Results 51 to 60 of about 53,903 (284)

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast. [PDF]

, 2010
Tropomyosin (Tm) is a conserved dimeric coiled-coil protein, which forms polymers that curl around actin filaments in order to regulate actomyosin function.
Mulvihill, Daniel P., Arthur T. Coulton, East, Daniel A., Coulton, Arthur T., Lehman, William, William Lehman, Daniel A. East, Daniel P. Mulvihill, Galinska-Rakoczy, Agnieszka, Agnieszka Galinska-Rakoczy   +9 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Thin-Filament Mutations, Hypertrophic Cardiomyopathy, and Risk ∗

Journal of the American College of Cardiology, 2014
On occasion, a study’s negative findings overshadow its positive results, as in the report from Coppini et al. [(1)][1] in this issue of the Journal . In this study, the risk of sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM) as a result of thin-filament mutations ...
Sherrid, Mark V., Arabadjian, Milla, Koulova, Anna   +2 more
openaire   +2 more sources

Mode of caldesmon binding to smooth muscle thin filament: possible projection of the amino-terminal of caldesmon from native thin filament

, 1995
The structure of smooth muscle thin filament was examined by various electron microscopy techniques, with special attention to the mode of caldesmon binding.
Katayama, E., Ikebe, M.
core   +1 more source

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source

The molecular basis of thin filament activation: from single molecule to muscle

Scientific Reports, 2017
For muscles to effectively power locomotion, trillions of myosin molecules must rapidly attach and detach from the actin thin filament. This is accomplished by precise regulation of the availability of the myosin binding sites on actin (i.e. activation).
Thomas Longyear, Sam Walcott, Edward P. Debold   +2 more
doaj   +1 more source

Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions. [PDF]

PLoS ONE, 2010
Isometric muscle contraction, where force is generated without muscle shortening, is a molecular traffic jam in which the number of actin-attached motors is maximized and all states of motor action are trapped with consequently high heterogeneity.
Shenping Wu, Jun Liu, Mary C Reedy, Richard T Tregear, Hanspeter Winkler, Clara Franzini-Armstrong, Hiroyuki Sasaki, Carmen Lucaveche, Yale E Goldman, Michael K Reedy, Kenneth A Taylor   +10 more
doaj   +1 more source

Near‐Field Electrospinning Micro‐Printhead Achieves Precise Control of Nanofiber Deposition

Advanced Engineering Materials, EarlyView.
A micro‐printhead for near‐field electrospinning enables reproducible deposition of polymer nanofibers with diameters below 50 nm. Systematic parameter studies uncover the mechanisms linking operating conditions to fiber morphology, paving the way for precise and low‐cost nanoscale 3D manufacturing.As a high‐resolution, cost‐effective, and rapid ...
Han Xu, Dario Mager, Jan G. Korvink
wiley   +1 more source

Cross-bridge (XB) binding stabilizes and augments thin filament activation.

, 2012
(A) Steady-state thin filament activation is plotted against pCa for simulations where standard parameter values were applied (see Figure 3), in the presence and absence of kinetic forms of cooperativity.
Thomas L. Daniel (109686), Michael Regnier (76653), Bertrand C. W. Tanner (165537)   +2 more
core   +1 more source