Results 181 to 190 of about 8,424,658 (307)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Correction: Close to the border-Resilience in healthcare in a European border region: Findings of a needs analysis. [PDF]

PLoS One
Loeffler LAK, Lambert SI, Bouché L, Klasen M, Sopka S, Vogt L.   +5 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Needs analysis of leadership education based on the medical leadership competency framework in Korean medical schools. [PDF]

Korean J Med Educ
Im JH, Choi H, Kang WS, Kim EK, Lee DH.
europepmc   +1 more source

Health needs analysis based on the functional assessment of workers seen in primary care. [PDF]

Rev Bras Med Trab, 2021
Silva-E-Dutra FCM, Barcelos JLM, Kososki E, Cavalcanti A.   +3 more
europepmc   +1 more source

Needs Analysis Questionnaire

US-China Education Review B, 2021
null Kaskani Aliki, null M.Ed. EFL Teacher   +1 more
openaire   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Needs Analysis of Supportive Care for Postoperative Wound Rehabilitation in Anal Fistula Patients Based on the Kano Model. [PDF]

J Multidiscip Healthc
Zhou C, He Y, Yang P, Du J, Yang C, Wang X.   +5 more
europepmc   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Stakeholder Perspectives on Telehealth Effectiveness, Facilitators, and Barriers for Wheelchair Service Provision: A Needs Analysis. [PDF]

Int J Telerehabil
Taylor R, Schein R, Morrow C.
europepmc   +1 more source