Filament compliance influences cooperative activation of thin filaments and the dynamics of force production in skeletal muscle. [PDF]
PLoS Computational Biology, 2012 Striated muscle contraction is a highly cooperative process initiated by Ca²⁺ binding to the troponin complex, which leads to tropomyosin movement and myosin cross-bridge (XB) formation along thin filaments. Experimental and computational studies suggest
Bertrand C W Tanner +2 more
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Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle
eLife, 2021 Time-resolved X-ray diffraction of isolated fast-twitch muscles of mice was used to show how structural changes in the myosin-containing thick filaments contribute to the regulation of muscle contraction, extending the previous focus on regulation by the
Cameron Hill +4 more
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The Drosophila formin Fhos is a primary mediator of sarcomeric thin-filament array assembly
eLife, 2016 Actin-based thin filament arrays constitute a fundamental core component of muscle sarcomeres. We have used formation of the Drosophila indirect flight musculature for studying the assembly and maturation of thin-filament arrays in a skeletal muscle ...
Arkadi Shwartz +3 more
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Clinical Features and Prospective Outcomes of Thin-Filament Hypertrophic Cardiomyopathy: Intrinsic Data and Comparative Insights from Other Cohorts. [PDF]
J Clin MedBackground/Objectives: Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease. The most frequently mutated genes encode proteins of the thick filament of the sarcomere, while mutations in thin-filament genes are rare findings in HCM ...
Chumakova OS +2 more
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Actin filament attachments for sustained motility in vitro are maintained by filament bundling. [PDF]
PLoS ONE, 2012 We reconstructed cellular motility in vitro from individual proteins to investigate how actin filaments are organized at the leading edge. Using total internal reflection fluorescence microscopy of actin filaments, we tested how profilin, Arp2/3, and ...
Xiaohua Hu, Jeffrey R Kuhn
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Application of the core shell model for strengthening polymer filament interfaces
Journal of Materials Research and Technology, 2022 While surface segregation has been intensively studied in thin films, relatively little has been investigated in filament geometries. In contrast to thin films, the filament surface forms a continuum, with interactions both at the free air and internal ...
Yu-Chung Lin +11 more
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Journal of Limnology, 2016 Recent studies have shown that the filamentous cyanobacterium Aphanizomenon gracile Lemmermann, strain SAG 31.79, consists of two types of filaments that differ in thickness.
Lukasz Wejnerowski +3 more
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Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy
Scientific Reports, 2022 Cardiomyopathies have unresolved genotype–phenotype relationships and lack disease-specific treatments. Here we provide a framework to identify genotype-specific pathomechanisms and therapeutic targets to accelerate the development of precision medicine.
Francesca Margara +11 more
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Frontiers in Physiology, 2022 Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow ...
Zabed Mahmud +13 more
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Structural dynamics of troponin I during Ca2+-activation of cardiac thin filaments: a multi-site Förster resonance energy transfer study. [PDF]
PLoS ONE, 2012 A multi-site, steady-state Förster resonance energy transfer (FRET) approach was used to quantify Ca(2+)-induced changes in proximity between donor loci on human cardiac troponin I (cTnI), and acceptor loci on human cardiac tropomyosin (cTm) and F-actin ...
Hui Wang +2 more
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