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Statin-Induced Necrotizing Autoimmune Myositis Presenting With Progressive Limb-Girdle Weakness Following Low-Dose Atorvastatin Use. [PDF]
CureusAnnous L, Mahmoud O.
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Cardiac and Respiratory Complications of Necrotizing Autoimmune Myopathy
Mayo Clinic Proceedings, 2020To characterize the cardiorespiratory abnormalities in patients with necrotizing autoimmune myopathy (NAM).Cardiopulmonary features of patients with NAM evaluated in our neuromuscular clinic (January 1, 2004, to September 20, 2018) were reviewed retrospectively with respect to autoantibody status and history of cardiac disease. Clinical characteristics
, James Triplett, Teerin Liewluck
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Statin induced necrotizing autoimmune myopathy
Journal of the Neurological Sciences, 2015Statin induced necrotizing autoimmune myopathy (SINAM) is a recently characterized entity belonging to the spectrum of statin myotoxicity. It is a more severe form, and is usually associated with significant proximal muscle weakness, strikingly elevated creatine kinase levels and persistent symptoms despite statin discontinuation.
Yuebing Li
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Statin-associated necrotizing autoimmune myopathy
Modern Rheumatology, 2013Necrotizing autoimmune myopathy (NAM) is a severe adverse effect of statins. We report a 66-year-old Caucasian female who had progressive proximal muscle weakness after treatment with statins. Results of a muscle biopsy showed necrotizing myopathy with minimal inflammatory cell infiltrate and increased major histocompatibility class I antigen ...
Samuel Shinjo +2 more
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Polymyositis, Dermatomyositis, and Autoimmune Necrotizing Myopathy: Clinical Features
Rheumatic Disease Clinics of North America, 2011Idiopathic inflammatory myopathies are a heterogeneous group of autoimmune disorders predominantly affecting skeletal muscles, resulting in muscle inflammation and weakness. The 3 most common inflammatory myopathies are polymyositis (PM), dermatomyositis (DM), and inclusion body myositis.
Lisa Christopher-Stine, Sabiha Khan
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Role of Intravenous Immunoglobulin in Necrotizing Autoimmune Myopathy
JCR: Journal of Clinical Rheumatology, 2021Background/Objective Immune-mediated necrotizing myopathy (IMNM) is a subtype of myositis that is associated with a refractory phenotype and poorer prognosis. The aim of the study was to provide single large center experience of outcomes of intravenous immunoglobulin (IVIg) for patients with IMNM using longitudinally collected ...
Amanda, Kocoloski +6 more
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Necrotizing autoimmune myopathy
Current Opinion in Rheumatology, 2011Necrotizing autoimmune myopathy (NAM) is a relatively newly recognized subgroup of idiopathic inflammatory myopathies, which despite diverse causes, have the common histopathological features of myocyte necrosis without significant inflammation. Patients present with a subacute severe symmetrical proximal myopathy, associated with a markedly elevated ...
Liang, C., Needham, M.
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Necrotizing autoimmune myopathy
Orvosi Hetilap, 2012Idiopathic inflammatory myopathies are systemic autoimmune diseases characterized by symmetrical proximal muscle weakness. One of them is the subgroup of necrotizing autoimmune myopathy, which has recently been recognized as a separate entity. In addition to the typical symmetrical muscle weakness, it is characterized by very high creatine kinase ...
Levente, Bodoki +6 more
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[Necrotizing autoimmune myopathies].
Revue neurologique, 2014Necrotizing autoimmune myopathies are included in the spectrum of inflammatory myopathies, together with polymyosis, dermatopolymyosis and inclusion body myositis, despite the characteristic feature of marked muscular necrosis without inflammatory infiltrates.
P, Petiot +4 more
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Autoimmune Necrotizing Myopathies: Subtypes and Advances in Treatment
Current Treatment Options in Rheumatology, 2017Purpose of Review Necrotizing autoimmune myopathies (NAM), or immune-mediated necrotizing myopathies (IMNM), are considered as a unique category of autoimmune myopathy given their distinctive histologic, serologic, and clinical features. The goals of this article are to review the subtypes of IMNM and to discuss treatment options that apply to these ...
Jason Liebowitz, Lisa Christopher-Stine
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