Results 151 to 160 of about 36,760 (309)

Negation in Early English: Grammatical and Functional Change

open access: yes, 2017
Informed by detailed analysis of data from large-scale diachronic corpora, this book is a comprehensive account of changes to the expression of negation in English. Its methodological approach brings together up-to-date techniques from corpus linguistics
Wallage, Phillip
core  

Health promotion as an opportunity for emancipation - DOI: 10.3395/reciis.v1i2.88en

open access: yesRECIIS, 2007
In the present work the possibilities offered by health promotion, reviewed as a negation of negation and its identity, in contrast with the presently understood model of health/disease, circular and reproductive in nature, are discussed.
Fernando Lefevre   +1 more
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Negation in the history of Low German and Dutch

open access: yes, 2013
This chapter looks at the progress of Jespersen’s cycle in Low German and Dutch, tracing the emergence of a new marker of negation (nicht, niet) replacing earlier preverbal ni/ne/en and the very slow process by which the original marker fell out of use ...
Breitbarth, AnneLW060001413681038020007104590000-0001-8300-8275268F32D2-F0EE-11E1-A9DE-61C894A0A6B4   +3 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Negative constructions in selected Middle English verse texts

open access: yes, 2012
The objective of the present study is to investigate the historical development of negative constructions in ME verse and to provide a descriptive account of it. The central issues analyzed in this thesis are: (1) the usage of the negative adverbs 'ne'
Iyeiri, Yoko
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

A negação sintática em diálogos do alemão e do português do Brasil

open access: yesPandaemonium Germanicum: Revista de Estudos Germanísticos, 2001
Der Aufsatz präsentiert die Ergebnisse einer Untersuchung der syntaktischen Negation in deutschen und brasilianischen Dialogen. Nach einigen Überlegungen über Negation und Sprache wird ihre Okkurrenz in einem Corpus von Dialogen in beiden Sprachen in ...
Selma M. Meireles
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Preverbal negative markers in Buli

open access: yes, 2009
This article deals with some aspects of negation in Buli, a Gur language spoken by the Bulsa people in Northern ...
Schwarz, Anne
core  

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