Results 71 to 80 of about 114,090 (262)

The role of super-spreading events in Mycobacterium tuberculosis transmission: evidence from contact tracing

BMC Infectious Diseases, 2019
Background In current epidemiology of tuberculosis (TB), heterogeneity in infectiousness among TB patients is a challenge, which is not well studied. We aimed to quantify this heterogeneity and the presence of “super-spreading” events that can assist in ...
Yayehirad A. Melsew, Manoj Gambhir, Allen C. Cheng, Emma S. McBryde, Justin T. Denholm, Ee Laine Tay, James M. Trauer   +6 more
doaj   +1 more source

NEGATIVE BINOMIAL APPROXIMATION TO THE BETA BINOMIAL DISTRIBUTION [PDF]

International Journal of Pure and Apllied Mathematics, 2015
This paper determines a bound on the approximation of the beta binomial distribution with parameters n, andby a negative binomial distri- bution with parametersand + + +n . With this bound, it is indicated that the beta binomial distribution can be well approximated by the negative binomial distribution whenis large.
openaire   +1 more source

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

Advanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang, Huadong Xing, Antonella Di Pizio, Qinfei Ke, Xingran Kou, Dachuan Zhang   +5 more
wiley   +1 more source

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

Advanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang, Dayu Hu, Yaqi Dai, Aoyi Geng, Renxiang Guan, Hao Quan, Brett A. McGregor, Zhihan Wang, Nadeem Khan, Hongsheng Zhang, Jinghua Zhang, Mingyang Xia, Xiaoqiong Gu, Di Che, Junguk Hur, Xiaoyu Cui, Kai Guo   +16 more
wiley   +1 more source

Application of the discrete distribution in Bayes analYsis of nature area coverage data

Lietuvos Matematikos Rinkinys, 2012
Classical statistical methods do not always provide desired results for every situation. Therefore, new alternative methods of data analysis are in demand. As the computational power becomes more modern, Bayes statistical methods are increasingly applied
Kęstutis Dučinskas, Eglė Baltmiškytė, Martynas Bučas   +2 more
doaj   +1 more source

Compound Markov negative binomial distribution

Journal of Computational and Applied Mathematics, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

A Real‐Data‐Driven Framework for Evaluating Differential Transcript Usage Methods Across Long‐Read Bulk, Single‐Cell, and Spatial Transcriptomics

Advanced Science, EarlyView.
Grounded in real biological RNA‐seq data, the framework benchmarks ten differential transcript usage (DTU) methods across short‐read bulk, long‐read bulk, long‐read single‐cell, and long‐read spatial transcriptomics. By integrating reference transcript sets with ranked DTU results, the Transcript Set Enrichment Score (TSES) identifies data‐type ...
Chenxing Zhang, Jun Liu, Qi Zhao, Huilong Yin, Angang Yang, Minhua Zheng, Rui Zhang   +6 more
wiley   +1 more source

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

Curvature‐Directed Elongation and Chiral Tilting Drive Asymmetric Tissue Patterning

Advanced Science, EarlyView.
Curvature and cell handedness together break tissue symmetry. On convex and concave surfaces, cells elongate along opposite geometric axes and tilt in a consistent chirality‐driven direction, yielding opposite alignment patterns from the same cells. Reversing intrinsic cell chirality reverses both.
Liyao Xu, Frank Daniel Peters, Haokang Zhang, Madison Stiefbold, Thangam Ramar, Aditya Agarwal, Leo Q. Wan   +6 more
wiley   +1 more source