Results 61 to 70 of about 16,232 (241)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
A register approach to negative concord versus negative polarity items in English
LinguisticsNegative concord (NC) is used in many English varieties but usually considered ungrammatical in ‘standard’ contemporary English, where negative polarity items (NPIs) are used.
Rotter Stephanie, Liu Mingya
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Mehrsprachigkeit in Rio Grande do Sul: Zur Negation im Brasilianischen Hunsrückisch
Pandaemonium Germanicum: Revista de Estudos Germanísticos, 2023 Im vorliegenden Artikel wird anhand eines spontansprachlichen Korpus bilingualer Sprecher ein sprachliches Phänomen im brasilianischen Hunsrückischen genauer betrachtet: die Negation.
Esther Rinke, Cristina Flores
doaj
Unnaturalness of Negation – an Old Wives’ Tale Retold
ELOPE, 2006 Negation has a very long history of study. In the realm of logic, negation is seen as a simple operation that turns an affirmative to a negative. This assumption strongly affected the linguistic study of negation, and led to some misconceptions.
Gašper Ilc
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
When the syntactic bootstrap breaks: Some children think any means no
GlossaChildren can use distributional information about where words occur to figure out their meanings. But what happens when two very different words not only have most of their distribution in common, but also compose to form indistinguishable sentential ...
Caitlin Illingworth +4 more
doaj +2 more sources
Negative sensitive items and the discourse-configurational nature of Japanese
Glossa, 2016 We take up three Negative Sensitive Items (NSIs) in Japanese, Wh-MO plain negative indefinites, exceptive XP-sika, and certain minimizing indefinites, such as rokuna N (‘any decent N’).
Hedde Zeijlstra +2 more
doaj +2 more sources
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source