Results 81 to 90 of about 85,211,403 (287)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The intergenerational transmission of need for closure underlies the transmission of authoritarianism and anti-immigrant prejudice [PDF]

, 2013
Previous research has identified need for closure (NFC) as an important motivational cognitive basis of authoritarianism and prejudice. However, to date, the role of NFC in the intergenerational similarity in authoritarianism and prejudice has remained ...
Roets, Arne, Van Hiel, Alain, Dhont, Kristof   +2 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Cognitive Engagement Mediates the Relationship between Positive Life Events and Positive Emotionality

Frontiers in Psychology, 2017
Need for Cognition (NFC) is conceptualized as an individuals’ tendency to engage in and enjoy effortful cognitive activity and, thus, captures one’s cognitive engagement.
Alexander Strobel, Kristin Anacker, Anja Strobel   +2 more
doaj   +1 more source

Differences Teach Us More Than Similarities : The Need for Evolutionary Thinking in Comparative Cognition

A persistent anthropocentric school of thought prevents comparative cognition from truly joining the evolutionary sciences, which often view “cognition” as an alien subject to the study of life.
Reber, Stephan A.,, Lund University., Stephan A. Reber, Reber, Stephan A.   +3 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Striving for accuracy attenuates the positive relationship between cyberbullying bystanders’ dispositional empathy and tendencies to help victims

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace
Empathy is a key predictor of bystanders’ helping behaviors, yet its role in cyberbullying contexts has yielded inconsistent findings. This study investigated whether accuracy motivation, the drive to form correct and well-reasoned judgments, moderates ...
Cheng-Hong Liu, Fa-Chung Chiu, Po-Sheng Huang, Ting-Huan Lin, Chia-Lin Chang   +4 more
doaj   +1 more source

Culture and Cognitive Theory: Toward a Reformulation [PDF]

, 2001
In a provocative and important recent article Anthony Marsella (1998) makes an eloquent plea for the forging of a new metadiscipline of psychology that he labels global-community psychology.
Durrant, Russil, Thakker, Jo
core  

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source