Results 61 to 70 of about 231,445 (248)

Evaluating whole genome sequence data from the Genetic Absence Epilepsy Rat from Strasbourg and its related non-epileptic strain. [PDF]

PLoS ONE, 2017
The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are an inbreed Wistar rat strain widely used as a model of genetic generalised epilepsy with absence seizures.
Pablo M Casillas-Espinosa, Kim L Powell, Mingfu Zhu, C Ryan Campbell, Jessica M Maia, Zhong Ren, Nigel C Jones, Terence J O'Brien, Slavé Petrovski   +8 more
doaj   +1 more source

Quantification of Single‐Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility

Advanced Science, EarlyView.
Cysteine attracts interest due to its unique electrochemical activity and emerging relationship with disulfidptosis. This study develops a new electrochemical nanosensor, which represents the first of its kind capable of detecting intracellular cysteine for various types of tumor cells and primary tumor cells in mice to evaluate disulfidptosis ...
Congcong Zhang, Xiangdi Zhang, Shushen Li, Yuyang Li, Bei Yuan, Mingshuang Zheng, Shuo Zhang, Fangping Yuan, Min Jia, Lixia Lu, Jun Zhou, Zhenguo Zhang, Xin Du   +12 more
wiley   +1 more source

DNA methylation in necrotizing enterocolitis

Expert Reviews in Molecular Medicine
Epigenetic modifications, such as DNA methylation, are enzymatically regulated processes that directly impact gene expression patterns. In early life, they are central to developmental programming and have also been implicated in regulating inflammatory ...
Lauren C. Frazer, Yukihiro Yamaguchi, Dhirendra K. Singh, Natalia S. Akopyants, Misty Good   +4 more
doaj   +1 more source

Influence of access cavity design on the fracture resistance and root canal filling efficacy in simulated young permanent molars using cone-beam computed tomography: An in vitro study

Endodontology, 2020
Aims: The aim of this study is to evaluate the influence of access cavity designs on the fracture resistance and root canal filling efficacy of simulated young permanent molars.
N Greeshma Reddy, Sreebala G Naga, M G Manoj Kumar, N C H Srinivas, Shanthan Mettu, Dwitha Animireddy   +5 more
doaj   +1 more source

Neurobehavioral Assessment of Sensorimotor Function in Autism Using Smartphone Technology

Autism Research, EarlyView.
ABSTRACT Differences in sensorimotor processing represent an important, yet underrecognized, feature of autism; typically assessed through subjective observations, which, although important, are susceptible to biases. To complement these observations, a more objective approach to assess sensorimotor function may be possible through reflex‐based ...
Kayleigh D. Gultig, Cornelis P. Boele, Lotte E. M. Roggeveen, Ting Fang Soong, Seth Sherry, Caroline Jung, Sara Milosevska, Anton Uvarov, Khalid Benhassan, Said Ait BenAli, Yasmine Ahajoui, Valeria Carpio‐Arias, Sander Lindeman, Sebastiaan K. E. Koekkoek, Esra Sefik, Myrthe J. Ottenhoff, Samuel S.‐H. Wang, Chris I. De Zeeuw, Abdeslem El Idrissi, Henk‐Jan Boele   +19 more
wiley   +1 more source

Influence of probiotic supplementation on the developing microbiota in human preterm neonates

Gut Microbes, 2020
Background Oral administration of probiotic bacteria to preterm neonates has been recommended to prevent the development of necrotizing enterocolitis (NEC).
Niels van Best, Sonja Trepels-Kottek, Paul Savelkoul, Thorsten Orlikowsky, Mathias W. Hornef, John Penders   +5 more
doaj   +1 more source

Enhanced Tissue Integration During Cartilage RepairIn VitroCan Be Achieved by Inhibiting Chondrocyte Death at the Wound Edge [PDF]

, 2009
Objective: Experimental wounding of articular cartilage results in cell death at the lesion edge. The objective of this study was to investigate whether inhibition of this cell death results in enhanced integrative cartilage repair.
Archer, Charles W., Burdon, Drew, Duance, Victor C., Gilbert, Sophie J., Gonzalez, Lee G., Khan, Ilyas M., Singhrao, Simarjit Kaur, Thomson, Brian M.   +7 more
core   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Prognostic factors and treatment impact on overall survival in patients with renal neuroendocrine tumour

BJUI Compass
Background Renal neuroendocrine neoplasms (R‐NEN) are exceptionally rare tumours characterized by high mortality rates. Objective The objective of this study is to analyse prognostic factors and treatment impact on overall survival in patients with R‐NEN.
Olamide O. Omidele, Christopher Connors, Nikhil Wainganker, Ketan Badani, John Sfakianos, Reza Mehrazin, Isuru Jayaratna   +6 more
doaj   +1 more source

Surgery for intestinal injuries in very preterm infants: a Norwegian population-based study with a new approach to disease classification

BMJ Paediatrics Open
Objective To evaluate population-based data on very preterm infants (<32 weeks gestation) operated for intestinal injuries, focusing on necrotising enterocolitis (NEC) and focal intestinal perforation (FIP).Design Nationwide, population-based registry
Claus Klingenberg, Ragnhild Støen, Kristin Bjørnland, Hans Jørgen Stensvold, Arild Rønnestad, Nina Clare Hapnes, Thorstein Sæter, Hans Jørgen Timm Guthe, Sissel Jennifer Moltu   +8 more
doaj   +1 more source