Results 31 to 40 of about 8,630,188 (308)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Production of negatively charged radioactive ion beams
New Journal of Physics, 2017 Beams of short-lived radioactive nuclei are needed for frontier experimental research in nuclear structure, reactions, and astrophysics. Negatively charged radioactive ion beams have unique advantages and allow for the use of a tandem accelerator for ...
Y Liu, D W Stracener, T Stora
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Towards large and powerful radio frequency driven negative ion sources for fusion
New Journal of Physics, 2017 The ITER neutral beam system will be equipped with radio-frequency (RF) negative ion sources, based on the IPP Garching prototype source design. Up to 100 kW at 1 MHz is coupled to the RF driver, out of which the plasma expands into the main source ...
B Heinemann +9 more
doaj +1 more source
Suppression of stray electrons in the negative ion accelerator of CRAFT NNBI test facility
Nuclear Engineering and Technology, 2023 Comprehensive Research Facility for Fusion Technology (CRAFT) is an integration of different demonstrating or testing facilities, which aim to develop the critical technology or composition system towards the fusion reactor.
Yuwen Yang +5 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
A review of negative ion sources [PDF]
Revue de Physique Appliquée, 1977 A brief review of the present status of negative ion sources and their compatability with tandem accelerators will be presented. Recent developments of the caesium beam sputter source will be discussed in some detail including topics such as, the optimum shape of the sputter cone, the use of gases to increase either the elemental negative ion current ...
openaire +2 more sources
Extraction and low energy transport of negative ions [PDF]
, 2005 High perveance negative ion beams with low emittance are essential for several next generation particle accelerators (i. g. spallation sources like ESS [1] and SNS [2]).
Lakatos, Andreas +3 more
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source