Results 91 to 100 of about 85,835,167 (297)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Climate Anxiety and the Subjective Need for Punishment for Perceived Climate Damaging Behaviour
Bioderecho.es“Climate anxiety,” a relatively recent phenomenon, refers to the challenges individuals face when confronting concerns stemming from climate change. People can tackle this anxiety by seeking to change either themselves or their environment. For instance,
Kerstin Wüstner
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Closing the Group or the Market? The Two Sides of Weber’s Concept of Closure and Their Relevance for the Study of Intergroup Inequality [PDF]
, 2013 Cardona A. Closing the Group or the Market? The Two Sides of Weber’s Concept of Closure and Their Relevance for the Study of Intergroup Inequality. SFB 882 Working Paper Series. Vol 15.
Cardona, Andrés
core
A need basis for values: Associations between the need for cognitive closure and value priorities [PDF]
, 2009 Values are viewed as partly based on needs, but little research has been devoted to testing this relationship. The need to attain or avoid cognitive closure may be an important cognitive-motivational factor underlying the endorsement and pursuit of ...
Bardi, Anat +4 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Base Realignment and Closure: Guiding Principles for Peru [PDF]
In this paper, we examine the prospects for base realignment and closure in Peru and develop an initial strategy for the realignment and closure process.
Robert M McNab
core
Individual differences in need for closure and voting
, 2008 Two longitudinal studies investigated the relationship between dispositional need for closure and voting behaviour. It wits hypothesized that need for closure wits linearly related with voting for more conservative Italian parties.
CHIRUMBOLO, Antonio, LEONE, Luigi
core +1 more source
Why do people stigmatize depression? Need for cognitive closure and materialism as risk factors
Current Issues in Personality PsychologyBackground Despite various anti-stigma initiatives, the stigmatization of individuals suffering from depression remains a significant issue. While previous studies have examined the influence of demographic factors on self-stigma related to depression ...
Rosana Stan, Ana Stoianov
doaj +1 more source