Results 41 to 50 of about 36,393 (292)

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Real Time Network Traffic Monitoring [PDF]

, 1999
This paper looks at the problems of real time network traffic monitoring. Some of the existing approaches are reviewed, looking at both simple filtering systems and also systems based on the use of finite state machines that can report specific events or
Tripp, Gerald
core  

Biomarker Potential of Interleukin-6 in Differentiating Necrotizing Enterocolitis from Late-Onset Sepsis in Neonates Born Preterm

Journal of Pediatrics: Clinical Practice
Objective: Interleukin-6 (IL-6) is an early biomarker for sepsis and necrotizing enterocolitis (NEC). We assessed IL-6's ability to differentiate between late-onset sepsis (LOS) and NEC and between medical and surgical NEC.
Ceren Imren, MD, Vivian de Groot, MD, Claudia M.G. Keyzer-Dekker, MD, PhD, Irwin K.M. Reiss, MD, PhD, Sten P. Willemsen, PhD, Marijn J. Vermeulen, MD, PhD, H. Rob Taal, MD, PhD   +6 more
doaj   +1 more source

Sustainable Productivity Growth in Agriculture: The Role of Shifts in R&D Investments and Technology

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT The objective of the paper is to evaluate the long‐term prospects of sustainable productivity growth linked to plausible assumptions on public agricultural R&D investments as the key productivity driver. Second, it investigates the role of changing R&D focus from yield maximization to input saving technologies (fertilizers and pesticides). The
Zuzana Smeets Křístková, Michiel van Dijk, Robert M'Barek, Hans van Meijl, Tomas Ratinger   +4 more
wiley   +1 more source

Design and Validation of Blast Non-propagation Wall for Multi-Compartmented Explosive Storage Structure of Capacity 5T NEC per Compartment

Defence Science Journal, 2018
Conventional magazines for hazard division 1.1 are constructed using bricks and reinforced cement concrete (RCC) for which storage inside quantity distance (SIQD) is 2.4 W1/3 m, where W is Net Explosive Content in kg. New composite called laced reinforced concrete (LRC) has been developed recently, for which SIQD has been reduced up to 0.5 W1/3 m.
Rajiv Narang, Ghanshyam Kumar Mishra, Rajesh Kumar Tanwar, Rajesh Mishra, Prabhanjan Kumar Thakur   +4 more
openaire   +2 more sources

North American Delphi Consensus Study on Sinonasal Malignancy Survivorship Care

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Survival for patients with sinonasal cancers has improved over the past decades, but there are no dedicated survivorship guidelines for this cohort. Objective To understand experts’ priorities and perspectives on key survivorship tenets (surveillance, second tumor screening, toxicity, and symptom management).
Matheus Sewastjanow‐Silva, Samagra Jain, Rita Snyder, Erin L. McKean, Ralph Abi Hachem, Nithin D. Adappa, J. Ken Byrd, Ricardo L. Carrau, Marc A. Cohen, Ivan H. El‐Sayed, Mathew N. Geltzeiler, Ehab Y. Hanna, Edward C. Kuan, Nyall R. London Jr., Zoukaa B. Sargi, Carl H. Snyderman, Marilene B. Wang, Ian J. Witterick, Shirley Y. Su   +18 more
wiley   +1 more source

NEC Laboratories America [PDF]

, 2015
We present a data analytics system, Odyssey, that is be-ing developed at NEC Labs in collaboration with NEC’s commercial business units and our academic collaborators.
Jagan Sankaranarayanan, Jeff Lefevre, Neoklis Polyzotis, Junichi Tatemura   +3 more
core  

Elevated DUOX2 levels correlate with necrotizing enterocolitis development

Frontiers in Cellular and Infection Microbiology
BackgroundNeonatal necrotizing enterocolitis (NEC) is a life-threatening intestinal disease primarily affecting preterm infants. Although the exact pathophysiology remains unclear, immune responses and redox reactions play crucial roles in its ...
Wenqiang Sun, Wenqiang Sun, Xue Liu, Xue Liu, Jiahui Huang, Jiahui Huang, Yihui Li, Yihui Li, Wei Zhai, Xinyun Jin, Xinyun Jin, Lili Li, Xueping Zhu, Xueping Zhu   +13 more
doaj   +1 more source

Metabolomic signatures distinguish the impact of formula carbohydrates on disease outcome in a preterm piglet model of NEC

Microbiome, 2018
Background Major risk factors for necrotizing enterocolitis (NEC) include premature birth and formula feeding in the context of microbial colonization of the gastrointestinal tract. We previously showed that feeding formula composed of lactose vs.
Lee Call, Barbara Stoll, Berthe Oosterloo, Nadim Ajami, Fariha Sheikh, Anja Wittke, Rosaline Waworuntu, Brian Berg, Joseph Petrosino, Oluyinka Olutoye, Douglas Burrin   +10 more
doaj   +1 more source