Results 61 to 70 of about 333,485 (307)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Simulation, design and tests of a diagnostic calorimeter for the spider experiment [PDF]

, 2013
One of the most critical issues for fusion reactors, to be studied in ITER (the prototype that has to prove the feasibility of production of electric energy by fusion), is the generation of sufficient energy to the sustainment of fusion reactions as well
De Muri, Michela
core  

3D modelling of negative ion extraction from a negative ion source [PDF]

, 2010
The development of a suitable negative ion source constitutes a crucial step in the construction of the neutral beam injector of ITER. To fulfil the ITER requirements in terms of heating and current drive, the negative ion source should deliver 40 A of D−
T. Minea, S. Mochalskyy, A.F. Lifschitz
core   +1 more source

ITER-relevant 600 s steady-state extraction of negative hydrogen ions at the test facility ELISE

Nuclear Fusion
The neutral beam heating system for the future international fusion experiment ITER will be based on radio-frequency driven ion sources delivering a large (≈1 × 2 m ^2 ) and homogeneous negative hydrogen or deuterium ion beam of several ten Amperes for ...
D. Wünderlich, R. Riedl, M. Fröschle, A. Heiler, A. Navarro, D. Yordanov, A. Döring, U. Fantz   +7 more
doaj   +1 more source

Helicon wave-generated plasmas for negative ion beams for fusion

EPJ Web of Conferences, 2017
In the next generation of fusion reactors, such as DEMO, neutral beam injectors (NBIs) of high energy (0.8-1 MeV) deuterium atoms with high wall-plug efficiency (>50%) will be required to reach burning plasma conditions and to provide a significant ...
Furno Ivo, Agnello Riccardo, Fantz U., Howling Alan, Jacquier Remy, Marini Claudio, Plyushchev Gennady, Guittienne Philippe, Simonin Alain   +8 more
doaj   +1 more source

Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization (HePI) mass spectrometry

Journal of Pharmaceutical Analysis, 2014
A simple modification converts an electrospray ion source to an ambient-pressure helium plasma ionization source without the need of additional expensive hardware.
Athula B. Attygalle, Freneil B. Jariwala, Julius Pavlov, Zhihua Yang, Jason A. Mahr, Mabel Oviedo   +5 more
doaj   +1 more source

Numerical Simulations and the Design of Magnetic Field-Enhanced Electron Impact Ion Source with Hollow Cylinder Structure

Journal of Analytical Methods in Chemistry, 2020
An electron impact ion source-adopted magnetic field-enhanced technology has been designed for enhancing the electron intensity and the ionization efficiency.
Guochen Qi, Di Tian, Guolun Gao, Guangda Liu, Chunling Qiu, Tao Long   +5 more
doaj   +1 more source

Effect of Coulomb collision on the negative ion extraction mechanism in negative ion sources

Review of Scientific Instruments, 2015
To improve the H− ion beam optics, it is necessary to understand the energy relaxation process of surface produced H− ions in the extraction region of Cs seeded H− ion sources. Coulomb collisions of charged particles have been introduced to the 2D3V-PIC (two dimension in real space and three dimension in velocity space particle-in-cell) model for the H−
Goto I, Miyamoto K, Nishioka S, Mattei S, Lettry J, Abe S, Hatayama A   +6 more
openaire   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source