Results 31 to 40 of about 36,393 (292)
Advanced Science, EarlyView.This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang +10 more
wiley +1 more source
A design view of capability [PDF]
, 2008 In order to optimise resource deployment in a rapid changing operational environment, capability has received increasing concerns in terms of maximising the utilisation of resources.
Whitfield, Ian +6 more
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Advanced Science, EarlyView.Schematic illustration of a tumor microenvironment‐responsive nanoreactor for imaging‐guided induction of disulfidptosis in pancreatic cancer via metabolic interference and redox catalysis. (A) Stepwise fabrication of Pht@HMnO2‐HA, including MnO2 growth on a SiO2 template, template removal to form hollow mesoporous MnO2, Pht loading, and subsequent ...
Rui Fu +10 more
wiley +1 more source
An ant colony genetic fusion routing algorithm based on soft define network
IET Networks, EarlyView., 2022 Abstract Aiming at the problem that there are many paths in data forwarding in soft define network (SDN) network, and the optimal path is difficult to find, combined with the advantages of ant colony algorithm and Genetic algorithm (GA), a routing control strategy based on the ant colony genetic fusion algorithm is proposed.
Kaixin Zhao, Yong Wei, Yang Zhang
wiley +1 more source
An antenna design for PANSAT using NEC. [PDF]
, 1991 In this thesis the Numerical Electromagnetics Code (NEC) is used to design an omnidirectional antenna for the Petite Amateur Navy Satellite (PANSAT).
Ellrick, Daniel A.
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Advanced Science, EarlyView.Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong +20 more
wiley +1 more source
Is photovoltaic power a cost-effective energy solution for rural peoples in western Sudan? [PDF]
, 2006 Sudan like most poor countries suffers from a deficiency in the supply of electrical power, especially for rural areas. Less than 10% of the total population, can benefit from the national grid connection.
Croxford, B, Rizig, M
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BMJ Paediatrics OpenIntroduction The main risk factors of necrotising enterocolitis (NEC) are prematurity and low birth weight. The aim of our study was to identify risk factors for NEC in patients with duct-dependent congenital heart disease (CHD).Study design Newborns ...
Isabelle Ligi +8 more
doaj +1 more source
Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
TÜBİTAK 1MV Accelerator Mass Spectrometer Designed for 14C, 10Be, 26Al, 41Ca, 129I
Bulletin of the Mineral Research and Exploration, 2023 A 1 MV Accelerator Mass Spectrometer (AMS) was established at TÜBİTAK, MRC Türkiye in December 2015. The 1MV TÜBİTAK AMS system is based on a Pelletron tandem accelerator, operating up to 1.1MV.
Furkan Kulak +2 more
doaj +1 more source