Results 41 to 50 of about 1,111,006 (279)

Structural dynamics of troponin I during Ca2+-activation of cardiac thin filaments: a multi-site Förster resonance energy transfer study. [PDF]

PLoS ONE, 2012
A multi-site, steady-state Förster resonance energy transfer (FRET) approach was used to quantify Ca(2+)-induced changes in proximity between donor loci on human cardiac troponin I (cTnI), and acceptor loci on human cardiac tropomyosin (cTm) and F-actin ...
Hui Wang, Joseph M Chalovich, Gerard Marriott   +2 more
doaj   +1 more source

Structure of the hDmc1-ssDNA filament reveals the principles of its architecture [PDF]

, 2010
In eukaryotes, meiotic recombination is a major source of genetic diversity, but its defects in humans lead to abnormalities such as Down's, Klinefelter's and other syndromes.
Dmitry V Bugreev, Julie Hodgkinson, Yuriy L Chaban, Bugreev, DV, Orlova, Elena, Orlova, EV, Hodgkinson, J.L., Orlova Elena V., Chaban, Y.L., Bugreev, D.V., Andrei L Okorokov, Chaban Yuriy L., Okorokov, AL, Elena V Orlova, Okorokov, A.L., Hodgkinson, J, Bugreev Dmitry V., Chaban, YL, Okorokov Andrei L., Mazin, AV, Hodgkinson Julie, Mazin, A.V., Alexander V Mazin, Mazin Alexander V.   +23 more
core   +2 more sources

Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle

Nature Communications, 2016
Recent data suggest that muscle contraction is regulated by thick filament mechano-sensing in addition to the well-known thin filament-mediated calcium signalling pathway. Here the authors provide direct evidence that myosin activation in skeletal muscle
L. Fusi, E. Brunello, Z. Yan, M. Irving
doaj   +1 more source

A Nebulin Ruler Does Not Dictate Thin Filament Lengths [PDF]

, 2009
To generate force, striated muscle requires overlap between uniform-length actin and myosin filaments. The hypothesis that a nebulin ruler mechanism specifies thin filament lengths by targeting where tropomodulin (Tmod) caps the slow-growing, pointed end
Littlefield, Kimberly P., Fowler, Velia M., Castillo, Angelica, Littlefield, Ryan S., Nowak, Roberta   +4 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

Cell Reports, 2017
Striated muscle contraction is regulated by the movement of tropomyosin over the thin filament surface, which blocks or exposes myosin binding sites on actin.
Meera C. Viswanathan, William Schmidt, Michael J. Rynkiewicz, Karuna Agarwal, Jian Gao, Joseph Katz, William Lehman, Anthony Cammarato   +7 more
doaj   +1 more source

Head-head interactions of resting myosin crossbridges in intact frog skeletal muscles, revealed by synchrotron x-ray fiber diffraction. [PDF]

PLoS ONE, 2012
The intensities of the myosin-based layer lines in the x-ray diffraction patterns from live resting frog skeletal muscles with full thick-thin filament overlap from which partial lattice sampling effects had been removed were analyzed to elucidate the ...
Kanji Oshima, Yasunobu Sugimoto, Thomas C Irving, Katsuzo Wakabayashi   +3 more
doaj   +1 more source

Propulsion of an elastic filament in a shear-thinning fluid

Soft Matter, 2021
Via a simple elastic swimmer actuated magnetically, we present a first study to examine how shear-thinning rheology impacts the fluid-structure interaction and hence the elastohydrodynamic propulsion performance at low Reynolds numbers.
Ke Qin, Zhiwei Peng, Ye Chen, Herve Nganguia, Lailai Zhu, On Shun Pak   +5 more
openaire   +4 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source