Results 61 to 70 of about 1,016,672 (340)

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

Acute and subchronic effects of petroleum on the freshwater fish Hoplias aff. malabaricus

open access: yesBrazilian Journal of Biology, 2022
Petroleum water soluble fraction (WSF) impairs organisms, but damages may vary among cell and tissue levels. The aim of the present study was to evaluate the acute (24 h, 48 h, 72 h) and subchronic effects (36 days) of WSF (0%, 25% and 100%) in juveniles
R. M. Santos   +6 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

The use of papain gel cream and sunflower oil in promoting healing in a wound in dogs: three case reports

open access: yesArquivo Brasileiro de Medicina Veterinária e Zootecnia
Papain is a proteolytic enzyme removed from the leaves of green papaya and/or latex. This enzyme is widely known as a medicinal fruit used extensively in human medicine for the treatment of wounds of various etiologies.
M.Y.H. Porsani   +5 more
doaj   +1 more source

Follow-up of fluorine pollution effect on grapevine

open access: yesOENO One, 2004
Effects of atmospheric pollution on three local grapevines, Asli, Jerbi and Tounsi, growing in the vicinity of a phosphate fertiliser factory, consist of an exhibition of characteristic necrosis on leaves and fruits.
Ferjani Ben Abdallah   +3 more
doaj   +1 more source

Necrosis and the Serpin Under't [PDF]

open access: yesDevelopmental Cell, 2007
Caspase proteases play essential roles in apoptotic cell death, while other proteases are active in necrotic cell death. In a recent paper in Cell, Luke et al. (2007) present findings demonstrating that a gene believed to be a natural protease inhibitor may have a role in preventing necrosis.
Mary C. Abraham, Shai Shaham
openaire   +3 more sources

Investigation of tumor tissue alteration after experimental chemotherapy [PDF]

open access: yesМорфологія, 2009
The aim of the present work was the study of tumor tissue alteration after new antineoplastic substance administration in comparison with widely investigated 5-fluorouracil.
Grygorieva E. V.
doaj  

Original Articles Preoperative Hematological Parameters for Predicting Ovarian Torsion in Patients with Mature Cystic Teratoma

open access: yesInternational Journal of Women's Health, 2021
Jisun Lee,1 Jinyoung Park,2 Hyun Jung Lee,1 Mi Ju Kim,1 Yoon Hee Lee,3 Gun Oh Chong,3 Dae Gy Hong,3 Taek Hoo Lee1 1Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu ...
Lee J   +7 more
doaj  

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

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