Results 61 to 70 of about 131,244 (292)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Modulating Electronic States of Cu in Metal‐Organic Frameworks for Emerging Controllable CH4/C2H4 Selectivity in CO2 Electroreduction

Advanced Science
The intensive study of electrochemical CO2 reduction reaction (CO2RR) has resulted in numerous highly selective catalysts, however, most of these still exhibit uncontrollable selectivity.
Mingxu Sun, Jiamin Cheng, Akihiko Anzai, Hirokazu Kobayashi, Miho Yamauchi   +4 more
doaj   +1 more source

Techno-Economic Assessment of Bio-Energy with Carbon Capture and Storage Systems in a Typical Sugarcane Mill in Brazil

Energies, 2019
For significantly reducing greenhouse gas emissions, those from electricity generation should be negative by the end of the century. In this sense, bio-energy with carbon capture and storage (BECCS) technology in sugarcane mills could be crucial.
Sara Restrepo-Valencia, Arnaldo Walter
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

The politics and governance of negative emissions technologies [PDF]

Global Sustainability, 2018
Recent projections to stay within 2°C and especially 1.5°C rely upon both more aggressive emissions cuts and larger scales of “negative emission technologies” (NETs). Yet not only are NETs’ actual development and scalability still uncertain, the technologies would present social and environmental risks of their own.
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Carbon dioxide removal technologies are not born equal

Environmental Research Letters, 2021
Technologies for carbon dioxide removal (CDR) from the atmosphere have been recognized as an important part of limiting warming to well below 2 °C called for in the Paris Agreement.
Jessica Strefler, Nico Bauer, Florian Humpenöder, David Klein, Alexander Popp, Elmar Kriegler   +5 more
doaj   +1 more source

Removing Carbon Now: How can companies and individuals fund negative emissions technologies in a safe and effective way to help solve the climate crisis?

, 2020
Carbon removals are an important part of the solution of the climate crisis, hundreds of gigatons of CO2 will likely need to be removed from the atmosphere this century with the help of a wide range of negative emission technologies.
Höglund, Robert
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