Results 51 to 60 of about 8,630,188 (308)

ITER-relevant 600 s steady-state extraction of negative hydrogen ions at the test facility ELISE

Nuclear Fusion
The neutral beam heating system for the future international fusion experiment ITER will be based on radio-frequency driven ion sources delivering a large (≈1 × 2 m ^2 ) and homogeneous negative hydrogen or deuterium ion beam of several ten Amperes for ...
D. Wünderlich, R. Riedl, M. Fröschle, A. Heiler, A. Navarro, D. Yordanov, A. Döring, U. Fantz   +7 more
doaj   +1 more source

Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization (HePI) mass spectrometry

Journal of Pharmaceutical Analysis, 2014
A simple modification converts an electrospray ion source to an ambient-pressure helium plasma ionization source without the need of additional expensive hardware.
Athula B. Attygalle, Freneil B. Jariwala, Julius Pavlov, Zhihua Yang, Jason A. Mahr, Mabel Oviedo   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Numerical Simulations and the Design of Magnetic Field-Enhanced Electron Impact Ion Source with Hollow Cylinder Structure

Journal of Analytical Methods in Chemistry, 2020
An electron impact ion source-adopted magnetic field-enhanced technology has been designed for enhancing the electron intensity and the ionization efficiency.
Guochen Qi, Di Tian, Guolun Gao, Guangda Liu, Chunling Qiu, Tao Long   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Development of versatile multiaperture negative ion sources [PDF]

AIP Conference Proceedings, 2015
Enhancement of negative ion sources for production of large ion beams is a very active research field nowadays, driven from demand of plasma heating in nuclear fusion devices and accelerator applications. As a versatile test bench, the ion source NIO1 (Negative Ion Optimization 1) is being commissioned by Consorzio RFX and INFN.
Cavenago M, Serianni G, Antoni V, Bigi M, De Muri M, Pasqualotto R, Recchia M, Veltri P, Agostinetti P, Barbisan M, Baseggio L, Cervaro V, Cazzador M, Degli Agostini F, Franchin L, Kulevoy T, Laterza B, Mimo A, Minarello A, Petrenko S, Ravarotto D, Rossetto F, Sattin M, Zaniol B, Zucchetti S   +24 more
openaire   +3 more sources

Conceptional design of photoneutralization test system for negative ion-based neutral beam injection

Nuclear Engineering and Technology
Neutral beam injection is one of the effective heating methods in the field of magnetic confinement fusion, and neutralization is the most crucial link in the case of negative ions.
Hui-hui Hong, Li-zhen Liang, Yuan-lai Xie, Qian-xu Wang, Zhuo Pan, Yao Jiang   +5 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Helicon wave-generated plasmas for negative ion beams for fusion

EPJ Web of Conferences, 2017
In the next generation of fusion reactors, such as DEMO, neutral beam injectors (NBIs) of high energy (0.8-1 MeV) deuterium atoms with high wall-plug efficiency (>50%) will be required to reach burning plasma conditions and to provide a significant ...
Furno Ivo, Agnello Riccardo, Fantz U., Howling Alan, Jacquier Remy, Marini Claudio, Plyushchev Gennady, Guittienne Philippe, Simonin Alain   +8 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source