Results 91 to 100 of about 321,848 (300)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Los Estudios de Opinión y su Influencia en las Preferencias de las Personas The Influence of Opinion Polls on People's Preferences

open access: yesPsykhe, 2007
Este artículo revisa la evidencia existente sobre la influencia que las encuestas tienen en la manifestación de preferencias tanto en términos de asumir una posición (de mayoría -bandwagon- o de minoría -underdog) como de las variables que mediatizan ...
Rodrigo Uribe, Enrique Manzur
doaj  

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

Binge-Watching Dependence: A Function of Sensation Seeking, Need for Cognition, and Flow

open access: yesInternational Journal of Communication, 2022
This study discusses various definitions and features of the binge-watching phenomenon, with a particular focus on psychological traits, sensation seeking (SSK), and need for cognition (NFC).
Hongjin Shim, Yoon Hi Sung
doaj  

The unavoidable need for distributed cognition in teaching literacy

open access: yesSouth African Journal of Childhood Education, 2011
Certain tasks are more likely to be solved by groups than by individuals, even when the individuals are highly skilled at aspects of the task. These are tasks such as filling out income tax forms or performing surgical operations, for which inputs from ...
Catherine Elizabeth Snow
doaj   +1 more source

Examining the Effect of Reverse Worded Items on the Factor Structure of the Need for Cognition Scale

open access: yesPLoS ONE, 2016
Reverse worded (RW) items are often used to reduce or eliminate acquiescence bias, but there is a rising concern about their harmful effects on the covariance structure of the scale.
Xijuan Zhang, Ramsha Noor, V. Savalei
semanticscholar   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Predicting Agricultural Sciences Students’ Media Literacy in a Post-Truth Era

open access: yesJournal of Human Sciences and Extension
As more individuals turn to various forms of online media to seek information, misinformation and skepticism are on the rise when considering news media.
Abigail Durheim   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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