Results 91 to 100 of about 20,721 (236)

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Effect of heat-reinforcing needling on expression profile of LncRNAs in synovial tissues of rabbits with cold-syndrome type rheumatoid arthritis

针刺研究
ObjectiveTo observe the effect of heat-reinforcing needling on the expression profile of long non-coding RNA （LncRNA） in the synovial tissue of rabbits with cold-syndrome type rheumatoid arthritis （RA）， so as to explore its mechanisms underlying ...
DU Xiao-zheng, LIU Li-mei, LIU Cui, JING Wei-yao, YUAN Bo, ZHANG Xing-hua, ZHANG Feng-fan, LI Xiang-jun, LIU Qiang, WANG Hai-dong   +9 more
doaj  

Temporal dynamics and spatial variability in the enhancement of canopy leaf area under elevated atmospheric CO₂

, 2007
Increased canopy leaf area (L) may lead to higher forest productivity and alter processes such as species dynamics and ecosystem mass and energy fluxes.
Millar, Bonnie, Oren, Ram, Ellsworth, David S., Finzi, Adrien C., Kim, Hyun-Seok, Johnsen, Kurt H., McCarthy, Heather R.   +6 more
core   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Study on Phenological Characteristics of Abies pindrow Royle in Different Sites of Kashmir Himalayas

Phenology refers to the timing of recurring biological events in a species life cycle and is a crucial aspect of life history for both flora and fauna. Studying phenology plays a vital role in identifying regeneration challenges in plant species.
Mehak, Mubariz, Khan, P.A, Shah, Khursheed A., Mir, Ashfaq A., Jeelani, M.I, Dutt, Vaishnu   +5 more
core   +1 more source

Respostas de aclimatação de Acrostichum danaeifolium Langsd. & Fisch. (Polypodiopsida, Pteridaceae) à radiação ultravioleta B [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biologia de Fungos, Algas e Plantas, Florianópolis, 2015.A destruição da camada de ozônio na estratosfera principalmente pela ...
Fonini, Adriano Moratelli
core  

The meristem-associated endosymbiont Methylorubrum extorquens DSM13060 reprograms development and stress responses of pine seedlings

, 2022
Microbes living in plant tissues—endophytes—are mainly studied in crop plants where they typically colonize the root apoplast. Trees—a large carbon source with a high capacity for photosynthesis—provide a variety of niches for endophytic colonization. We
Kvist, J. (Jouni), Fluch, S. (Silvia), Pohjanen, J. (Johanna), Podolich, O. (Olga), Koskimäki, J. J. (Janne J.), Fester, T. (Thomas), Edesi, J. (Jaanika), Pirttilä, A. M. (Anna Maria), Häggman, H. (Hely), Härtig, C. (Claus)   +9 more
core  

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Morphologically Normal-Appearing Mammary Epithelial Cells Obtained from High-Risk Women Exhibit Methylation Silencing of INK4a/ARF.

, 2007
Purpose: p16(INK4a) has been appreciated as a key regulator of cell cycle progression and senescence. Cultured human mammary epithelial cells that lack p16(INK4a) activity have been shown to exhibit premalignant phenotypes, such as telomeric dysfunction,
Ostrander, J, Yee, L, Seewaldt, VL, Baker, JC, Bean, GR, Case, NR, Broadwater, G, Fabian, CJ, Kimler, BF, Brander, DMU, Tlsty, TD, Paisie, C, Bryson, AD, Reynolds, Paul Andrew, Scott, V, Zalles, CM, Pilie, PD, Ibarra, C, Dietz, E, Gauthier, M, Wilke, LG, Goldenberg, V   +21 more
core   +1 more source