Results 21 to 30 of about 1,111,006 (279)
Childhood-onset hypertrophic cardiomyopathy caused by thin-filament sarcomeric variants. [PDF]
J Med GenetUp to 20% of children with sarcomeric hypertrophic cardiomyopathy (HCM) have disease-causing variants in genes coding for thin-filament proteins. However, data on genotype-phenotype correlations for thin-filament disease are limited. This study describes
Norrish G +4 more
europepmc +3 more sources
Cells, 2023 As an essential component of the sarcomere, actin thin filament stems from the Z-disk extend toward the middle of the sarcomere and overlaps with myosin thick filaments. Elongation of the cardiac thin filament is essential for normal sarcomere maturation
Reiri Sono +18 more
doaj +1 more source
Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments
eLife, 2021 Regulated thin filaments (RTFs) tightly control striated muscle contraction through calcium binding to troponin, which enables tropomyosin to expose myosin-binding sites on actin. Myosin binding holds tropomyosin in an open position, exposing more myosin-
Quentin M Smith +4 more
doaj +1 more source
Modulation of Thin Filament Activation by Breakdown or Isoform Switching of Thin Filament Proteins [PDF]
Circulation Research, 2003 In the heart, the contractile apparatus is adapted to the specific demands of the organ for continuous rhythmic contraction. The specialized contractile properties of heart muscle are attributable to the expression of cardiac-specific isoforms of contractile proteins.
Marston, S, Redwood, C
openaire +3 more sources
Leiomodin creates a leaky cap at the pointed end of actin-thin filaments.
PLoS Biology, 2020 Improper lengths of actin-thin filaments are associated with altered contractile activity and lethal myopathies. Leiomodin, a member of the tropomodulin family of proteins, is critical in thin filament assembly and maintenance; however, its role is under
Dmitri Tolkatchev +7 more
doaj +1 more source
Thermal Activation of Thin Filaments in Striated Muscle
Frontiers in Physiology, 2020 In skeletal and cardiac muscles, contraction is triggered by an increase in the intracellular Ca2+ concentration. During Ca2+ transients, Ca2+-binding to troponin C shifts the “on–off” equilibrium of the thin filament state toward the “on” sate ...
Shuya Ishii +7 more
doaj +1 more source
Polymeric filament thinning and breakup in microchannels [PDF]
Physical Review E, 2008 The effects of elasticity on filament thinning and breakup are investigated in microchannel cross flow. When a viscous solution is stretched by an external immiscible fluid, a low 100 ppm polymer concentration strongly affects the breakup process, compared to the Newtonian case.
Arratia, Paulo E +2 more
openaire +5 more sources
Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers
Frontiers in Physiology, 2020 It has been shown that not only calcium but also strong binding myosin heads contribute to thin filament activation in isometrically contracting animal fast-twitch and cardiac muscle preparations. This behavior has not been studied in human muscle fibers
Alfredo Jesus López-Dávila +9 more
doaj +1 more source
Filament compliance influences cooperative activation of thin filaments and the dynamics of force production in skeletal muscle. [PDF]
PLoS Computational Biology, 2012 Striated muscle contraction is a highly cooperative process initiated by Ca²⁺ binding to the troponin complex, which leads to tropomyosin movement and myosin cross-bridge (XB) formation along thin filaments. Experimental and computational studies suggest
Bertrand C W Tanner +2 more
doaj +1 more source
A Model of Calcium Activation of the Cardiac Thin Filament
, 2016 The cardiac thin filament regulates actomyosin interactions through calcium-dependent alterations in the dynamics of cardiac troponin and tropomyosin. Over the past several decades, many details of the structure and function of the cardiac thin filament ...
Edward P. Manning (2174344) +2 more
core +8 more sources