Results 31 to 40 of about 1,111,006 (279)
Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle
eLife, 2021 Time-resolved X-ray diffraction of isolated fast-twitch muscles of mice was used to show how structural changes in the myosin-containing thick filaments contribute to the regulation of muscle contraction, extending the previous focus on regulation by the
Cameron Hill +4 more
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The Drosophila formin Fhos is a primary mediator of sarcomeric thin-filament array assembly
eLife, 2016 Actin-based thin filament arrays constitute a fundamental core component of muscle sarcomeres. We have used formation of the Drosophila indirect flight musculature for studying the assembly and maturation of thin-filament arrays in a skeletal muscle ...
Arkadi Shwartz +3 more
doaj +1 more source
Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle. [PDF]
Sci Adv, 2020 Regulating the thin-filament length in muscle is crucial for controlling the number of myosin motors that generate power. The giant protein nebulin forms a long slender filament that associates along the length of the thin filament in skeletal muscle ...
Kiss B +10 more
europepmc +2 more sources
Actin filament attachments for sustained motility in vitro are maintained by filament bundling. [PDF]
PLoS ONE, 2012 We reconstructed cellular motility in vitro from individual proteins to investigate how actin filaments are organized at the leading edge. Using total internal reflection fluorescence microscopy of actin filaments, we tested how profilin, Arp2/3, and ...
Xiaohua Hu, Jeffrey R Kuhn
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Application of the core shell model for strengthening polymer filament interfaces
Journal of Materials Research and Technology, 2022 While surface segregation has been intensively studied in thin films, relatively little has been investigated in filament geometries. In contrast to thin films, the filament surface forms a continuum, with interactions both at the free air and internal ...
Yu-Chung Lin +11 more
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Journal of Limnology, 2016 Recent studies have shown that the filamentous cyanobacterium Aphanizomenon gracile Lemmermann, strain SAG 31.79, consists of two types of filaments that differ in thickness.
Lukasz Wejnerowski +3 more
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Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy
Scientific Reports, 2022 Cardiomyopathies have unresolved genotype–phenotype relationships and lack disease-specific treatments. Here we provide a framework to identify genotype-specific pathomechanisms and therapeutic targets to accelerate the development of precision medicine.
Francesca Margara +11 more
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Frontiers in Physiology, 2022 Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow ...
Zabed Mahmud +13 more
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Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing [PDF]
, 2021 Myosin-based regulation in the heart muscle modulates the number of myosin motors available for interaction with calcium-regulated thin filaments, but the signaling pathways mediating the stronger contraction triggered by stretch between heartbeats or by
Park-Holohan, So Jin +5 more
core +1 more source
Force Measurements From Myofibril to Filament
Frontiers in Physiology, 2022 Contractility, the generation of force and movement by molecular motors, is the hallmark of all muscles, including striated muscle. Contractility can be studied at every level of organization from a whole animal to single molecules.
Steven Marston
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