Results 11 to 20 of about 1,111,006 (279)
Structure and Orientation of Troponin in the Thin Filament [PDF]
Journal of Biological Chemistry, 2009 The troponin complex on the thin filament plays a crucial role in the regulation of muscle contraction. However, the precise location of troponin relative to actin and tropomyosin remains uncertain. We have developed a method of reconstructing thin filaments using single particle analysis that does not impose the helical symmetry of actin and is ...
Paul, D M +3 more
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Alterations in thin filament length during postnatal skeletal muscle development and aging in mice
Frontiers in Physiology, 2014 The lengths of the sarcomeric thin filaments vary in a skeletal muscle-specific manner and help specify the physiological properties of skeletal muscle.
David S Gokhin +4 more
doaj +2 more sources
Circulation Research, 2011 Sixteen years ago, mutations in cardiac troponin (Tn)T and α-tropomyosin were linked to familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β-myosin heavy chain to a disease of the cardiac sarcomere. From the outset, studies suggested that mutations in the regulatory thin filament caused a complex, heterogeneous ...
Jil C. Tardiff
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Titin Isoform Size is Not Correlated with Thin Filament Length in Rat Skeletal Muscle [PDF]
Frontiers in Physiology, 2014 The mechanisms controlling thin filament length in muscle remain controversial. It was recently reported that thin filament length was related to titin size, and that the latter might be involved in thin filament length determination.
Marion Lewis Greaser +1 more
doaj +2 more sources
Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties. [PDF]
PLoS ONE, 2014 Adrenergic stimulation modulates cardiac function by altering the phosphorylation status of several cardiac proteins. The Troponin complex, which is the Ca(2+) sensor for cardiac contraction, is a hot spot for adrenergic phosphorylation. While the effect
Bin Liu +3 more
doaj +2 more sources
The Effect of Inkjet Ink Composition on Rheology And Jetting Behaviour [PDF]
, 2011 This work presents recent results on the way linear and non linear viscoelastic properties of the fluids affect the jetting mechanism. Recent progress on quantitative characterising both high frequency linear (LVE) and non-linear (NLVE) viscoelasticity ...
core +9 more sources
Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy [PDF]
Journal of Molecular BiologyJosé Renato Pinto +2 more
exaly +2 more sources
Cardiac thin filament regulation [PDF]
Pflügers Archiv - European Journal of Physiology, 2008 Myocardial contraction is initiated upon the release of calcium into the cytosol from the sarcoplasmic reticulum following membrane depolarization. The fundamental physiological role of the heart is to pump an amount blood that is determined by the prevailing requirements of the body.
Tomoyoshi, Kobayashi +2 more
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Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates. [PDF]
PLoS ONE, 2012 The contractile response of the heart can be altered by disease-related protein modifications to numerous contractile proteins. By utilizing an IAANS labeled fluorescent troponin C, [Formula: see text], we examined the effects of ten disease-related ...
Bin Liu +4 more
doaj +1 more source
PLoS Genetics, 2022 Myofibrils within skeletal muscle are composed of sarcomeres that generate force by contraction when their myosin-rich thick filaments slide past actin-based thin filaments.
Joachim Berger +5 more
doaj +1 more source