Results 171 to 180 of about 3,656,879 (280)

Immune checkpoint inhibitor cardiomyotoxicity: a case series of five patients and development of a clinical management algorithm. [PDF]

Intern Med J
Xie SZ, Salem JE, Nagrial A, Menzies A, Thomas L, Ramanathan S, Berglund LJ, Sasson SC, Grey AC, Habib R, Wong M, Carlino MS, Jeffrey B, Mo J, Lin MW.   +14 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A prospective cohort study testing whether oral cavity mucosal tissue variability influences elastic scattering spectroscopy (ESS) measures. [PDF]

Am J Otolaryngol
Sakharkar M, Spokas G, Jalihal P, Berry L, Rodriguez-Diaz E, Bigio IJ, Grillone GA, Krisciunas GP.   +7 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Hepatocellular carcinoma surveillance-is it time to update clinical practice? [PDF]

Hepatobiliary Surg Nutr
Yang J, George J.
europepmc   +1 more source

Negative concord and the minimalist approach

, 2001
openaire   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Multicentre Evaluation of Cepheid Xpert^® Research-Use-Only Panel for Molecular Rapid Detection of Gastrointestinal Pathogens. [PDF]

Microorganisms
Dauwalder O, Kehrmann J, Corvec S, Roelens M, Roussel-Gaillard T, Bixio E, Buer J, Baillemont E, Prodel M, Martinaud C, Cento V.   +10 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Cold hardiness dynamics predict budbreak and associated low-temperature threats in grapevine. [PDF]

New Phytol
Campos-Arguedas F, Kirchhof E, North MG, Londo JP, Bates T, van Leeuwen C, Destrac-Irvine A, Bois B, Kovaleski AP.   +8 more
europepmc   +1 more source