Results 31 to 40 of about 101,829 (247)

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Fast growing research on negative emissions

Environmental Research Letters, 2017
Generating negative emissions by removing carbon dioxide from the atmosphere is a key requirement for limiting global warming to well below 2 °C, or even 1.5 °C, and therefore for achieving the long-term climate goals of the recent Paris Agreement ...
Jan C Minx, William F Lamb, Max W Callaghan, Lutz Bornmann, Sabine Fuss   +4 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Estimated climate impact of replacing agriculture as the primary food production system

Environmental Research Letters, 2021
Global agriculture is the second largest contributor to anthropogenic climate change after the burning of fossil fuels. However the potential to mitigate the agricultural climate change contribution is limited and must account for the imperative to ...
Andrew H MacDougall, Joeri Rogelj, Patrick Withey   +2 more
doaj   +1 more source

Large-Scale Implementation of Bioenergy With Carbon Capture and Storage in the Swedish Pulp and Paper Industry Involving Biomass Supply at the Regional Level

Frontiers in Energy Research, 2021
Bioenergy with carbon capture and storage (BECCS) has been identified as a possible major contributor to efforts to reach ambitious climate targets through the provision of negative emissions–offsetting residual fossil emissions in “hard-to-abate ...
Sebastian Karlsson, Anders Eriksson, Fredrik Normann, Filip Johnsson   +3 more
doaj   +1 more source

Occurrence of Extramedullary Relapses in Pediatric Acute Lymphoblastic Leukemia After Treatment With Blinatumomab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz, Martin Ebinger, Michaela Döring, Markus Mezger, Ursula Holzer, Rupert Handgretinger, Peter Lang, Manon Queudeville   +7 more
wiley   +1 more source

The geopolitics of negative emissions technologies: learning lessons from REDD+ and renewable energy for afforestation, BECCS, and direct air capture

Global Sustainability, 2021
Non-technical summary Negative emissions technologies (NETs) have received increasing interest in recent years as a potential part of a portfolio of measures to address anthropogenic climate change, in particular following the 2015 UN Framework ...
Judith Kreuter, Markus Lederer
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Between Scylla and Charybdis: Delayed mitigation narrows the passage between large-scale CDR and high costs

Environmental Research Letters, 2018
There are major concerns about the sustainability of large-scale deployment of carbon dioxide removal (CDR) technologies. It is therefore an urgent question to what extent CDR will be needed to implement the long term ambition of the Paris Agreement ...
Jessica Strefler, Nico Bauer, Elmar Kriegler, Alexander Popp, Anastasis Giannousakis, Ottmar Edenhofer   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source