Results 51 to 60 of about 333,485 (307)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

High-Energy Acceleration of an Intense Negative Ion Beam [PDF]

, 1995
A high-current H^- ion beam has been accelerated with the two-stage acceleration. A large negative hydrogen ion source with an external magnetic filter produces more than 10 A of the H^- ions from the grid area of 25 cm x 50 cm with the arc efficiency ...
Tanaka, M., Ando, A., Oka, Y., Kaneko, O., Kawamoto, T., Tsumori, K., Kuroda, T.", Asano, E., "Takeiri, Y., Akiyama, R.   +9 more
core  

Analysis and optimization of cesium dynamics for the HUST negative ion source

Nuclear Engineering and Technology
The high-density beam in the NBI negative ion source relies on surface production on the converter with low work function, which is facilitated by cesium injection.
Feng Xue, Chen Zuo, Dong Li, Dezhi Chen
doaj   +1 more source

Theoretical calculation of cesium deposition and co-deposition with electronegative elements on the plasma grid in negative ion sources

Nuclear Materials and Energy, 2023
We studied the work function of cesium deposition and co-deposition with the electronegative element on the plasma grid (PG) using the first-principles calculations.
Heng Li, Xin Zhang, Yuhong Xu, Guangjiu Lei, Katsuyoshi Tsumori, Mitsutaka Isobe, Akihiro Shimizu, Zilin Cui, Yiqin Zhu, Jun Hu, Yuxiang Ni, Shaofei Geng, Haifeng Liu, Xianqu Wang, Jie Huang, Hai Liu, Jun Cheng, Changjian Tang, CFQS team   +18 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Experimental and simulation study on the backstreaming positive ions on the quarter-size negative ion source for CRAFT NNBI test facility

Nuclear Engineering and Technology
As an effective methods of plasma heating, neutral beam injection (NBI) systems based on negative hydrogen ion sources will be utilized in future magnetic-confinement nuclear fusion experiments.
Yongjian Xu, Yuwen Yang, Jianglong Wei, Ling Yu, Wen Deng, Rixin Wang, Yuming Gu, Chundong Hu, Yahong Xie   +8 more
doaj   +1 more source

Negative ion research at the Culham Centre for Fusion Energy (CCFE)

New Journal of Physics, 2016
A summary of negative ion development work being presently undertaken at the Culham Centre for Fusion Energy is given. The small negative ion facility has an RF driven volume ion source with beam extraction at energies up to 30 keV. The extracted beam of
R McAdams, A J T Holmes, D B King, E Surrey, I Turner, J Zacks   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Extraction and low energy transport of negative ions [PDF]

, 2005
High perveance negative ion beams with low emittance are essential for several next generation particle accelerators (i. g. spallation sources like ESS [1] and SNS [2]).
Lakatos, Andreas, Klein, Horst, Pozimski, Jürgen, Jakob, Ansgar   +3 more
core  

Progress of CRAFT negative ion source neutral beam injection test facility

Nuclear Fusion
The Comprehensive Research Facility for Fusion Technology (CRAFT) is a national large research infrastructure in China. CRAFT aims to develop the key technologies for future fusion reactor and the negative ion source neutral beam injection (NNBI) is one ...
Jianglong Wei, Wei Liu, Yongjian Xu, Yuming Gu, Yahong Xie, Na Wang, Bo Liu, Dmitrii Stepanov, Shengmin Pan, Zhigang Zhu, Bin Guo, Xiancai Meng, Xufeng Peng, Hao Wu, Liang Zhang, Chundong Hu, Lizhen Liang, CRAFT NNBI Team   +17 more
doaj   +1 more source