgorzata Boczkowska, Aneta Skwarek-Maruszewska, Elena Kremneva, Pekka Lappalainen, Tatyana Svitkina, Allison L. Zajac, Roberto Dominguez   +6 more
core   +1 more source

Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle [PDF]

, 2020
Duchenne muscular dystrophy (DMD) induces sarcolemmal mechanical instability and rupture, hyperactivity of intracellular calpains, and proteolytic breakdown of muscle structural proteins.
Velia M Fowler, Matthew T Tierney, Zhenhua Sui, David S Gokhin, Alessandra Sacco   +4 more
core  

Systematic analysis of tropomodulin/tropomyosin interactions uncovers fine-tuned binding specificity of intrinsically disordered proteins

, 2011
An intriguing regulatory mechanism is the ability of some proteins to recognize their binding partners in an isoform-specific manner. In this study we undertook a systematic analysis of the specificity of the tropomodulin (Tmod) interaction with ...
Kostyukova, Alla S., Uversky, Vladimir N., Gritsyna, Yulia, Samar P. Shah, Sarah E. Hitchcock-DeGregori, Hitchcock-DeGregori, Sarah E., Yulia Gritsyna, Alla S. Kostyukova, Vladimir N. Uversky, Shah, Samar P.   +9 more
core   +1 more source

Intra-amniotic delivery of tropomodulin 3 rescues cell apoptosis induced by miR-200b-3p upregulation via non-canonical nuclear factor kappa B pathways in ethylene thiourea induced anorectal malformations fetal rat

Ecotoxicology and Environmental Safety
Ethylene thiourea (ETU), a metabolite of the fungicide ethylene bisdithiocarbamate (EBDC), has received great concern because of its harmful effects. ETU-induced anorectal malformations (ARMs) in rat models have been reported and widely used in the study
Peiqi Liu, Yue Li, Yifan Yao, Weilin Wang, Huimin Jia, Yuzuo Bai, Zhengwei Yuan, Zhonghua Yang   +7 more
doaj   +1 more source

The interaction between E-tropomodulin and thymosin β-10 rescues tumor cells from thymosin β-10 mediated apoptosis by restoring actin architecture [PDF]

, 2004
Thymosin β-10 (TB10) is a small G-actin binding protein that induces depolymerization of intracellular F-actin pools by sequestering actin monomers. Previously, we demonstrated that overexpression of TB10 in ovarian tumor cells increased the rate of cell
Seung-Hoon Lee, Kyoungsook Park, Je-Ho Lee, Taehoon Chun, Chun, Taehoon, Lee, Je-Ho, Rho, Seung Bae, Lee, Seung-Hoon, Park, Kyoungsook, Seung Bae Rho   +9 more
core   +1 more source