Results 91 to 100 of about 2,101 (172)

Molecular characterisation of a tropomodulin- homologue from E. multilocularis

, 2002
Zusammenfassend konnte im Rahmen dieser Arbeit erstmals ein Tropomodulin- homologer Faktor aus einem Plathelminthen auf molekularer Ebene charakterisiert werden. Zudem wurde die Interaktion des kodierten Faktors mit einem kürzlich isolierten Tropomyosin-
Beland, Heidi
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Different Localizations and Cellular Behaviors of Leiomodin and Tropomodulin in Mature Cardiomyocyte Sarcomeres

, 2010
Leiomodin (Lmod) is a muscle-specific F-actin–nucleating protein that is related to the F-actin pointed-end–capping protein tropomodulin (Tmod). However, Lmod contains a unique ∼150-residue C-terminal extension that is required for its strong nucleating
Malgorzata Boczkowska, Aneta Skwarek-Maruszewska, Elena Kremneva, Pekka Lappalainen, Tatyana Svitkina, Allison L. Zajac, Roberto Dominguez   +6 more
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Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle [PDF]

, 2020
Duchenne muscular dystrophy (DMD) induces sarcolemmal mechanical instability and rupture, hyperactivity of intracellular calpains, and proteolytic breakdown of muscle structural proteins.
Velia M Fowler, Matthew T Tierney, Zhenhua Sui, David S Gokhin, Alessandra Sacco   +4 more
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Tropomodulin Protects α-Catenin-Dependent Junctional-Actin Networks under Stress during Epithelial Morphogenesis

, 2012
Summaryα-catenin is central to recruitment of actin networks to the cadherin-catenin complex [1, 2], but how such networks are subsequently stabilized against stress applied during morphogenesis is poorly understood.
Lynch, Allison M., Eno, Celeste C., Zaidel-Bar, Ronen, Walck-Shannon, Elise, Yamashiro, Sawako, Hardin, Jeff, Cox-Paulson, Elisabeth A., Ono, Shoichiro   +7 more
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Tropomodulin 1 Regulation of Actin Is Required for the Formation of Large Paddle Protrusions Between Mature Lens Fiber CellsTmod1 and Lens Fiber Cell Interdigitations [PDF]

, 2016
PurposeTo elucidate the proteins required for specialized small interlocking protrusions and large paddle domains at lens fiber cell tricellular junctions (vertices), we developed a novel method to immunostain single lens fibers and studied changes in ...
Lo, Woo-Kuen, FitzGerald, Paul G, Cheng, Catherine, Nowak, Roberta B, Biswas, Sondip K, Fowler, Velia M   +5 more
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Systematic analysis of tropomodulin/tropomyosin interactions uncovers fine-tuned binding specificity of intrinsically disordered proteins

, 2011
An intriguing regulatory mechanism is the ability of some proteins to recognize their binding partners in an isoform-specific manner. In this study we undertook a systematic analysis of the specificity of the tropomodulin (Tmod) interaction with ...
Kostyukova, Alla S., Uversky, Vladimir N., Gritsyna, Yulia, Samar P. Shah, Sarah E. Hitchcock-DeGregori, Hitchcock-DeGregori, Sarah E., Yulia Gritsyna, Alla S. Kostyukova, Vladimir N. Uversky, Shah, Samar P.   +9 more
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Intra-amniotic delivery of tropomodulin 3 rescues cell apoptosis induced by miR-200b-3p upregulation via non-canonical nuclear factor kappa B pathways in ethylene thiourea induced anorectal malformations fetal rat

Ecotoxicology and Environmental Safety
Ethylene thiourea (ETU), a metabolite of the fungicide ethylene bisdithiocarbamate (EBDC), has received great concern because of its harmful effects. ETU-induced anorectal malformations (ARMs) in rat models have been reported and widely used in the study
Peiqi Liu, Yue Li, Yifan Yao, Weilin Wang, Huimin Jia, Yuzuo Bai, Zhengwei Yuan, Zhonghua Yang   +7 more
doaj   +1 more source

Molecular basis of tropomyosin binding to tropomodulin, an actin-capping protein

, 2007
The tropomodulin (Tmod) family of proteins that cap the pointed, slow-growing end of actin filaments require tropomyosin (TM) for optimal function. Earlier studies identified two regions in Tmod1 that bind the N terminus of TM, though the ability of ...
Kostyukova, Alla S, Greenfield, Norma J, Hitchcock-Degregori, Sarah E   +2 more
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The interaction between E-tropomodulin and thymosin β-10 rescues tumor cells from thymosin β-10 mediated apoptosis by restoring actin architecture

, 2004
Thymosin β-10 (TB10) is a small G-actin binding protein that induces depolymerization of intracellular F-actin pools by sequestering actin monomers. Previously, we demonstrated that overexpression of TB10 in ovarian tumor cells increased the rate of cell
Seung-Hoon Lee, Kyoungsook Park, Je-Ho Lee, Taehoon Chun, Chun, Taehoon, Lee, Je-Ho, Rho, Seung Bae, Lee, Seung-Hoon, Park, Kyoungsook, Seung Bae Rho   +9 more
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Role of erythrocyte tropomodulin in the biomechanics and topology of the erythrocyte membrane skeletal network [PDF]

, 2010
The erythrocyte membrane skeleton is a multi-protein complex providing mechanical properties and stability to erythrocytes. Defects in the skeleton can manifest in dysfunction and disease such as hemolytic anemia.
Green, Terrell Ann
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