Results 11 to 20 of about 53,903 (284)

Structure and Orientation of Troponin in the Thin Filament [PDF]

Journal of Biological Chemistry, 2009
The troponin complex on the thin filament plays a crucial role in the regulation of muscle contraction. However, the precise location of troponin relative to actin and tropomyosin remains uncertain. We have developed a method of reconstructing thin filaments using single particle analysis that does not impose the helical symmetry of actin and is ...
Paul, D M, Morris, E P, Kensler, R W, Squire, JM   +3 more
openaire   +4 more sources

Alterations in thin filament length during postnatal skeletal muscle development and aging in mice

Frontiers in Physiology, 2014
The lengths of the sarcomeric thin filaments vary in a skeletal muscle-specific manner and help specify the physiological properties of skeletal muscle.
David S Gokhin, Emily A Dubuc, Kendra Q Lian, Luanne L Peters, Velia M Fowler   +4 more
doaj   +2 more sources

Titin Isoform Size is Not Correlated with Thin Filament Length in Rat Skeletal Muscle

Frontiers in Physiology, 2014
The mechanisms controlling thin filament length in muscle remain controversial. It was recently reported that thin filament length was related to titin size, and that the latter might be involved in thin filament length determination.
Marion Lewis Greaser, Jonathan M Pleitner   +1 more
doaj   +2 more sources

Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates. [PDF]

PLoS ONE, 2012
The contractile response of the heart can be altered by disease-related protein modifications to numerous contractile proteins. By utilizing an IAANS labeled fluorescent troponin C, [Formula: see text], we examined the effects of ten disease-related ...
Bin Liu, Svetlana B Tikunova, Kristopher P Kline, Jalal K Siddiqui, Jonathan P Davis   +4 more
doaj   +2 more sources

Thin Filament Mutations [PDF]

Circulation Research, 2011
Sixteen years ago, mutations in cardiac troponin (Tn)T and α-tropomyosin were linked to familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β-myosin heavy chain to a disease of the cardiac sarcomere. From the outset, studies suggested that mutations in the regulatory thin filament caused a complex, heterogeneous ...
Jil C. Tardiff
openaire   +3 more sources

Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties. [PDF]

PLoS ONE, 2014
Adrenergic stimulation modulates cardiac function by altering the phosphorylation status of several cardiac proteins. The Troponin complex, which is the Ca(2+) sensor for cardiac contraction, is a hot spot for adrenergic phosphorylation. While the effect
Bin Liu, Joseph J Lopez, Brandon J Biesiadecki, Jonathan P Davis   +3 more
doaj   +2 more sources

Modulation of Thin Filament Activation by Breakdown or Isoform Switching of Thin Filament Proteins [PDF]

Circulation Research, 2003
In the heart, the contractile apparatus is adapted to the specific demands of the organ for continuous rhythmic contraction. The specialized contractile properties of heart muscle are attributable to the expression of cardiac-specific isoforms of contractile proteins.
Marston, S, Redwood, C
openaire   +4 more sources

A Model of Calcium Activation of the Cardiac Thin Filament

, 2016
The cardiac thin filament regulates actomyosin interactions through calcium-dependent alterations in the dynamics of cardiac troponin and tropomyosin. Over the past several decades, many details of the structure and function of the cardiac thin filament ...
Edward P. Manning (2174344), Steven D. Schwartz (1355667), Jil C. Tardiff (2174342)   +2 more
core   +8 more sources

Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing. [PDF]

Proc Natl Acad Sci U S A, 2021
Myosin-based regulation in the heart muscle modulates the number of myosin motors available for interaction with calcium-regulated thin filaments, but the signaling pathways mediating the stronger contraction triggered by stretch between heartbeats or by
Park-Holohan SJ, Brunello E, Kampourakis T, Rees M, Irving M, Fusi L.   +5 more
europepmc   +2 more sources

Childhood-onset hypertrophic cardiomyopathy caused by thin-filament sarcomeric variants. [PDF]

J Med Genet
Up to 20% of children with sarcomeric hypertrophic cardiomyopathy (HCM) have disease-causing variants in genes coding for thin-filament proteins. However, data on genotype-phenotype correlations for thin-filament disease are limited. This study describes
Norrish G, Gasparini M, Field E, Cervi E, Kaski JP.   +4 more
europepmc   +2 more sources