Results 41 to 50 of about 179,714 (239)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Research on flexible uninterrupted neutral section passing system based on V-clamp multilevel converter

Energy Reports, 2023
This paper proposes a novel flexible uninterrupted neutral section passing system based on four-leg V-clamp multilevel converter (VMC). It can better solve a series of problems such as overvoltage, overcurrent and speed loss caused by the interruptible ...
Jiawei Guo, Kai Li, Trillion Q. Zheng, Chenchen Wang, Xiaojie You   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

An Adaptive Reclosing Scheme for Cross-Line Faults on Double-Circuit Wind Power Outgoing Lines with Shunt Reactors

Energies
Wind turbines are vulnerable to negative sequence current injection, the conventional automatic reclosing scheme for wind power outgoing lines, since we may inject negative sequence components into the system and reclose it without distinguishing the ...
Sen Hu, Chao Xie, Chunya Yin
doaj   +1 more source

Research on the Control Strategy of Star Cascaded SVG underThree-phase Unbalanced Conditions

Kongzhi Yu Xinxi Jishu, 2021
Star cascaded static var compensator (SVG) does not regulate power among phases under the condition of unbalanced voltage. It will cause serious imbalance of three-phase DC voltages, and made device withdraw from operation because of over-voltage or ...
WU Bing, HU Xiaodong, LI Sufen, ZHANG Dinghua, WANG Feng, XU Yong   +5 more
doaj  

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

An Application of a Dual-Module VSG Based on QPR and Virtual Impedance in Three-Phase Unbalanced Power Grids

Energies
As an innovative solution, the virtual synchronous generator (VSG) facilitates the seamless incorporation of renewable energy into power grids. It also exhibits the ability to reconfigure system inertia and deliver damping effects, thereby assuming a ...
Liping Fan, Mingjun Wang
doaj   +1 more source

Dynamic Voltage Support of Converters during Grid Faults in Accordance with National Grid Code Requirements

Energies, 2020
To ensure system stability, national grid codes often require converter-based generators to provide fault-ride-through (FRT) capabilities and dynamic voltage support, according to which they should stay connected and support the voltage during fault ...
Jürgen Marchgraber, Wolfgang Gawlik
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source