Results 101 to 110 of about 2,201,362 (430)

Pancbeatic Hemorrhage, Pancreatic Necrosis, and Fat-Necrosis [PDF]

The American Journal of the Medical Sciences, 1895
n ...
openaire   +2 more sources

C-Jun N-terminal kinase 2 promotes liver injury via the mitochondrial permeability transition after hemorrhage and resuscitation [PDF]

, 2012
Hemorrhagic shock leads to hepatic hypoperfusion and activation of mitogen-activated stress kinases (MAPK) like c-Jun N-terminal kinase (JNK) 1 and 2. Our aim was to determine whether mitochondrial dysfunction leading to hepatic necrosis and apoptosis ...
Czerny, Christoph, Lehnert, Mark, Lemasters, John J., Maldonado, Eduardo N., Marzi, Ingo, Theruvath, Tom Prakash, Zhong, Zhi   +6 more
core   +2 more sources

A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate.

New England Journal of Medicine, 1999
BACKGROUND Patients treated with methotrexate for rheumatoid arthritis often improve but continue to have active disease. This study was undertaken to determine whether the addition of etanercept, a soluble tumor necrosis factor receptor (p75):Fc fusion ...
M. Weinblatt, J. Kremer, A. Bankhurst, K. Bulpitt, R. Fleischmann, Robert I. Fox, C. G. Jackson, M. Lange, D. Burge   +8 more
semanticscholar   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

The role of cholestasis in brain hippocampus trauma in male Wistar rat

یافته‌های نوین در علوم زیستی, 2017
In cholestasis syndrome, the change of bile acids, salts, endotoxins and opioidsis is accompanied with hepaticencephalopathy and brain trauma; therefore, in this study, the histopathological changes of hippocampus after bile duct ligation were ...
Delaram Eslimi Esfahani, Shahrbanoo Oryan, Mohammad iNabiun, Manijeh Karimian Peiro   +3 more
doaj  

Enhancement of experimental metastasis by tumor necrosis factor [PDF]

, 1993
The influence of endogenous and exogenous tumor necrosis factor (TNF) on metastasis was investigated in an experimental fibrosarcoma metastasis model.
Echtenacher, Bernd, Falk, Werner, Männel, Daniela N., Orosz, P., Rüschoff, J., Weber, D.   +5 more
core   +2 more sources

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Skokie, the ACLU and the Endurance of Democratic Theory [PDF]

, 1979
ZnO nanorods (NRs) with high surface area to volume ratio and biocompatibility is used as an efficient photosensitizer carrier system and at the same time providing intrinsic white light needed to achieve cancer cell necrosis.
Asif, Muhammad, Larsson, Per-Olof, Nour, Omer, Sultana, Kishwar, Willander, Magnus   +4 more
core   +2 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Structure Regularized Attentive Network for Automatic Femoral Head Necrosis Diagnosis and Localization [PDF]

arXiv, 2022
In recent years, several works have adopted the convolutional neural network (CNN) to diagnose the avascular necrosis of the femoral head (AVNFH) based on X-ray images or magnetic resonance imaging (MRI). However, due to the tissue overlap, X-ray images are difficult to provide fine-grained features for early diagnosis.
arxiv