Results 41 to 50 of about 53,903 (284)
Force Measurements From Myofibril to Filament
Frontiers in Physiology, 2022 Contractility, the generation of force and movement by molecular motors, is the hallmark of all muscles, including striated muscle. Contractility can be studied at every level of organization from a whole animal to single molecules.
Steven Marston
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, 2022 Kambhamettu, ChandraFilamentous objects are ubiquitous in biological images, and segmenting filament instances is fundamental for quantitative biological research.
Liu, Yi
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Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
Nature Communications, 2016 Recent data suggest that muscle contraction is regulated by thick filament mechano-sensing in addition to the well-known thin filament-mediated calcium signalling pathway. Here the authors provide direct evidence that myosin activation in skeletal muscle
L. Fusi, E. Brunello, Z. Yan, M. Irving
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Head-head interactions of resting myosin crossbridges in intact frog skeletal muscles, revealed by synchrotron x-ray fiber diffraction. [PDF]
PLoS ONE, 2012 The intensities of the myosin-based layer lines in the x-ray diffraction patterns from live resting frog skeletal muscles with full thick-thin filament overlap from which partial lattice sampling effects had been removed were analyzed to elucidate the ...
Kanji Oshima +3 more
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FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
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Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy
Cell Reports, 2017 Striated muscle contraction is regulated by the movement of tropomyosin over the thin filament surface, which blocks or exposes myosin binding sites on actin.
Meera C. Viswanathan +7 more
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Propulsion of an elastic filament in a shear-thinning fluid
Soft Matter, 2021 Viaa simple elastic swimmer actuated magnetically, we present a first study to examine how shear-thinning rheology impacts the fluid-structure interaction and hence the elastohydrodynamic propulsion performance at low Reynolds numbers.
Ke Qin +5 more
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Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind cooperatively to actin and regulate myosin. [PDF]
, 2011 Tropomyosin (Tm) is an evolutionarily conserved ?-helical coiled-coil protein, dimers of which form end-to-end polymers capable of associating with and stabilising actin-filaments and regulate myosin function. The fission yeast, Schizosaccharomyces pombe,
Duncan Sousa +15 more
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FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
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A Nebulin Ruler Does Not Dictate Thin Filament Lengths
, 2009 To generate force, striated muscle requires overlap between uniform-length actin and myosin filaments. The hypothesis that a nebulin ruler mechanism specifies thin filament lengths by targeting where tropomodulin (Tmod) caps the slow-growing, pointed end
Littlefield, Kimberly P. +4 more
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