Results 71 to 80 of about 85,211,403 (287)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Tracing Need for Cognition in Digital Learning
Computers in Human BehaviorNeed for Cognition (NFC) reflects individuals’ tendencies to engage in and enjoy effortful cognitive activities and has been linked to positive academic outcomes (e.g., higher academic achievement). However, the extent to which NFC is expressed in actual learning behaviors remains unclear.
Aki Schumacher +5 more
openaire +2 more sources
Cognitive Skills Needed for Social Hierarchies [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2014 Dominance hierarchies are ubiquitous in social species that require social cognition to maintain. Status may be established initially through physical conflict but is maintained by social signals between individuals that depend critically on the relative social status of those interacting.
openaire +2 more sources
PSYNDEX Tests Review für NFC-KIDS - Need for Cognition - Kinderskala
, 2017 This is a PSYNDEX Tests Review of NFC-KIDS - Need for Cognition - Kinderskala. PSYNDEX Tests Reviews are written in German and describe and evaluate psychological and educational tests used in the German-speaking countries.
Schroth, Jennifer
core +1 more source
The Effect of Need for Cognition on Attitude Change
, 2021 The study aims to replicate the results of Luttrell et al. (2017) conceptually. The focus is the interaction effect of need for cognition (NFC) and argument quality (AQ), which was first explored by Cacioppo et al. (1983). According to the original study,
Julia Sutter
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Correlation of Need for Cognition and Modern Racism
, 1993 Survey results from 59 college students indicated that those low in need for cognition evidenced higher racial prejudice than respondents high in need for cognition.
James Waller
core +1 more source