Results 71 to 80 of about 8,376,724 (319)

Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology [PDF]

, 2012
Non-negative matrix factorization is a useful tool for reducing the dimension of large datasets. This work considers simultaneous non-negative matrix factorization of multiple sources of data.
Clare M. Lee, Vass J. Keith, D R Haggart, Lee Clare M., Mudaliar, MAV, Higham, Desmond, Vass, D.J., Manikhandan A V Mudaliar, Gino Miele, Mudaliar, Manikhandan A.V., Haggart, D. R., Mudaliar, M.A.V., Higham, Desmond J., Haggart D. R., Crowther, Daniel, D. R. Haggart, Lee, C.M., Lee, Clare M., Mudaliar Manikhandan A. V., J Keith Vass, Higham Desmond J., Wolf, C.R., Higham, D.J., Wolf C. Roland, Miele Gino, Mudaliar, Manikhandan A. V., Miele, Geno, Desmond J Higham, Clare M Lee, C. Roland Wolf, Miele, G., Manikhandan A. V. Mudaliar, C Roland Wolf, Crowther Daniel, Vass, J.K., Miele, Gino, J. Keith Vass, Crowther, D., Crowther, Daniel; id_orcid, Daniel Crowther, Vass, J. Keith, Desmond J. Higham, Haggart, D.R., Wolf, C. Roland, Lee, Clare   +44 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

On Negative Eventualities, Negative Concord, and Negative "Yes/No" Questions

Semantics and Linguistic Theory, 1999
No abstract.
openaire   +2 more sources

Negative suggestibility. [PDF]

Psychological Bulletin, 1905
n ...
openaire   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Hierarchical Fibers with a Negative Poisson’s Ratio for Tougher Composites [PDF]

, 2013
In this paper, a new kind of hierarchical tube with a negative Poisson’s ratio (NPR) is proposed. The first level tube is constructed by rolling up an auxetic hexagonal honeycomb.
Yongtao Sun, Pugno, Nicola M., Y. Sun, Nicola Pugno, Sun, Yongtao, Sun, Y, Pugno, N, Pugno, Nicola   +7 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B

, 2004
BACKGROUND: Available treatments for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B are associated with poor sustained responses. As a result, nucleoside and nucleotide analogues are typically continued indefinitely, a strategy ...
PEGINTERFERON ALFA A. HBEAG NEGATIVE CHRONIC HEPATITIS B. STUDY GROUP, MARCELLIN P, BONINO, FERRUCCIO, LAU GK   +3 more
core  

Raising the tone? The impact of 'positive' and 'negative' campaigning on voting in the 2007 Scottish Parliament election [PDF]

, 2010
Most survey-based research on campaign effects in British elections has focussed on exposure to the campaign. Far less attention has been given to how the campaign is perceived, although American research on the effects of negativecampaigning suggests ...
Pattie, C., Charles Pattie, Denver, D., Robert Johns, Johns, R., Denver, David, Johns, R.A., Denver, D, Mitchell, J, Pattie, C, David Denver, James Mitchell, Pattie, Charles, Johns, Robert, Johns, R, Mitchell, J., Mitchell, James   +16 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source