Results 21 to 30 of about 44,311 (250)

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

Cell Reports, 2017
Striated muscle contraction is regulated by the movement of tropomyosin over the thin filament surface, which blocks or exposes myosin binding sites on actin.
Meera C. Viswanathan, William Schmidt, Michael J. Rynkiewicz, Karuna Agarwal, Jian Gao, Joseph Katz, William Lehman, Anthony Cammarato   +7 more
doaj   +1 more source

Gene Cloning and Prokaryotic Expression of the Allergen Tropomyosin from Macrobrachium nipponense [PDF]

Shipin Kexue
To explore substitutes for natural tropomyosin as basic materials for the diagnosis and treatment of shrimp allergy, total RNA was extracted from Macrobrachium nipponense, and the full-length sequence of the tropomyosin gene was cloned by rapid ...
LUO Yeqing, ZHENG Shuangyan, SUN Yaobin, CHEN Jiao, LIU Xin, CHEN Hongbing, XIE Yanhai
doaj   +1 more source

Digestion of tropomyosin with trypsin [PDF]

FEBS Letters, 1977
Tropomyosin is a rod-like a-helical protein composed of two similar subunits in a coiled-coil configuration. It is situated in the grooves of the F-actin strands and with troponin constitutes the regulatory-complex of vertebrate striated muscle. The sequence of the tropomyosin subunit has been determined by Stone, et al. [ 11.
Gorecka, A., Drabikowski, W.
openaire   +2 more sources

A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics [PDF]

, 2016
The tropomyosin family of proteins form end-to-end polymers along the actin filament. Tumour cells rely on specific tropomyosin-containing actin filament populations for growth and survival.
Böcking, T ; https://orcid.org/, Stehn, JR ; https://orcid.org/, Byun, A, Janco, M ; https://orcid.org/, Bonello, TT, Dedova, I, Hardeman, EC ; https://orcid.org/, Gunning, PW ; https://orcid.org/, Hook, J, Appaduray, M, Hitchcock-DeGregori, S   +10 more
core   +1 more source

In Silico Prediction of Cross-Reactive Epitopes of Tropomyosin from Shrimp and Other Arthropods Involved in Allergy

Molecules, 2022
Tropomyosin in shellfish is considered a major cross-reactive allergen in house dust mites and cockroaches; however, the specific epitopes have not been elucidated. Therefore, this study aimed to identify the consensus antigenic determinant among shrimp,
Jirakrit Saetang, Varomyalin Tipmanee, Soottawat Benjakul   +2 more
doaj   +1 more source

Characterization of Contractile Proteins from Skeletal Muscle Using Gel-Based Top-Down Proteomics

Proteomes, 2019
The mass spectrometric analysis of skeletal muscle proteins has used both peptide-centric and protein-focused approaches. The term ‘top-down proteomics’ is often used in relation to studying purified proteoforms and their post-translational ...
Paul Dowling, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +3 more
doaj   +1 more source

Five-Year Trends in Biomarker Testing and Targeted Therapy for NSCLC: A Patient-Initiated Nationwide Survey in Japan. [PDF]

Cancer Sci
This nationwide survey reveals that comprehensive multigene testing for advanced NSCLC has rapidly expanded in Japan, steadily increasing the use of targeted therapies for rare oncogenic drivers. Despite these diagnostic advancements, approximately 30% of patients consistently remain untested, highlighting a persistent clinical gap in real‐world ...
Ikeda S, Hasegawa K, Takahama T, Kachi K, Yanagisawa A, Kawakami S, Yoshida M, Sakai M, Watanabe S, Nakagawa K.   +9 more
europepmc   +2 more sources

Integrative Structural Modelling of the Cardiac Thin Filament: Energetics at the Interface and Conservation Patterns Reveal a Spotlight on Period 2 of Tropomyosin

Bioinformatics and Biology Insights, 2012
Cardiomyopathies are a major health problem, with inherited cardiomyopathies, many of which are caused by mutations in genes encoding sarcomeric proteins, constituting an ever-increasing fraction of cases.
Sunitha S Margaret, John A. Mercer, James A. Spudich, Ramanathan Sowdhamini   +3 more
doaj   +1 more source

A Proteomic Study of Atherosclerotic Plaques in Men with Coronary Atherosclerosis

Diagnostics, 2019
Background: To study the changes in protein composition of atherosclerotic plaques at different stages of their development in coronary atherosclerosis using proteomics.
Ekaterina M. Stakhneva, Irina A. Meshcheryakova, Evgeny A. Demidov, Konstantin V. Starostin, Evgeny V. Sadovski, Sergey E. Peltek, Michael I. Voevoda, Alexander M. Chernyavskii, Alexander M. Volkov, Yuliya I. Ragino   +9 more
doaj   +1 more source

Allergenicity Reduction of Antarctic Krill (Euphausia superba) Tropomyosin through Glycosylation Modification

Shipin gongye ke-ji
Antarctic krill (Euphausia superba) was a premium protein resource. However, its strong allergenicity remained a problem that awaited resolution.
Shuqi ZHANG, Shuya WANG, Shuqi JIA, Kexin LIU, Na SUN   +4 more
doaj   +1 more source