Results 41 to 50 of about 131,244 (292)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The geopolitics of negative emissions technologies: learning lessons from REDD+ and renewable energy for afforestation, BECCS, and direct air capture

Global Sustainability, 2021
Non-technical summary Negative emissions technologies (NETs) have received increasing interest in recent years as a potential part of a portfolio of measures to address anthropogenic climate change, in particular following the 2015 UN Framework ...
Judith Kreuter, Markus Lederer
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Between Scylla and Charybdis: Delayed mitigation narrows the passage between large-scale CDR and high costs

Environmental Research Letters, 2018
There are major concerns about the sustainability of large-scale deployment of carbon dioxide removal (CDR) technologies. It is therefore an urgent question to what extent CDR will be needed to implement the long term ambition of the Paris Agreement ...
Jessica Strefler, Nico Bauer, Elmar Kriegler, Alexander Popp, Anastasis Giannousakis, Ottmar Edenhofer   +5 more
doaj   +1 more source

Political, Ethical, and Societal Aspects of Issuing Warnings to Humanity [PDF]

Ecocene: Cappadocia Journal of Environmental Humanities, 2020
The scientific community has a sustained history of issuing warnings to society’s leaders and policy-makers. In such cases, scientists take on the task of alerting those in power to issues they may not notice or not wish to see. A distinctive thing about
Steven Yearley
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Carbon Removal Using Coastal Blue Carbon Ecosystems Is Uncertain and Unreliable, With Questionable Climatic Cost-Effectiveness

Frontiers in Climate, 2022
Mangrove forests, seagrass meadows and tidal saltmarshes are vegetated coastal ecosystems that accumulate and store large quantities of carbon in their sediments.
Phillip Williamson, Jean-Pierre Gattuso, Jean-Pierre Gattuso, Jean-Pierre Gattuso   +3 more
doaj   +1 more source

Radiative forcing from aircraft NOx emissions: Mechanisms and seasonal dependence [PDF]

, 2004
A chemistry-climate model has been applied to study the radiative forcings generated by aircraft NOx emissions through changes in ozone and methane. Four numerical experiments, where an extra pulse of aircraft NOx was emitted into the model atmosphere ...
Stevenson, David S.; id_orcid, Derwent, Richard G., Doherty, Ruth M., Collins, William J., Johnson, Colin E., Sanderson, Michael G.   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source