Results 101 to 110 of about 1,013,636 (296)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Striving for accuracy attenuates the positive relationship between cyberbullying bystanders’ dispositional empathy and tendencies to help victims

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace
Empathy is a key predictor of bystanders’ helping behaviors, yet its role in cyberbullying contexts has yielded inconsistent findings. This study investigated whether accuracy motivation, the drive to form correct and well-reasoned judgments, moderates ...
Cheng-Hong Liu, Fa-Chung Chiu, Po-Sheng Huang, Ting-Huan Lin, Chia-Lin Chang   +4 more
doaj   +1 more source

Understanding safety-critical interactions with a home medical device through Distributed Cognition [PDF]

, 2015
As healthcare shifts from the hospital to the home, it is becoming increasingly important to understand how patients interact with home medical devices, to inform the safe and patient-friendly design of these devices.
Blandford, AE, Mayer, A, Rajkomar, A
core  

Commonplaces in risk talk: Face threats and forms of interaction. [PDF]

, 2007
Talk about risk is problematic for interaction; it can involve the speaker or hearer saying things that threaten participants' 'face', the ways they want themselves to be seen by others.
Myers, Greg
core   +1 more source

Influence of Need for Cognition and Need for Cognitive Closure on Information Behaviour: Qualitative Results

Proceedings of the Annual Conference of CAIS / Actes du congrès annuel de l'ACSI, 2016
This project studies the influence of two traits, Need for Cognition and Need for Cognitive Closure, on information behaviour. Qualitative analysis of 40 critical incidents collected through semi-structured interviews with undergraduate students demonstrates four distinct profiles: inquisitive enthusiasts, pragmatic enthusiasts, indifferent minimalists
openaire   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Los Estudios de Opinión y su Influencia en las Preferencias de las Personas The Influence of Opinion Polls on People's Preferences

Psykhe, 2007
Este artículo revisa la evidencia existente sobre la influencia que las encuestas tienen en la manifestación de preferencias tanto en términos de asumir una posición (de mayoría -bandwagon- o de minoría -underdog) como de las variables que mediatizan ...
Rodrigo Uribe, Enrique Manzur
doaj  

Binge-Watching Dependence: A Function of Sensation Seeking, Need for Cognition, and Flow

International Journal of Communication, 2022
This study discusses various definitions and features of the binge-watching phenomenon, with a particular focus on psychological traits, sensation seeking (SSK), and need for cognition (NFC).
Hongjin Shim, Yoon Hi Sung
doaj