Results 181 to 190 of about 3,656,879 (280)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS. [PDF]

Ann Clin Transl Neurol
Calma AD, Pavey N, Tsuji Y, Ghapar AA, Bos MAJVD, Orden B, Lee G, Mekhael L, Ryder J, Silva CS, McDonald D, Kakar F, Yiannikas C, Kiernan MC, Brown DA, Menon P, Vucic S.   +16 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Association between age at Parkinson's disease onset and divorce: An exploratory analysis from the fox insight cohort. [PDF]

J Parkinsons Dis
Smilowska K, Makos O, Cristales AR, Mehanna R, Fleisher J, Kumar KR, Alcalay RN, Salari M, McConvey V, Zhang B, Savica R, Wamelen DJV.   +11 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Mapping Lymphatic Drainage of the Splenic Flexure: Towards a Patient-Specific Surgical Approach for Splenic Flexure Cancer. [PDF]

ANZ J Surg
Naidu K, Russo R, Ng KS.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Coronavirus disease 2019 (COVID-19) risk and evolving treatment patterns in follicular lymphoma during the pandemic: Insights from the PETReA trial. [PDF]

Br J Haematol
Williams S, Lim YJ, Cooper R, Gamble C, Short H, Arumainathan A, Eyre TA, McKay P, Young M, Bishton M, Gatto S, Macheta M, Zhelyazkova A, Heartin E, Miall F, Warbey V, Opat S, Johnston A, Trotman J, Linton K, Pettitt A.   +20 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Seen and Heard: Gender Identity and Concordance Shapes Caregiver Experiences in Pediatric Orthopaedics. [PDF]

J Pediatr Soc North Am
Haruno LS, Buttrick E, Badrinath R, Sarkar S, Sabatini CS, Brooks JT, Coufal S, Goodbody CM, Horn BD, Lawrence JT, Maguire KJ, Wells L, Williams BA, Shah AS.   +13 more
europepmc   +1 more source