Results 111 to 120 of about 81,661,203 (277)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Examining Need for Cognition and Feedback with Team Virtuality

open access: yes, 2007
In response to an increase in global operations and the use of computers in the workplace, there has been an expansion of research on dispersed or virtual groups.
Roybal, Adam, Rusk, Alison
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

Learner characteristics predict performance and confidence in e-learning: an analysis of user behaviour and self-evaluation. [PDF]

open access: yes, 2014
We examined the role of learner characteristics as predictors of four aspects of e-learning performance, including knowledge test performance, learning confidence, learning efficiency, and navigational effectiveness.
Stamov Roßnagel, Christian   +2 more
core  

ADAPTASI BAHASA DAN BUDAYA NEED FOR COGNITION SCALE

open access: yesJurnal Sains Psikologi, 2018
Penelitian ini bertujuan untuk melakukan adaptasi need for cognition scale (NCS) (Cacioppo, dkk., 1984) untuk sampel siswa SMP di Indonesia. NCS dikembangkan untuk mengukur konstruk need for cognition yang didefinisikan sebagai kecenderungan individu ...
Ika Andrini Farida   +2 more
doaj  

Influence of Need for Cognition and Need for Cognitive Closure on Information Behaviour: Qualitative Results

open access: yesProceedings of the Annual Conference of CAIS / Actes du congrès annuel de l'ACSI, 2016
This project studies the influence of two traits, Need for Cognition and Need for Cognitive Closure, on information behaviour. Qualitative analysis of 40 critical incidents collected through semi-structured interviews with undergraduate students demonstrates four distinct profiles: inquisitive enthusiasts, pragmatic enthusiasts, indifferent minimalists
openaire   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

open access: yesFEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara   +3 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy