Mode of caldesmon binding to smooth muscle thin filament: possible projection of the amino-terminal of caldesmon from native thin filament [PDF]
The structure of smooth muscle thin filament was examined by various electron microscopy techniques, with special attention to the mode of caldesmon binding.
Katayama, E., Ikebe, M.
core +1 more source
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Thin-Filament Mutations, Hypertrophic Cardiomyopathy, and Risk ∗
On occasion, a study’s negative findings overshadow its positive results, as in the report from Coppini et al. [(1)][1] in this issue of the Journal . In this study, the risk of sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM) as a result of thin-filament mutations ...
Sherrid, Mark V. +2 more
openaire +2 more sources
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
The molecular basis of thin filament activation: from single molecule to muscle
For muscles to effectively power locomotion, trillions of myosin molecules must rapidly attach and detach from the actin thin filament. This is accomplished by precise regulation of the availability of the myosin binding sites on actin (i.e. activation).
Thomas Longyear +2 more
doaj +1 more source
Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions. [PDF]
Isometric muscle contraction, where force is generated without muscle shortening, is a molecular traffic jam in which the number of actin-attached motors is maximized and all states of motor action are trapped with consequently high heterogeneity.
Shenping Wu +10 more
doaj +1 more source
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur +5 more
wiley +1 more source
Computer modeling of pneumatic formation of superthin fibres [PDF]
Dynamics of a novel pneumatic process of superthin fibres formation from polymer melts in supersonic air jets in the Laval nozzle is studied using computer simulation.
Leszek Jarecki +3 more
doaj +1 more source
The matching of a “one-dimensional” numerical simulation and experiment results for low viscosity Newtonian and non-Newtonian fluids during fast filament stretching and subsequent break-up [PDF]
This paper develops a model for fast filament stretching, thinning, and break-up for Newtonian and non-Newtonian fluids, and the results are compared against experimental data where fast filament relaxation occurs. A 1D approximation was coupled with the
core +2 more sources
Low‐voltage FIB‐SEM tomography combined with a image preprocessing pipeline improves phase contrast and enables reliable machine‐learning segmentation of conductive networks in lithium‐ion battery electrodes. Structural descriptors are extracted from segmented images, done semimanually and automated, and compared.
Lisa Beran +6 more
wiley +1 more source

